2013
DOI: 10.3109/09273948.2012.723110
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Systemic Atopy and Immunoglobulin Deficiency in Turkish Patients with Vernal Keratoconjunctivitis

Abstract: IgE-mediated mechanisms are involved in approximately 40% of VKC patients. A new finding was the higher incidence of Ig deficiency.

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Cited by 12 publications
(18 citation statements)
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“…Overall, 69.3% were males, and the mean age of patient was 9.8 years (range, [7][8][9][10][11][12][13][14][15][16][17][18][19]. There was no statistically significant difference between the two groups in terms of sex or mean age (p > 0.05).…”
Section: Resultsmentioning
confidence: 99%
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“…Overall, 69.3% were males, and the mean age of patient was 9.8 years (range, [7][8][9][10][11][12][13][14][15][16][17][18][19]. There was no statistically significant difference between the two groups in terms of sex or mean age (p > 0.05).…”
Section: Resultsmentioning
confidence: 99%
“…Conventionally, VKC was considered primarily a type 1 hypersensitivity reaction. However, approximately 50% of the patients with VKC have no familial or personal history of atopy, and a large proportion have negative results on the Standard allergic diagnostic tests, confirming that it is not solely immunoglobulin E (IgE)-mediated [10]. Recent studies suggest a more complex non-IgE-dependent pathogenic mechanism.…”
mentioning
confidence: 99%
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“…Each patient gave written informed consent, assisted by a translator where appropriate, to participate in this study, to provide blood samples and demographic as well as clinical data. Participants aged [15][16][17][18] years gave written assent to be a participant and a parent or guardian gave written informed consent.…”
Section: Design and Subjectsmentioning
confidence: 99%
“…[3][4][5] Steroids are being used as the mainstay of treatment for VKC, but a standard treatment protocol is not yet established. Steroids are very effective in controlling the acute exacerbation, but they may cause intraocular pressure elevation in steroid-responders, risk of corneal infection, and cataract.…”
Section: Introductionmentioning
confidence: 99%