2018
DOI: 10.1038/bjc.2018.7
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Systemic immune-inflammation index in germ-cell tumours: search for a biological prognostic biomarker

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Cited by 19 publications
(13 citation statements)
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“…In addition, our study is novel in its incorporation of SII, a comprehensive hematological index based on the peripheral platelet, neutrophil, and lymphocyte counts, with prognostic significance. SII has already been demonstrated as a strong prognostic predictor in a variety of malignant tumors, [28][29][30][31] including NSCLC managed with chemoradiotherapy or surgery, [12][13][14][15] and our study is the first to date evaluating its predictive value in the setting of SABR for ES-NSCLC, confirming SII to be significantly associated with survival. SII, which incorporates 3 hematological items, was also superior to NLR and PLR as a survival predictor, consistent with a prior study of esophageal cancer.…”
Section: Discussionsupporting
confidence: 74%
“…In addition, our study is novel in its incorporation of SII, a comprehensive hematological index based on the peripheral platelet, neutrophil, and lymphocyte counts, with prognostic significance. SII has already been demonstrated as a strong prognostic predictor in a variety of malignant tumors, [28][29][30][31] including NSCLC managed with chemoradiotherapy or surgery, [12][13][14][15] and our study is the first to date evaluating its predictive value in the setting of SABR for ES-NSCLC, confirming SII to be significantly associated with survival. SII, which incorporates 3 hematological items, was also superior to NLR and PLR as a survival predictor, consistent with a prior study of esophageal cancer.…”
Section: Discussionsupporting
confidence: 74%
“…Lymphocyte, neutrophil, and platelet counts were measured by complete blood count using automated hematology analyzing devices (Coulter ® DxH 800 analyzer) and presented as ×10 3 cells/ml. SII as an exposure variable was derived from platelet count × neutrophil count/lymphocyte count ( 11 , 13 , 34 ). CAP and LSM were designed as outcome variables to measure hepatic steatosis and liver fibrosis.…”
Section: Methodsmentioning
confidence: 99%
“…Recently, the systemic-immune-inflammation index (SII) based on neutrophils, lymphocytes and platelets as a jointed tool has been developed to offer prognostic information in patients with hepatocellular carcinoma, pancreatic cancer and germ-cell tumor [1618]. This novel integrated prognostic score combining peripheral neutrophils, lymphocytes and platelets is more powerful than individual cell type-based factors in prognostic assessment, presumably due to better reflect the balance of host inflammation and immune status [1921]. However, the prognostic value of these inflammatory and hematological markers in primary OSCC remains largely unexplored thus far.…”
Section: Introductionmentioning
confidence: 99%