Systemic and ocular determinants of mean ocular perfusion pressure in a population-based sample

Çakmak, Ayşe; Atalay, Eray; Irgat, Saadet Gültekin; Köktaş, Zülfiye; Yıldırım, Nilgün

doi:10.1007/s10384-020-00728-1

Cited by 5 publications

(5 citation statements)

References 34 publications

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“…Cakmak et al found that MOPP increased significantly with BMI in healthy adults ≥ 40 years of age. 25 Rajalakshmi et al also found that the MOPP was higher in both men and women in the obese group than in the non-obese group (18 to 19-year-old healthy young adults). 41 A growing body of evidence demonstrated that persons with higher BMI were less myopic.…”

Section: Discussionmentioning

confidence: 91%

“…MOPP was calculated as 2/3 × (DBP + 1/3[SBP – DBP]) - IOP. 25 Ocular biometric parameters were measured with IOL Master (Carl Zeiss, Meditec AG Jena, Germany) and averaged with five measurements. Cycloplegia was performed with 2 drops of 1% cyclopentolate (Alcon) and one drop of tropicamide (Mydrin P; Santen, Osaka, Japan) at 5-minute intervals.…”

Section: Methodsmentioning

confidence: 99%

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Ocular Perfusion Pressure in 7- and 12-Year-Old Chinese Children: The Anyang Childhood Eye Study

Bai

Kang

et al. 2022

Trans. Vis. Sci. Tech.

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Purpose The purpose of this study was to report the distribution of mean ocular perfusion pressure (MOPP) and its associated factors in Chinese children. Methods We enrolled 3048 grade 1 students and 2258 grade 7 students of the Anyang Childhood Eye Study in central China. Systolic and diastolic blood pressure (SBP and DBP) were recorded with a digital automatic sphygmomanometer. Intraocular pressure (IOP) was assessed by a non-contact tonometer. MOPP was calculated as 2/3 × (DBP + 1/3[SBP – DBP]) - IOP. Risk factors for myopia were obtained through a questionnaire survey. Results The MOPP was 33.83 ± 6.37 mm Hg (mean ± SD) in grade 1, which was lower than 36.99 ± 6.80 mm Hg in grade 7 ( P < 0.001). Compared with myopic eyes, non-myopic eyes had higher MOPP in grade 7 (37.72 ± 6.72 mm Hg versus 36.58 ± 6.57 mm Hg, P < 0.001) and in grade 1 (33.88 ± 6.29 mm Hg versus 33.12 ± 7.03 mm Hg, P = 0.12). Multivariable analysis showed that higher MOPP was associated with less myopia ( P < 0.001), higher body mass index (BMI; P < 0.001), thinner central corneal thickness ( P < 0.001), less time on near work ( P < 0.001), and more time on sleeping ( P = 0.04). Conclusions MOPP was higher in children of older age, with higher BMI, less time on near work, and more time on sleeping, and was higher in eyes with less myopia. Translational Relevance We found that MOPP might be an indicator for the detection of myopia development.

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Section: Discussionmentioning

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Ocular Perfusion Pressure in 7- and 12-Year-Old Chinese Children: The Anyang Childhood Eye Study

Bai

Kang

et al. 2022

Trans. Vis. Sci. Tech.

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“…The risk of developing glaucoma may increase in patients with migraine (28) . In a study, it was found that migraine and high IOP increase the risk of low mean ocular perfusion pressure, and this may have a causal relationship with impaired ONH blood flow (29) . In another study, lamina cribrosa and RNFL thicknesses were lower in patients with migraine, and disease duration was significantly correlated with RNFL thickness (30) .…”

Section: Discussionmentioning

confidence: 99%

Arterial hemodynamics and its correlation with retinal microarchitecture in pseudoexfoliation glaucoma

Kocatürk¹,

Abdullayev²,

Bekmez³

et al. 2023

ABO

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“…ONH blood flow is assumed to be directly related to the ocular perfusion pressure (OPP), defined as the difference between the mean systemic arterial blood pressure and intraocular pressure (IOP) [22]. By definition, both systemic hypertension and IOP reduction may cause an increased OPP, i.e., an ONH blood-flow enhancement; on the other hand, systemic hypotension or ocular hypertension could induce ONH blood-supply impairment [23].…”

Section: The Optic Nerve Vascularizationmentioning

confidence: 99%

Non-Arteritic Anterior Ischemic Optic Neuropathy (NA-AION): A Comprehensive Overview

Salvetat,

Pellegrini,

Spadea

et al. 2023

Vision

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Non-arteritic anterior ischemic optic neuropathy (NA-AION) represents one of the most important causes of blindness or severely impaired vision in middle-aged and elderly people. Unilateral optic disc edema and abrupt, painless vision loss are its defining features. It is commonly assumed that NA-AION is caused by an ischemic infarction of the optic nerve head, and, although the exact pathogenesis is still unknown, several risk factors and comorbidities associated with its development have been found. NA-AION occurs generally in patients older than 50 years who have small optic discs and vasculopathy risk factors. Even though numerous treatment options have been proposed, no available effective medical or surgical therapy or prophylactic measure for NA-AION currently exists. The purpose of present-day therapeutic strategies is therefore to identify and possibly control any underlying modifiable risk factors, aiming to prevent the development of new NA-AION episodes in the affected and fellow eye. A thorough assessment of NAION, including its history, epidemiology, etiology, pathophysiology, risk factors, associated comorbidities, clinical findings, diagnostic tests, treatment choices, prognosis, and future research, is the goal of this work.

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Systemic and ocular determinants of mean ocular perfusion pressure in a population-based sample

Cited by 5 publications

References 34 publications

Ocular Perfusion Pressure in 7- and 12-Year-Old Chinese Children: The Anyang Childhood Eye Study

Ocular Perfusion Pressure in 7- and 12-Year-Old Chinese Children: The Anyang Childhood Eye Study

Arterial hemodynamics and its correlation with retinal microarchitecture in pseudoexfoliation glaucoma

Non-Arteritic Anterior Ischemic Optic Neuropathy (NA-AION): A Comprehensive Overview

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