Systemic connective tissue abnormalities in patients with saccular intracranial aneurysms

Lebedeva, Elena R.; Сакович, В. П.

doi:10.1111/ane.12088

Cited by 4 publications

(5 citation statements)

References 22 publications

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“…This can, however, explain only a small part of the increased risk of migraine without aura in SIA patients. SIA is associated with an increased prevalence of systemic connective tissue abnormalities [16] but in the present study there was no difference in the prevalence of MO in SIA patients with or without connective tissue abnormalities. Thus, systemic factors can explain only a small part of the increased prevalence of migraine in SIA patients.…”

Section: Discussioncontrasting

confidence: 78%

“…Hypertension was defined as a history of high blood pressure (systolic values ≥140 mm Hg and/or diastolic pressure ≥90 mm Hg) or, if physician observed blood pressure of 140/90 mmHg or above on three consecutive measurements at least six hours apart. Systemic connective tissue dysplasia (CTD) was defined if patient had 3 or more visible markers of connective tissue dysplasia [16]. Smoking was categorized as follows: never smoked, former (regular) cigarette smokers, and current cigarette smoker.…”

Section: Methodsmentioning

confidence: 99%

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Migraine before rupture of intracranial aneurysms

et al. 2013

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BackgroundRupture of a saccular intracranial aneurysm (SIA) causes thunderclap headache but it remains unclear whether headache in general and migraine in particular are more prevalent in patients with unruptured SIA.MethodsIn a prospective case–control study 199 consecutive patients with SIA (103 females and 96 males, mean age: 43.2 years) received a semistructured face to face interview focusing on past headaches. All were admitted to hospital mostly because of rupture (177) or for unruptured aneurysm (22). In parallel we interviewed 194 blood donors (86 females, 108 males, mean age: 38.4 years). Diagnoses were made according to the International Headache Society criteria. Aneurysms were diagnosed by conventional cerebral angiography.ResultsDuring the year before rupture, 124 (62.3%) had one or more types of headache. These headaches included: migraine without aura (MO): 78 (39.2%), migraine with aura (MA): 2 (1%), probable migraine (PM): 4 (2%), tension-type headache (TTH): 39 (19.6%), cluster headache (CH): 2 (1%), posttraumatic headaches (PH): 2 (1%). 1-year prevalence of headaches in controls was 32.5% (63 patients out of 194), they included: TTH: 45 (23.1%), MO: 17(8.8%), PH: 1(0.5%). Only the prevalence of MO was significantly higher in patients with SIA (OR 6.7, 95% CI 3.8-11.9, p < 0.0001).ConclusionsUnruptured SIA cause a marked increase in the prevalence of migraine without aura but not in the prevalence of other types of headache.

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Section: Discussioncontrasting

confidence: 78%

Section: Methodsmentioning

confidence: 99%

Migraine before rupture of intracranial aneurysms

et al. 2013

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“…No unpublished or ongoing studies were identified. From the 53 articles selected for full‐text review, thirteen were excluded because they did not report on periodontal manifestations in EDS (Barabas, ; Hoff, ; Jensen & Storhaug, ; Kobayasi, Oguchi, & Asboe‐Hansen, ; Lebedeva & Sakovich, ; Letourneau, Perusse, & Buithieu, ; Leung, Barksy, & Lewkonia, ; Mantle, Wilkins, & Preedy, ; Ooshima, Abe, Kohno, Izumitani, & Sobue, ; Parrini et al., ; Recant & Lipman, ; Selliseth, ); one case report was published as periodontal EDS (pEDS), but in fact, no periodontal manifestations were reported (Serman & Albert, ). In total, 43 articles were finally included.…”

Section: Resultsmentioning

confidence: 99%

Periodontal manifestations of Ehlers–Danlos syndromes: A systematic review

Kapferer-Seebacher

Lundberg

Malfait

et al. 2017

J Clinic Periodontology

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“…Дизайн исследования состоял из следующих этапов: Сбор данных катамнеза заболевания, анамнеза жизни больных и их родословных осуществлялся в процессе интервью, при клиническом осмотре больных, а также при анализе медицинской документации, данных магниторе зонансной и компьютерной томографий головного мозга и результатов дополнительных обследований, включающих клинический осмотр, измерение артериального давления, пульса. С целью определения признаков соединительно тканной патологии у всех больных с интракраниаль ными аневризмами и пациентов контрольной группы общий осмотр проведен по особой методике (Lebedeva, Sakovich, 2013). Он включал определение конституции, роста, веса, растяжимости кожи над серединой ключицы в положении стоя и толщины кожной складки на тыле кисти.…”

Section: материалы и методыunclassified

Association of vascular endothelial growth factor B (VEGFВ) gene polymorphisms with intracranial aneurysms

et al. 2019

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Intracranial aneurysm (IA) is a complex disease resulting in subarachnoid hemorrhage (SAH) due to a rupture. The average worldwide prevalence of this disease is about 2–5 %, with 50 % of them ending in death or neurological disorders of varying severity, with a high probability of recurrence of hemorrhage during the frst half of the year after rupture. Subarachnoid hemorrhage is annually registered in at least 18 thousand people in Russia. Associations of polymorphic variantsrs594942andrs11603042of theVEGFBgene in intracranial aneurysm development in the Volga-Ural region of the Russian Federation with the presence of the symptom complex of undiﬀerentiated connective tissue dysplasia (uDST) and arterial hypertension (AH) were investigated. TheC* allelers594942andrs11603042of theVEGFBgene is a marker of an increased risk of IA as a whole (p= 0.025; χ2 = 5.052; OR = 1.32) in women as a whole (p= 0.001; χ2 = 10.124; OR = 1.70) and in comorbid state with uDCT (p= 0.002; χ2 = 9.501; OR = 2.34) and AG (p= 0.006; χ2 = 7.385; OR = 2.109). We found that the genotype *C*Cof locusrs594942of theVEGFBgene is a marker of an increased risk of intracranial aneurysm in general (p= 0.017; χ2 = 5.702; OR = 1.49) and among women in general (p= 0.0005; χ2 = 12.078; OR = 2.25) and with the symptomatic complex uCTD (p= 0.007; χ2 = 7.173; OR = 2.67) and AH (p= 0.010; χ2 = 6.471; OR = 2.51). We have obtained new results on the role of polymorphic variants of theVEGFBgene in the formation of intracranial aneurysm, taking into account the presence of the symptom complex uDCT and AH among the residents of the Volga-Ural region of Russia. A burdened comorbid background and the presence of undiﬀerentiated connective tissue dysplasia and arterial hypertension can contribute to an increased risk of intracranial aneurysm, as evidenced by the results of our study.

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Systemic connective tissue abnormalities in patients with saccular intracranial aneurysms

Abstract: Patients with SIA have multiple markers of systemic connective tissue abnormalities. Systemic weakness of connective tissue represents a risk factor for development of SIA. Identification of these markers may help in detection of high-risk patients.

Cited by 4 publications

References 22 publications

Migraine before rupture of intracranial aneurysms

Migraine before rupture of intracranial aneurysms

Periodontal manifestations of Ehlers–Danlos syndromes: A systematic review

Association of vascular endothelial growth factor B (VEGFВ) gene polymorphisms with intracranial aneurysms

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