Systemic disease associations with angioid streaks in a large healthcare claims database

Nadelmann, Jennifer; Li, Yafeng; McGeehan, Brendan; Yu, Yinxi; VanderBeek, Brian L.

doi:10.1038/s41433-022-02189-x

Cited by 6 publications

(7 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nadelmann et al suggested that the classical associations of ASs with PXE, hemoglobinopathies, and Paget were observed at a far lower rate than in previous studies [ 22 ]. Moreover, they suggested that there was a statistically higher prevalence of the following less classically associated diseases among patients with ASs compared to controls: hereditary spherocytosis (1.7% vs. 0.6%, p < 0.001), connective tissue disease (1.0% vs. 0.3%, p < 0.001), and non-exudative age-related macular degeneration (AMD) (33.9% vs. 10.6%, p < 0.001) [ 22 ]. This suggests potential new connections between ASs and systemic diseases, potentially illuminating the mechanisms behind AS formation.…”

Section: Narrative Review Findingsmentioning

confidence: 84%

“…Furthermore, he suggested that the frequency of any underlying associated systemic disease will depend on the clinician’s effort and use of different tests to identify such disease, which can vary from skin biopsy to genetic testing [ 8 ]. However, in a more recent study from the United States published in June 2023 that represents the largest collection of AS patients to date [ 22 ], Nadelmann et al reported a percentage of 12.3% [ 22 ].…”

Section: Narrative Review Findingsmentioning

confidence: 99%

“…In Paget’s disease, Dabbs et al reported that the frequency of ASs may vary from 8% to 15% [ 3 , 23 ]. On the other hand, Nadelmann et al reported a much smaller percentage of 0.3% [ 22 ].…”

Section: Narrative Review Findingsmentioning

confidence: 99%

“…Finally, the frequency of ASs in beta thalassemia increases with age and may reach up to 30% in patients with the disease above the age of 50 [ 8 , 29 ]. On the other hand, Nadelmann et al reported that the prevalence rate of hemoglobinopathies was 1.6% [ 22 ].…”

Section: Narrative Review Findingsmentioning

confidence: 99%

“…This process is accompanied by the activation and migration of the retinal pigment epithelium (RPE) to different retinal layers, which, upon disruption of BrM’s mechanical integrity, results in the degeneration and atrophy of the overlying RPE. These insights may offer further understanding of the underlying pathways leading to the development of ASs [ 3 , 22 ].…”

Section: Narrative Review Findingsmentioning

confidence: 99%

See 4 more Smart Citations

Angioid Streaks Remain a Challenge in Diagnosis, Management, and Treatment

Tsokolas,

Tossounis,

Tyradellis

et al. 2024

Vision

View full text Add to dashboard Cite

Aim: Angioid streaks (ASs) are a rare retinal condition and compromise visual acuity when complicated with choroidal neovascularization (CNV). They represent crack-like dehiscences at the level of the Bruch’s membrane. This objective narrative review aims to provide an overview of pathophysiology, current treatment modalities, and future perspectives on this condition. Materials and Methods: A literature search was performed using “PubMed”, “Web of Science”, “Scopus”, “ScienceDirect”, “Google Scholar”, “medRxiv”, and “bioRxiv.” Results: ASs may be idiopathic, but they are also associated with systemic conditions, such as pseudoxanthoma elasticum, hereditary hemoglobinopathies, or Paget’s disease. Currently, the main treatment is the use of anti-vascular endothelial growth factors (anti-VEGF) to treat secondary CNV, which is the major complication observed in this condition. If CNV is detected and treated promptly, patients with ASs have a good chance of maintaining functional vision. Other treatment modalities have been tried but have shown limited benefit and, therefore, have not managed to be more widely accepted. Conclusion: In summary, although there is no definitive cure yet, the use of anti-VEGF treatment for secondary CNV has provided the opportunity to maintain functional vision in individuals with AS, provided that CNV is detected and treated early.

show abstract

Section: Narrative Review Findingsmentioning

confidence: 84%