Systemic Candida infection in preterm babies: Experience from a tertiary care hospital of North India

Charoo, Bashir Ahmad; Ashraf, Younis; Bhat, Javeed I.; Qazi, Iqbal Ahmad

doi:10.4103/jcn.jcn_9_19

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…Among the non-albicans species, C. guilliermondii was the most frequent, accounting for 15% of cases. Additionally, 16 The gold standard for diagnosing IC is culture, yet the sensitivity of blood culture and ascitic fluid is reported to be insignificant. This could be due to the common practice of empiric antifungal therapy.…”

Section: Resultsmentioning

confidence: 99%

Epidemiology and antifungal susceptibility patterns of invasive candidiasis: A single-center study

Younas,

Iftikhar,

Rasool

2024

Infect Dis J Pak

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Background: Invasive candidiasis remains a leading cause of morbidity and mortality. Despite the availability of various antifungal treatments, global reports continue to highlight resistance, treatment ineffectiveness, and outbreaks. This study aimed to analyze the epidemiology of various Candida species isolated from invasive samples and assess their antifungal susceptibility profiles. Material and Methods: The study identified and evaluated a total of 200 Candida isolates, recovered over a 6-month period from various clinical specimens. These were assessed against various antifungals according to recommendations. Results: Among the samples, blood (79%) and pus (12%) were the most commonly encountered sources of Candida isolation. Candida isolates comprised 14.5% (30) C. albicans and 85.5% (170) non-albicans species. Non-albicans species included 15% (30) C. guilliermondii, 14.5% (29) C. lusitaniae, 11.5% (22) C. tropicalis, 2.3% (4) C. auris, and 8.5% (17) C. parapsilosis. Overall, the strains showed 74% and 91% sensitivity to Fluconazole and Voriconazole, respectively, and 100% sensitivity to Caspofungin and Amphotericin B, with the exception of C. lusitaniae. Conclusion: The susceptibility profile of antifungals is evolving. This study demonstrated a low rate of resistance to four antifungals in invasive candidiasis in Pakistan. None of the isolates were resistant to more than one drug. Early and prompt treatment through the implementation of an antifungal stewardship program and strict infection control is crucial. Keywords: Invasive candidiasis (IC), Antifungal susceptibility profile, Fluconazole, Candidemia

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Section: Resultsmentioning

confidence: 99%

Epidemiology and antifungal susceptibility patterns of invasive candidiasis: A single-center study

Younas,

Iftikhar,

Rasool

2024

Infect Dis J Pak

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Epidemiology, risk factors and outcomes associated with candidaemia in very low birth weight infants at a tertiary South African Hospital over a 7-year period (2013–2019)

Ramdin

Saggers²,

Bandini³

et al. 2023

Clinical Epidemiology and Global Health

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Prevalence of Ocular Candidiasis and Candida Endophthalmitis in Patients With Candidemia: A Systematic Review and Meta-Analysis

Phongkhun

Pothikamjorn

Srisurapanont

et al. 2023

Clinical Infectious Diseases

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Background Infectious diseases and ophthalmology professional societies have disagreed regarding ocular screening in patients with candidemia. This study aimed to summarize the current evidence on the prevalence of ocular candidiasis (OC) and Candida endophthalmitis (CE) according to the standardized definitions. Methods A literature search was conducted from the 1990s through October 16th, 2022, using PubMed, Embase, and SCOPUS. Pooled prevalence of ocular complications was derived from generalized linear mixed models. (PROSPERO CRD42022326610) Results A total of 70 and 35 studies were included in the meta-analysis for OC and concordant CE (chorioretinitis with vitreous involvement), respectively. This study represented 8,599 patients with candidemia who underwent ophthalmologic examination. The pooled prevalence [95% confidence interval] of OC, overall CE, concordant CE, and discordant CE were 10.7% [8.4%-13.5%], 3.1% [2.1%-4.5%], 1.8% [1.3%-2.6%], and 7.4% [4.5%-12%] of patients screened, respectively. Studies from Asian countries had significantly higher concordant CE prevalence of patients screened [95% CI] of 3.6% [2.9% - 4.6%] compared to studies from European countries of 1.4% [0.4% - 5%] and American countries of 1.4% [0.9% - 2.2%], p-value <0.01. Presence of total parenteral nutrition and C. albicans were associated with CE with pooled odds ratios [95% CI] of 6.92 [3.58–13.36] and 3.02 [1.67–5.46], respectively. Conclusion Prevalence of concordant CE overall and among Asian countries was two-times and four-times higher than the prevalence previously reported by American Academy of Ophthalmology of < 0.9%, respectively. There is an urgent need to study optimal screening protocols and to establish joint recommendations by the Infectious Diseases and Ophthalmology Societies.

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Systemic Candida infection in preterm babies: Experience from a tertiary care hospital of North India

Cited by 4 publications

References 14 publications

Epidemiology and antifungal susceptibility patterns of invasive candidiasis: A single-center study

Epidemiology and antifungal susceptibility patterns of invasive candidiasis: A single-center study

Epidemiology, risk factors and outcomes associated with candidaemia in very low birth weight infants at a tertiary South African Hospital over a 7-year period (2013–2019)

Prevalence of Ocular Candidiasis and Candida Endophthalmitis in Patients With Candidemia: A Systematic Review and Meta-Analysis

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