Systemic associations of hidradenitis suppurativa

Kohorst, John J.; Kimball, Alexa B.; Davis, Mark D.P.

doi:10.1016/j.jaad.2015.07.055

Cited by 123 publications

(125 citation statements)

References 48 publications

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“…Nonobese HS patients report more frequent HS remission than obese patients (45 vs. 23%), and HS onset occurs at younger ages in patients with comorbid MetS. These findings suggest that African and Hispanic patients are at greater risk for MetS, chronic HS, and severer HS [6, 16]. Studies with larger sample sizes of African and Hispanic populations are needed to further assess this potentially significant relationship (Table 2).…”

Section: Metabolic Syndromementioning

confidence: 99%

“…HS has been associated with significant disability, embarrassment, and social isolation, as well as decreases in intimate relationships and sexual activity [17, 18], all of which lead to impaired QoL, depression, and anxiety [7, 16]. Depression is more prevalent in those with higher disease burden than those with medium disease burden (52 vs. 35%) [6].…”

Section: Depression and Qolmentioning

confidence: 99%

“…Depression is more prevalent in those with higher disease burden than those with medium disease burden (52 vs. 35%) [6]. HS patients have higher QoL impairment than patients with psoriasis, acne, neoplasms, strokes, and heart transplant candidates [6, 16, 17]. This has serious implications for African and Hispanic populations, who already have broader ranges of psychosocial stressors [19].…”

Section: Depression and Qolmentioning

confidence: 99%

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Hidradenitis Suppurativa: Disease Burden and Etiology in Skin of Color

2017

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Hidradenitis suppurativa (HS) is a chronic, debilitating skin disease. Although most studies on HS are conducted in largely Caucasian populations, evidence demonstrates a higher prevalence in patients with skin of color, including African and Hispanic populations. These racial subgroups are likely at risk for greater disease burden due to a higher prevalence of components of the metabolic syndrome, comorbid depression, and low socioeconomic status; however, there is a paucity of research in these populations. Additionally, studies examining the genetic and anatomical basis for HS, as well as the response to HS therapies, are lacking for patients with skin of color. Complicating this issue is the limited access to effective medical care, including dermatologists, for African and Hispanic populations as well as other minority groups. In this review, we identify gaps in the knowledge base, highlight the association between HS and patients with skin of color, and provide direction for much needed research into this condition.

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Section: Metabolic Syndromementioning

confidence: 99%

Section: Depression and Qolmentioning

confidence: 99%

Section: Depression and Qolmentioning

confidence: 99%

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Hidradenitis Suppurativa: Disease Burden and Etiology in Skin of Color

2017

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“…Moreover, other comorbidities have already been associated with HS, i.e. metabolic syndrome, inflammatory bowel disease, spondyloarthropathy, depression, non-melanoma skin cancer and pyoderma gangraenosum, diabetes mellitus, hypertriglyceridaemia, hypertension, pilonidal disease, acne vulgaris, hyperandrogenism, amyloidosis, anaemia and lymphoedema [6,7] .…”

Section: Introductionmentioning

confidence: 99%

Hospitalisations with Hidradenitis Suppurativa: An Increasing Problem That Deserves Closer Attention

Santos¹,

Lisboa²,

Lanna³

et al. 2016

Dermatology

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Background/Aims: Hidradenitis suppurativa (HS), a chronic inflammatory skin disease of the hair follicle, can lead to scarring and disability. With an estimated European prevalence of 1%, few epidemiological studies of HS have been performed, and none focused on hospitalisations. We aimed to study the time trends of HS hospitalisations and to evaluate the demographic characteristics, hospital incidence rate, readmissions, length of stay, comorbidities and risk factors of hospitalised HS patients. Methods: We performed a retrospective observational study using a national administrative database in Portugal, with discharges between 2000 and 2014. All the inpatients aged 5 years or more with a diagnosis of HS were included. Variables analysed were age, sex, admission and discharge date, discharge outcome and diagnoses. Results: A total of 1,177 patients were hospitalised in this time period (48 were aged 18 years or younger) with a male-to-female ratio of 1:1.17. There was a hospital incidence rate of 0.83 patients with HS per 100,000 person-years (95% CI = 0.78-0.88). The age group with the highest incidence rate was 20-29 years among women and 40-49 years among men. We recorded an increasing trend in the number of new hospitalised patients and in the hospital incidence rate of HS. Tobacco was the most common comorbidity/risk factor. Eighty-three percent of our population underwent HS surgery. Conclusion: This hospital-based incidence study showed that admission for HS is increasing and that the majority of the HS inpatients were surgical cases. In the future, prospective studies will be important to assess risk factors for hospitalisations and complications.

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“…Somit haben CED-Patienten ein 9-fach erhöhtes Risiko gegenüber der Normalbevölkerung, an einer HS zu erkranken [20].…”

Section: » Der Schweregrad Der Erkrankung Muss Genau Definiert Werdenunclassified