Systemic Cytokine Profiles in Strongyloides stercoralis Infection and Alterations following Treatment

Ray, Anuradha; Munisankar, Saravanan; Bhootra, Yukti; Jagannathan, Jeeva; Dolla, Chandrakumar; Kumaran, Paul; Shen, Kui; Nutman, Thomas B.; Babu, Subash

doi:10.1128/iai.01354-15

Cited by 45 publications

(43 citation statements)

References 39 publications

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“…It is also higher in patients with sputum smear Mtb, and a short-term anti-TB chemotherapy significantly reduce IL-37. Our findings appear to consist with the recent reports indicating that increases in IL-37 expression in infections including HIV-1 and HBV infections are associated with viral loads and inflammation (Anuradha et al, 2015; Hojen et al, 2015; Huang et al, 2015; Li et al, 2013; van de Veerdonk et al, 2014). …”

Section: Discussionsupporting

confidence: 91%

Tuberculosis-sensitized monocytes sustain immune response of interleukin-37

Zhang

Liu

Zheng

et al. 2016

Molecular Immunology

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Roles of human IL-37 in infections remain poorly characterized. Although plasma IL-37 is elevated in patients with tuberculosis (TB), IL-37 source and immune correlate in TB have not been investigated. It is also unknown whether and how TB can influence the ability of immune cells to mount innate responses of IL-37 and pre-inflammatory cytokines. Here, we demonstrated that IL-37b-producing monocytes coincided with a source of elevated plasma IL-37b in TB patients. While IL-37b production in TB was associated with prolonged/complicated TB, TB burdens and inflammatory reactions, it negatively correlated with immune responses of proinflammatory cytokines IL-1β, IL-6 and TNF-α or IL-10. Interestingly, mycobacterial re-infection of monocytes from TB patients, but not healthy BCG-vaccinated controls, enhanced or sustained IL-37b production by cultured monocytes. TB-sensitized monocytes from TB patients mounted more robust immune responses of IL-37b than those of pre-inflammatory cytokines during mycobacterial re-infection in culture. Our data represent new findings in terms of IL-37b responses, immune correlates and potential mechanisms in TB patients.

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Section: Discussionsupporting

confidence: 91%

Tuberculosis-sensitized monocytes sustain immune response of interleukin-37

Zhang

Liu

Zheng

et al. 2016

Molecular Immunology

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“…It is postulated that helminth infections may exert an evolutionary advantage by maintaining host immune tolerance through immune-modulation pathways. A recently published paper studied the cytokine profile of asymptomatic infected individuals and found that they had significantly lower circulating levels of pro-inflammatory cytokines and significantly higher levels of anti-inflammatory cytokines [34]. The worms' anti-inflammatory properties may result in reduced insulin resistance.…”

Section: Immunomodulationmentioning

confidence: 99%

Do worms protect against the metabolic syndrome? A systematic review and meta-analysis

Tracey

McDermott

McDonald

2016

Diabetes Research and Clinical Practice

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“…IL-37 is involved in the suppression of innate and adaptive immunity (Boraschi et al 2011;Chen and Fujita 2015;Ye et al 2014). Recent reports indicate that IL-37 plays important roles in inflammatory disease (Charrad et al 2016;Ye et al 2014;Zhao et al 2014b), infectious disease (Anuradha et al 2016;Hojen et al 2015;Samarani et al 2016), cancer (Ding et al 2016;Ge et al 2016) and angiocardiopathy (Huang et al 2016;Yu et al 2016). However, the exact mechanisms of IL-37 in human disease remain to be further studied.…”

Section: Discussionmentioning

confidence: 99%

Development and characterization of monoclonal antibody against human IL-37b

et al. 2017

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IL-37 has been described as a natural inhibitor of immune responses. Monoclonal antibody (mAb) against human IL-37b with high affinity and specificity can serve as a molecular probe to detect IL-37 and study IL-37 functions, mechanisms and related signal pathways in inflammatory diseases. However, there are very few such mAbs against human IL-37 commercially available so far. In the current study, monoclonal antibodies against human IL-37b were developed by fusing splenocytes from immunized mouse with SP2/0 myeloma cells and polyethylene glycol. Then the antibodies were screened with prokaryotic expressed human IL-37b protein and eukaryotic expressed human IL-37b protein subsequently. Western blot and flow cytometry analysis revealed that selected mAb clons were able to recognize human IL-37 with high specificity. And more importantly, the IL-37b mAbs were fluorescently labeled and can be directly used in flow cytometry and immunohistochemistry. In conclusion, the current study developed new mAbs against human IL-37b, which are applicable in flow cytometry and immunohistochemistry.

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Systemic Cytokine Profiles in Strongyloides stercoralis Infection and Alterations following Treatment

Cited by 45 publications

References 39 publications

Tuberculosis-sensitized monocytes sustain immune response of interleukin-37

Tuberculosis-sensitized monocytes sustain immune response of interleukin-37

Do worms protect against the metabolic syndrome? A systematic review and meta-analysis

Development and characterization of monoclonal antibody against human IL-37b

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