Systemic Autoimmune Diseases: Not So Rare in Black Africans

Adelowo, MKN Bello O O

doi:10.4172/2161-1149.1000130

Cited by 9 publications

(9 citation statements)

References 34 publications

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“…Systemic lupus erythematosus is a condition that affects females of reproductive age and has a wide range of clinical manifestations. Despite reports that SLE is rare in Negro Africans [5], several studies have suggested that the burden of SLE is higher than previously thought [9,14,[16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Clinical and laboratory profile of systemic lupus erythematosus patients at a rural tertiary centre in South-South Nigeria: experience from a new rheumatology clinic

Emorinken¹,

Dic-Ijiewere²,

Erameh³

et al. 2021

Reumatologia

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Objectives: Systemic lupus erythematosus (SLE) is an autoimmune disorder with a poorly understood aetiology. It predominantly affects females and has a variety of clinical manifestations. In Nigeria, there are limited data on the prevalence and burden of the disease. This study aimed to determine the clinical and laboratory profiles of SLE patients seen in a new rheumatology clinic in South-South Nigeria. Material and methods: This was a retrospective cross-sectional study conducted over five years (January 2016 to December 2020). The case files of patients that satisfied the diagnosis of SLE were reviewed. The diagnosis was based on the 1997 update of the American College of Rheumatology revised criteria for the classification of SLE. The sociodemographic, clinical, and immunological data were extracted from case records. Data analysis was carried out using IBM SPSS statistics® 2012 version 21.0. Results: Fifty-two patients were diagnosed with SLE, giving a frequency of 4.7%. Forty-seven (90.4%) of the study participants were females, with a female-to-male ratio of 9.4 : 1. The mean age of the study group was 28.42 years. The mean duration of disease before diagnosis was 4.04 months with a range of 1-15 months. The patients had various organ system manifestations, with polyarthritis being the commonest (86.5%). Others included mucocutaneous (78.8%), haematological (69.2%), serositis (40.4%), renal (38.5%), and neurological (25%) manifestations. Antinuclear antibody (ANA) assay and anti-double-stranded DNA were positive in 100% and 69.2% of patients, respectively. All patients were placed on steroids, and 96.2% had hydroxychloroquine. None of the patients were on biologic disease-modifying antirheumatic drugs. Conclusions: This study's results are consistent with data from other African countries. To fully understand the burden and epidemiology of SLE in Nigeria, a larger prospective study is needed.

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Section: Discussionmentioning

confidence: 99%

Clinical and laboratory profile of systemic lupus erythematosus patients at a rural tertiary centre in South-South Nigeria: experience from a new rheumatology clinic

Emorinken¹,

Dic-Ijiewere²,

Erameh³

et al. 2021

Reumatologia

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“…However, the frequency of the systemic auto-immune diseases was likely to be under-estimated in Africa [3]. Indeed, In Africa, south of the Sahara, these affections are not a concern due to priority areas such as infectious and tropical diseases [4].…”

Section: Introductionmentioning

confidence: 99%

Systemic Diseases in Dakar (Senegal): Spectrum, Epidemiological Aspect and Diagnostic Time-Limit

Kane¹,

Niasse²,

Ndiaye³

et al. 2018

OJIM

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“…Arriving at the root diagnosis of such cases in most centres in West Africa could be delayed. This is partly due to the erstwhile belief that connective tissue diseases are very rare in sub-Saharan Africa [9]. As such many cases of SSc may not be recognized until cutaneous manifestations are florid.…”

Section: Discussionmentioning

confidence: 99%

Fatal Cardiac Tamponade in Newly Diagnosed Systemic Sclerosis with Early Cutaneous Disease: A Case Report

Oluyinka¹

2017

JRAD

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Systemic Autoimmune Diseases: Not So Rare in Black Africans

Cited by 9 publications

References 34 publications

Clinical and laboratory profile of systemic lupus erythematosus patients at a rural tertiary centre in South-South Nigeria: experience from a new rheumatology clinic

Clinical and laboratory profile of systemic lupus erythematosus patients at a rural tertiary centre in South-South Nigeria: experience from a new rheumatology clinic

Systemic Diseases in Dakar (Senegal): Spectrum, Epidemiological Aspect and Diagnostic Time-Limit

Fatal Cardiac Tamponade in Newly Diagnosed Systemic Sclerosis with Early Cutaneous Disease: A Case Report

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