Systemic and Peritoneal Inflammatory Response After Laparoscopic or Conventional Colon Resection in Cancer Patients

Abstract

The systemic proinflammatory concentrations after both surgical approaches represent only a small fragment of what is generated in the peritoneal drain fluid. Even if the immediate levels of proinflammatory cytokines in the serum are significantly lower in the laparoscopic group, the same cytokines locally produced showed no differences, which suggests that the two intra-abdominal approaches are equally traumatic. No differences in cellular response were observed between the groups.

Systemic and Peritoneal Angiogenic Response After Laparoscopic or Conventional Colon Resection in Cancer Patients: A Prospective, Randomized Trial

“…11,12 In more extended laparoscopic procedures such as colon resection for cancer, these advantages are less apparent. 13 Long-term results of a randomized study by Lacy et al have shown significantly longer survival of Stage III colon cancer patients who underwent laparoscopic surgery than patients who received the conventional approach. 14 We investigated the peritoneal and systemic immune response following laparoscopic and conventional surgical approaches in patients with colorectal carcinoma.…”

“…These findings suggest that the surgical wound creates a separate compartment from the systemic circulation in terms of inflammatory response. 13 We studied two important regulators of angiogenesis at a systemic and a local level after surgery. The data showed increased systemic VEGF levels postoperatively after both conventional and laparoscopic surgery, and significant differences were not seen between both approaches.…”

Effect of bisacodyl on postoperative bowel motility in elective colorectal surgery: a prospective, randomized trial

“…Autonomic dysfunction with increased influence of the sympathetic system resulting in inhibition of gut motility, inflammatory response due to surgical trauma, and administration of opioid drugs are important causes of postoperative gastrointestinal dysfunction [3,38]. Gentle surgical technique and the use of minimal invasive techniques result in lower systemic cytokine levels reflecting a lower inflammatory reaction [39]. Additionally, laparoscopic surgery reduces postoperative pain, thus reducing autonomic sympathetic activity.…”

Changes in levels of C-reactive protein in open appendectomy compared to laparoscopic appendectomy

“…Wu et al studied cases that underwent colonic resection by laparoscopy versus open surgery [16]. Serum CRP level was significantly higher than baseline values in both methods.…”

“…Serum CRP level was significantly higher than baseline values in both methods. There was no significant difference between the two methods [16]. Luo et al studied 26 cases that underwent cholecystectomy.…”