Systemic and renal hemodynamic effects of intra-arterial radiocontrast

Calzavacca, Paolo; Ishikawa, Ken; Bailey, Michael; May, Clive N.; Bellomo, Rinaldo

doi:10.1186/s40635-014-0032-z

Cited by 6 publications

(4 citation statements)

References 33 publications

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“…Subsequently, different studies were conducted to evaluate the effects of CM exposure in human kidneys, indicating that CM administration is associated with increased urinary FENa [ 152 , 153 ]. These findings were also corroborated in animal models [ 154 , 155 ].…”

Section: Novel Biomarkers: the Necessity For A Precise Ci-aki Diagnosissupporting

confidence: 63%

Biomarkers in Contrast-Induced Acute Kidney Injury: Towards A New Perspective

González-Nicolás,

González-Guerrero,

Goicoechea

et al. 2024

IJMS

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Contrast-Induced Acute Kidney Injury (CI-AKI) remains a frequent iatrogenic condition since radiological procedures using intra-vascular iodinated contrast media (CM) are being widely administered for diagnostic and therapeutic purposes. Despite the improvement of the medical healthcare system worldwide, CI-AKI is still associated with direct short-term and indirect long-term outcomes including increased morbidity and mortality, especially in patients with underlying pre-existing renal function impairment, cardiovascular disease, or diabetes that could rapidly progress into Chronic Kidney Disease. Although the RIFLE (Risk, Injury, Failure, Loss, End-Stage Kidney Disease), AKIN (Acute Kidney Injury Network), and KDIGO (Kidney Disease Improving Global Outcomes) clinical criteria and recommendation guidelines are based on traditional “gold standard” biomarkers known as serum creatinine, glomerular filtration rate, and urinary output, new reliable serum and urinary biomarkers are still needed for an effective unified diagnostic strategy for AKI. Starting from previous and recent publications on the benefits and limitations of validated biomarkers responding to kidney injury, glomerular filtration, and inflammation among others, this review unravels the role of new emerging biomarkers used alone or in combination as reliable tools for early diagnosis and prognosis of CI-AKI, taking into account patients and procedures-risk factors towards a new clinical perspective.

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Section: Novel Biomarkers: the Necessity For A Precise Ci-aki Diagnosissupporting

confidence: 63%

Biomarkers in Contrast-Induced Acute Kidney Injury: Towards A New Perspective

González-Nicolás,

González-Guerrero,

Goicoechea

et al. 2024

IJMS

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show abstract

“…Subsequently, different studies were conducted to evaluate the effects of CM exposure in human kidneys, indicating that CM administration is associated with increased urinary FENa [120,121]. These findings were also corroborated in animal models [122,123].…”

Section: Fractional Excretion Of Sodium (Fena)mentioning

confidence: 83%

Biomarkers in Contrast-Induced Acute Kidney Injury: Towards a new perspective.

González-Nicolás,

González-Guerrero,

Goicoechea

et al. 2024

Preprint

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Contrast-Induced Acute Kidney Injury (CI-AKI) remains a frequent iatrogenic condition since radiological procedures using intra-vascular iodinated contrast media (CM) are being widely administered for diagnostic and therapeutic purposes. Despite the improvement of the medical healthcare system worldwide, CI-AKI is still associated with direct short-term and indirect long-term outcomes including increased morbidity and mortality, specially, in patients under-lying pre-existing renal function impairment, cardiovascular disease or diabetes that could rap-idly progress into Chronic Kidney Disease. Although the RIFLE (Risk, Injury, Failure, Loss, End-Stage Kidney Disease), AKIN (Acute Kidney Injury Network) and KDIGO (Kidney Disease Improving Global Outcomes) clinical criteria and recommendation guidelines are based on tra-ditional “gold standard” biomarkers known as serum creatinine, glomerular filtration rate and urinary output, new reliable serum and urinary biomarkers are still needed for an effective uni-fied diagnostic strategy for AKI. Starting from previous and recent publications on the benefits and limitations of validated biomarkers responding to kidney injury, glomerular filtration and inflammation among others, this review unravels the role of new emerging biomarkers used alone or in combination, as reliable tools for early diagnosis and prognosis of CI-AKI, taking into account patients and procedures-risk factors towards a new clinical perspective.

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“…The use of contrast in addition to low cardiac output after suffering an acute myocardial infarction is associated with a worsening of renal function. (32,33) However, hypercholesterolemia is also associated with worsening renal function, and studies…”

Section: Crosstalk Between Heart and Kidney In The Use Of Contrastmentioning

confidence: 99%

Protective effect of apolipoprotein AI mimetic peptide 4F on renal and cardiac injury and endothelial dysfunction induced by acute myocardial infarction in hypercholesterolemic rats receiving iodinated contrast

Moreira,

Irigoyen,

Capcha

et al. 2024

Medicine: An Exploration of the Anatomy of the Human Body

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The use of contrast after angiography in infarcted animals induces acute kidney injury, being associated with worsening prognosis and increased mortality. Hypercholesterolemia is an aggravating factor of endothelial injury in acute myocardial infarction (AMI) and the use of contrast in diagnosis and treatment can cause acute kidney injury. Treatment with the apolipoprotein AI mimetic peptide 4F can reverse endothelial injury by reducing LDL levels and preventing its oxidation. OBJECTIVES: To analyze the effect of Apo A-I (using mimetic peptide 4F) on cardiac and renal injury induced by acute myocardial infarction (AMI) with contrast therapy in hypercholesterolemic rats. METHODS: This was a prospective study with rats on a diet at 4% cholesterol for 8 days, divided into a SHAM group operated without coronary ligation (n=6) or infarcted animals with ligation of the left anterior descending coronary artery, with or without the use of contrast and treatment 6 hours after infarction induction: AMI (n=15), AMI+C (iopamidol 2.9 g/kg body weight, intrafemoral artery injection n=15), AMI+4F (4F, 10mg/kg body weight, peritoneal injection, n=8) and AMI+C+4F (n=8). All results are analyzed after 24 AMI and expressed as mean and standard error. RESULTS: It was observed that the AMI+4F and AMI+C+4F groups showed a better response to cardiac injury and renal injury compared to the AMI and AMI+C groups. There was an improvement in renal function through 12-hour creatinine clearance, increased expression of eNOS, increased VEGF, preservation of mitochondrial morphology, reduction of inflammation with a lower expression of CD68+ (macrophages), decreased positive tunnel cells associated with an increase in apolipoprotein AI (Apo AI) expression in renal tissue. The same happened in cardiac function with decreased plasma troponin, increased expression of eNOS, VEGF, isolectin B4, reduction in inflammation represented by lower TLR4 expression, positive tunnel cells, improved cholesterol profile, preservation of mitochondrial morphology and associated with increased expression of Apo AI in cardiac tissue. Hemodynamics were preserved with improvement in cardiac output, ejection fraction, baroreflex response, left ventricular end-diastolic pressure, and associated with a decrease in the infarct area measured by both echocardiogram and immunohistochemistry. We demonstrate that treatment with apolipoprotein AI can be a therapeutic option in cardiac and renal injury by reversing the inflammatory response through the efflux of HDL-dependent cholesterol.

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Systemic and renal hemodynamic effects of intra-arterial radiocontrast

Cited by 6 publications

References 33 publications

Biomarkers in Contrast-Induced Acute Kidney Injury: Towards A New Perspective

Biomarkers in Contrast-Induced Acute Kidney Injury: Towards A New Perspective

Biomarkers in Contrast-Induced Acute Kidney Injury: Towards a new perspective.

Protective effect of apolipoprotein AI mimetic peptide 4F on renal and cardiac injury and endothelial dysfunction induced by acute myocardial infarction in hypercholesterolemic rats receiving iodinated contrast

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