Systemic chemotherapy and tamoxifen induced regression of choroidal metastasis from a breast carcinoma in a male

Shome, Debraj; Jayadev, Chaitra; Gadgil, Darshana; Natarajan, Sundaram; Jain, Vandana

doi:10.4103/0301-4738.36491

Cited by 12 publications

(6 citation statements)

References 5 publications

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“…Overall, we concur with earlier reports of a conservative approach for choroidal metastatic lesions in disseminated breast carcinoma while on chemotherapy [ 9 – 11 , 28 , 29 ], Additionally, we suggest the consideration of vinorelbine therapy in patients with choroidal metastasis, irrespective of hormone receptor status and responsiveness to antiestrogen therapy in disseminated breast malignancy, thereby limiting local radiation therapy to vision threatening lesions only.…”

Section: Discussionsupporting

confidence: 91%

Vinorelbine-induced regression of a choroidal metastasis from primary breast carcinoma

Arya

Duker

2018

Int J Retin Vitr

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Background Various therapeutic options exist to treat choroidal metastatic lesions. However, they are all associated with potential long-term adverse effects. This case report discusses a case of choroidal metastasis from primary breast carcinoma that regressed after single-agent chemotherapy.Case presentationWe report a case of choroidal metastasis from estrogen receptor (ER) positive breast carcinoma that became resistant to endocrine therapy. The primary malignancy was treated with surgical resection and adjuvant chemoradiation, followed by hormone therapy with various agents in combination with kinase inhibitors for ER resistance. The choroidal metastatic lesion regressed after the initiation of vinorelbine. Vinorelbine is a cytotoxic vinca alkaloid with tolerable systemic adverse effects.ConclusionsThis case report highlights the possible role of vinorelbine as a single chemotherapeutic agent for the conservative therapy of uveal metastasis from advanced breast carcinoma, irrespective of responsiveness to hormone therapy.

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Section: Discussionsupporting

confidence: 91%

Vinorelbine-induced regression of a choroidal metastasis from primary breast carcinoma

Arya

Duker

2018

Int J Retin Vitr

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“…[ 39 ] Regression of choroidal metastasis from breast and lung carcinoma after systemic chemotherapy has been noted. [ 40 41 42 43 ] In a study of 4 patients with choroidal metastasis treated with systemic chemotherapy alone, tumor regression occurred in 3 patients. [ 44 ]…”

Section: Systemic Treatmentmentioning

confidence: 99%

Choroidal metastases: Origin, features, and therapy

Arepalli¹,

Kaliki²,

Shields³

2015

Indian J Ophthalmol

147

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The choroid is the most common ocular site for metastatic disease, owing to abundant vascular supply. The primary cancers that most commonly lead to choroidal metastases include breast cancer (40-47%) and lung cancer (21-29%). Bilateral, multifocal metastases are most often secondary to breast cancer, whereas unilateral, unifocal metastasis are more commonly found with lung cancer. The treatment of choroidal metastasis depends on the systemic status of the patient and number, location, and laterality of the choroidal tumors. Treatment options include observation in patients with poor systemic status or those with resolved or asymptomatic disease; systemic chemotherapy, immunotherapy, hormone therapy, or whole eye radiotherapy if the metastases are active, multifocal and bilateral; plaque radiotherapy, transpupillary radiotherapy, or photodynamic therapy for active, solitary metastasis; and enucleation for those with blind painful eye. A database search was performed on PubMed, using the terms “choroidal metastasis,” or “choroidal metastases,” in combination with terms such as “treatment,” “features,” or “diagnosis.” Relevant articles were extracted and reviewed.

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“…A higher concentration of estrogen and progesterone receptors in male breast cancer may make it more susceptible to hormonal treatment. Regression of choroidal metastases in male breast cancer has been reported with systemic chemotherapy (18), as well as with hormonal therapy alone (11,19). If choroidal metastases are unresponsive to systemic therapy, as in all cases reported here, radiotherapy is the treatment of choice for palliation of ocular symptoms.…”

Section: Hood Et Almentioning

confidence: 62%

Male Breast Carcinoma Metastatic to the Choroid: Report of 3 Cases and Review of the Literature

Hood

Budd

Zakov

et al. 2010

European Journal of Ophthalmology

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Systemic chemotherapy and tamoxifen induced regression of choroidal metastasis from a breast carcinoma in a male

Cited by 12 publications

References 5 publications

Vinorelbine-induced regression of a choroidal metastasis from primary breast carcinoma

Vinorelbine-induced regression of a choroidal metastasis from primary breast carcinoma

Choroidal metastases: Origin, features, and therapy

Male Breast Carcinoma Metastatic to the Choroid: Report of 3 Cases and Review of the Literature

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