2019
DOI: 10.4235/agmr.19.0012
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Systemic and Local Phenotypes of Barium Chloride Induced Skeletal Muscle Injury in Mice

Abstract: Skeletal muscle regeneration in mice has traditionally been studied using local freeze burn or snake venom injection models. More recently, a barium chloride (BaCl 2 )-induced muscle injury model has been established and is gaining popularity due to the relatively simple procedure and accessibility to required reagents. Here we sought to characterize the local and systemic effects of BaCl 2 -induced muscle injury. For this study, a 1.2% BaCl 2 … Show more

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Cited by 15 publications
(11 citation statements)
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“…We established the mouse muscle damage model after intramuscularly injecting the mouse gastrocnemius (GAS) muscle with 1.2% barium chloride. Similar to previous findings, 32,33 the hematoxylin-eosin (HE) staining results presented the same damage repair process. We observed muscle lysis and abundant immune cells accumulation at Day 3 (D3) after muscle damage, new myotube formation with centralized nuclei occurring at D5, and immune cells clearance at D7, and at D9, the appearance of muscle bundles was like that of the control group (Figure 1A).…”
Section: Expression Pattern Of Mir-222-3p In Muscle Injury Repair Modelsupporting
confidence: 88%
“…We established the mouse muscle damage model after intramuscularly injecting the mouse gastrocnemius (GAS) muscle with 1.2% barium chloride. Similar to previous findings, 32,33 the hematoxylin-eosin (HE) staining results presented the same damage repair process. We observed muscle lysis and abundant immune cells accumulation at Day 3 (D3) after muscle damage, new myotube formation with centralized nuclei occurring at D5, and immune cells clearance at D7, and at D9, the appearance of muscle bundles was like that of the control group (Figure 1A).…”
Section: Expression Pattern Of Mir-222-3p In Muscle Injury Repair Modelsupporting
confidence: 88%
“…On one hand, hemorrhagic edema persistent at day 3 and gradually subsided during the regeneration process. One the other hand, hemorrhagic in ammation with mononuclear in ltration peaked at day 3 and mostly cleared at day 7 [23,24]. In this study, the crosssectional area and mean diameter of new muscle bers, the number of central nuclear muscle bers, and the wet-weight ratio of tibialis anterior muscle in the Sal group were signi cantly higher than those in the untreated group, indicating that Sal treatment could promote skeletal muscle regeneration.…”
Section: Discussionmentioning
confidence: 45%
“…1A), mouse in the experimental group was injected with BaCl 2 in tibialis anterior muscle (TA) for once, then each mouse in treatment group was intraperitoneally injected with 0.4 mg Sal per day. Signi cant in ammatory in ltration and rhabdomyolysis were observed on the third day after BaCl 2 injury [23,24]. The integrity of TA muscle bers in Sal treated group was signi cantly better than that in control group (Fig.…”
Section: Effects Of Sal On Skeletal Muscle After Bacl 2 Injurymentioning
confidence: 89%
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“…The mouse TA muscle was injured as described previously [51]. Briefly, after the mice were anesthetized with an anesthesia machine, 75 µL of sterile 1.2% BaCl 2 solution was injected into the center of the TA muscle at a fixed point, and the samples were collected at the various time points for analysis.…”
Section: Tibialis Anterior Muscle Injurymentioning
confidence: 99%