Systemic drug-related intertriginous and flexural exanthema induced by the Pfizer-BioNTech COVID-19 vaccine: A report of 2 cases

Symmetric drug–related intertriginous and flexural exanthema–like eruption related to coronavirus disease 2019 vaccine

“…Reports of COVID‐19 vaccination‐related SDRIFE are rare. 2 , 3 , 4 , 5 To date, five cases induced by an inactivated whole‐virus vaccine (CoronaVac [Sinovac Life Sciences]), messenger RNA (mRNA) vaccine (BNT162b2), and adenoviral vaccine (ChAdOx1 nCoV‐19) have been published (Table 1 ). Although it is not possible to discern the immunological mechanism of vaccine‐associated SDRIFE, it is considered a type IVc and IVd delayed‐type systemic allergic dermatitis.…”

“…Cutaneous reactions after COVID‐19 vaccines, such as adenoviral (including ChAdOx1 nCoV‐19) and messenger RNA (mRNA) vaccines (including BNT162b2; [Pfizer‐BioNTech] and mRNA‐1273 [Moderna Biotech), have been observed. Reports of COVID‐19 vaccination‐related SDRIFE are rare 2‐5 . To date, five cases induced by an inactivated whole‐virus vaccine (CoronaVac [Sinovac Life Sciences]), messenger RNA (mRNA) vaccine (BNT162b2), and adenoviral vaccine (ChAdOx1 nCoV‐19) have been published (Table 1).…”

“…11 The CoronaVac and BNT162b2 vaccines have shared components including sodium chloride and disodium hydrogen phosphates. 3 These components are also included in many other vaccines; however, there are no previous reports of SDRIFE-like skin eruptions associated with these components. Therefore, the possibility of these being the causative agent seems relatively low.…”

Symmetrical drug‐related intertriginous and flexural exanthema‐like eruption after COVID‐19 vaccine

“…To our knowledge, there are only four recent reported cases of SDRIFE‐like eruption related to COVID‐19 vaccines Oxford/Astrazeneca (chAdOx1‐S Covid 19 Vaccine). 1 , 2 , 3 SDRIFE is a drug‐related type IV hypersensitivity eruption that involves the intertriginous or flexural folds and the gluteal area. It has been reported in association with beta‐lactams, antihypertensives and chemotherapeutic agents.…”

A case of symmetrical drug‐related intertriginous and flexural exanthema‐like eruption associated with Pfizer COVID ‐19 vaccination

“…Four cases of SDRIFE‐like eruption due to COVID‐19 vaccination have been reported to date (Table 1 ), the first associated with the CoronaVac vaccine, which contains an inactivated form of the COVID‐19 virus, 5 the second with the Oxford‐AstraZeneca mRNA vaccine, 6 and the other two recently reported with the Pfizer–BioNTech mRNA vaccine. 7 …”