Systemic and Regional Haemodynamics in Experimental Renal Hypertension in Conscious Rabbits

Boom, M. van de; Saxena, Pramod R.

doi:10.1111/j.1440-1681.1980.tb00121.x

Cited by 15 publications

(4 citation statements)

References 27 publications

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“…Our data also represent the first evidence that substantial TAs remodeling occurs in the liver, intestine, and bronchi, which are not considered typical targets in hypertension[5],[51]. TRR correlated significantly with data obtained by physiological measures: in the Goldblatt model increased RVR has been shown in every organ, and is most pronounced in kidneys[84],[85],[86],[87]. In normal rats TC correlated with the regional BFR ( Fig 7 ).…”

Section: Discussionsupporting

confidence: 60%

“…In normal rats TC correlated with the regional BFR ( Fig 7 ). However, it was difficult to compare our results with pathophysiological studies because the renal BFR in hypertensive animals has been shown as decreased, increased, or stable as well[84],[88],[89]. Evidently, hemodynamic correlations of TRR, TC and TMV need further investigation.…”

Section: Discussionmentioning

confidence: 91%

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A novel method for comparison of arterial remodeling in hypertension: Quantification of arterial trees and recognition of remodeling patterns on histological sections

et al. 2019

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Remodeling of spatially heterogeneous arterial trees is routinely quantified on tissue sections by averaging linear dimensions, with lack of comparison between different organs and models. The impact of experimental models or hypertension treatment modalities on organ-specific vascular remodeling remains undefined. A wide variety of arterial remodeling types has been demonstrated for hypertensive models, which include differences across organs. The purpose of this study was to reassess methods for measurement of arterial remodeling and to establish a morphometric algorithm for standard and comparable quantification of vascular remodeling in hypertension in different vascular beds. We performed a novel and comprehensive morphometric analysis of terminal arteries in the brain, heart, lung, liver, kidney, spleen, stomach, intestine, skin, skeletal muscle, and adrenal glands of control and Goldblatt hypertensive rats on routinely processed tissue sections. Mean dimensions were highly variable but grouping them into sequential 5 μm intervals permitted creation of reliable linear regression equations and complex profiles. Averaged arterial dimensions demonstrated seven remodeling patterns that were distinct from conventional inward-outward and hypertrophic-eutrophic definitions. Numerical modeling predicted at least nineteen variants of arterial spatial conformations. Recognition of remodeling variants was not possible using averaged dimensions, their ratios, or the remodeling and growth indices. To distinguish remodeling patterns, a three-dimensional modeling was established and tested. The proposed algorithm permits quantitative analysis of arterial remodeling in different organs and may be applicable for comparative studies between animal hypertensive models and human hypertension. Arterial wall tapering is the most important factor to consider in arterial morphometry, while perfusion fixation with vessel relaxation is not necessary. Terminal arteries in organs undergo the same remodeling pattern in Goldblatt rats, except for organs with hemodynamics affected by the arterial clip. The existing remodeling nomenclature should be replaced by a numerical classification applicable to any type of arterial remodeling.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 91%

A novel method for comparison of arterial remodeling in hypertension: Quantification of arterial trees and recognition of remodeling patterns on histological sections

et al. 2019

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“…Recent studies in our laboratory have shown t h a t hypertension induced by unil ateral cellophane wrapping of one kidney with contra1 ateral nephrectomy in rabbits was characterized by a rather uniform increase in regional vascular resistances except for some splanchnic organs ( 4 ) . The enormous increase in t o t a l peripheral resistance after unilateral cellophane wrapping was accompanied by a decrease i n heart rate and stroke volume, resulting in a large reduction ( > 35%) in cardiac o u t p u t (4,15).…”

Section: Introductionmentioning

confidence: 97%

Systemic and Regional Hemodynamic Characteristics of Bilateral Cellophane Perinephritis Hypertension in Conscious Rabbits

Bolt

Saxena

1983

Clinical and Experimental Hypertension. Part A: Theory and Prac

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Using the radioactive microsphere technique, systemic and regional hemodynamic variables were measured in normotensive rabbits and in rabbits with bilateral cellophane perinephritis hypertension. An average decrease in cardiac output of 18 percent was measured in the hypertensive rabbits as a result of a reduction in stroke volume; heart rate remained unchanged. Thus, in the established phase, hypertension was maintained by the elevated total peripheral resistance. A redistribution of cardiac output was observed in the hypertensive rabbits; a significantly higher fraction was received by the brain, small intestine and heart. The weight normalized blood flow to the kidneys, spleen, skeletal muscles, bones and fat was significantly decreased while an increase in vascular resistance was observed in the hypertensive rabbits in all the organs investigated. A negative correlation existed between the weight of the left ventricle and the blood flow to the left ventricle in hypertensive rabbits, suggesting inadequate coronary perfusion as myocardial hypertrophy becomes more pronounced.

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“…1976). Arterial resistance is increased approximately two-fold rather uniformly in most vascular beds, apart from parts of the splanchnic circulation and fat, where there is little or no change (Boom & Saxena 1980). Chronic inhibition of angiotensin converting enzyme attenuates perinephritis hypertension in rabbits by approximately 50%.…”

Section: Introductionmentioning

confidence: 99%

Noradrenaline Sensitivity and Calcium Fluxes in Arteries From Rabbits With Perinephritis Hypertension

Hall

Wadsworth

Kane

et al. 1990

Clin Exp Pharma Physio

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1. Contractions of isolated vascular and cardiac preparations taken from rabbits with perinephritis (one kidney, one wrapped) hypertension were compared with those of preparations from control operated animals. 2. Significantly increased sensitivity to noradrenaline, which acts on alpha 1-adrenoceptors, was found in mesenteric arterial rings but not in aortic rings. The degree of hypersensitivity was the same in the presence and absence of cocaine, suggesting that there is no increase in uptake of noradrenaline into adrenergic nerves in this model of hypertension. In contrast to these agonist-induced contractions, no increased sensitivity was found to potassium chloride, suggesting that hypersensitivity is specific for receptor mediated rather than membrane potential mediated effects. 3. No hypersensitivity to noradrenaline was found in the isolated left or right atria, which suggests that the hypertension is associated with changes in excitation-contraction coupling in blood vessels but not in cardiac muscle. 4. Hypertension increased basal 45Ca uptake in the mesenteric artery but not in the aorta. However, there was no significant difference between preparations from normotensive and hypertensive rabbits in 45Ca uptake or efflux stimulated by noradrenaline or KCl. 5. Increased basal 45Ca uptake could contribute to the increased sensitivity to noradrenaline found in the mesenteric artery in rabbit perinephritis hypertension.

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Systemic and Regional Haemodynamics in Experimental Renal Hypertension in Conscious Rabbits

Cited by 15 publications

References 27 publications

A novel method for comparison of arterial remodeling in hypertension: Quantification of arterial trees and recognition of remodeling patterns on histological sections

A novel method for comparison of arterial remodeling in hypertension: Quantification of arterial trees and recognition of remodeling patterns on histological sections

Systemic and Regional Hemodynamic Characteristics of Bilateral Cellophane Perinephritis Hypertension in Conscious Rabbits

Noradrenaline Sensitivity and Calcium Fluxes in Arteries From Rabbits With Perinephritis Hypertension

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