Systemic effects associated with intermittent claudication. A model to study biochemical aspects of vascular disease?

Microalbuminuria in Nondiabetic Patients with Acute Ischemic Stroke: Prevalence, Clinical Correlates, and Prognostic Significance

“…The current study was unable to measure UAE serially, therefore the lower prevalence of MA measured in stroke survivors (16%) and in controls (16.7%), despite the similar profile of risk factors for stroke, is an indirect confirmation of a transient MA measured only in the acute stroke period. It has been shown that a sudden and transient increase in UAE can appear in patients with peripheral vascular disease during an episode of intermittent claudication [20]and in patients with positive exercise electrocardiogram tests during the exercises [21]. These studies suggest that even minor ischemic episodes of short duration and without serious sequelae can be accompanied by an increase in albuminuria.…”

Intestinal permeability is increased in patients with intermittent claudication

“…For example, urinary microalbumin concentration, serum thromboxane A2, urinary thromboxane metabolites, serum lipid peroxidase levels suggesting oxygen-derived free radicals activity, serum amyloid A protein, and C-reactive protein are evaluated. [14][15][16][17] The L/M test is based on the different absorption routes of two sugars. Lactulose and mannitol are nonmetabolized low-molecular-weight sugars: lactulose is a disaccharide with a molecular weight of 342, and mannitol is a monosaccharide with a molecular weight of 182.…”

“…Shearman et al 15 have reported that urinary microalbumin concentration after treadmill exercise gives some information about metabolic change. They showed that urinary microalbumin concentrations increase after treadmill exercise in patients with intermittent claudication.…”

El impacto de la enfermedad arterial periférica: propuesta de una nueva clasificación

“…Los efectos ocultos que se producen en el organismo como consecuencia del estré s oxidativo durante la marcha de los claudicantes son todavía má s numerosos, pudiendo demostrarse la presencia de microalbuminuria, indicador de aumento de la permeabilidad del glomé rulo renal, un fenó meno encuadrado en el contexto de un incremento generalizado de la permeabilidad vascular 38 . De todas maneras la microalbuminuria en otras ocasiones no aparece durante la marcha, pero sí aparece la enzima NAG en proporciones estadísticamente significativas, con perfil de marcador má s grave, en estados má s avanzados de isquemia crítica, con grave riesgo de provocar disfunció n renal 39 .…”