Systemic immune inflammation index in patients with recurrent aphthous stomatitis

Atalay, Fatma; Kars, Ayhan; Topal, Kübra; Yavuz, Zeynep

doi:10.1016/j.bjorl.2022.02.007

Cited by 7 publications

(12 citation statements)

References 11 publications

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“…After conducting a database search and a manual search of the article citation list, we identified a total of 210 results. Eventually, we included 13 papers [ 16 – 28 ] in our systematic review and meta-analysis, after eliminating duplicates and irrelevant records. The detailed process of inclusion and exclusion is presented in Figure 1 , which shows the PRISMA flow diagram.…”

Section: Resultsmentioning

confidence: 99%

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Diagnostic Significance of Neutrophil to Lymphocyte Ratio in Recurrent Aphthous Stomatitis: A Systematic Review and Meta-Analysis

Rahimi,

Mirakhori,

Zelmanovich

et al. 2024

Dermatol Pract Concept

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Introduction: Recurrent aphthous stomatitis (RAS) is a prevalent ulcerative condition affecting oral mucosa. Objectives: A systematic review and meta-analysis was performed to compare the level of neutrophil to lymphocyte ratio (NLR) between individuals with RAS and those who are healthy. Methods: A systematic search for relevant publications before June 21, 2022, was conducted using Web of Science, PubMed, and Scopus. The results were presented as the standardized mean difference (SMD) with a 95% confidence interval (CI), and a random-effects model was used to calculate pooled effects due to the presence of significant heterogeneity. Quality assessment was performed using the Newcastle-Ottawa scale. Results: Overall, 13 article with were included in the analysis. NLR was higher among patients with RAS compared to healthy controls (SMD = 0.50, 95% CI = -0.20 to 0.79, P = 0.001, I2 = 91.5%). In the subgroup analysis based on the study design, it was found that retrospective studies showed higher levels of NLR in patients with RAS compared to healthy controls (SMD = 0.62, 95% CI= 0.16 to 1.08, P < 0.01), but these results were not applied to prospective studies (SMD = 0.35, 95% CI = -0.03 to 0.74, P < 0.07). Conclusion: Elevated neutrophil to lymphocyte ratio revealed crosstalk between systematic inflammation and RAS.

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Section: Resultsmentioning

confidence: 99%

“…In total, 13 articles, including 1239 patients with RAS and 1167 healthy controls, were included in the analysis [ 16 – 28 ]. Eleven of them were written in English [ 16 , 17 , 19 – 27 ], one in Arabic [ 28 ] and one in Turkish [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

Diagnostic Significance of Neutrophil to Lymphocyte Ratio in Recurrent Aphthous Stomatitis: A Systematic Review and Meta-Analysis

Rahimi,

Mirakhori,

Zelmanovich

et al. 2024

Dermatol Pract Concept

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“…However, some results contradict our findings, in which the WBC count 26 and platelet/lymphocyte ratio are higher than in controls. 27 This disparity could be attributed to differences in participant selection, sample size and the systemic inflammatory background, which needs to be investigated further.…”

Section: Discussionmentioning

confidence: 99%

Elevated serum fibrinogen levels in Chinese patients with minor recurrent aphthous stomatitis: An observational study

Yao,

Deng,

et al. 2023

Experimental Dermatology

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Fibrinogen is a protein that reflects systemic inflammation and regulates the immune response to disease. However, there is a scarcity of data on fibrinogen in recurrent aphthous stomatitis (RAS). We aimed to test the hypothesis that fibrinogen is involved in the aetiology of RAS. Between November 2016 and November 2018, we included 109 minor RAS patients and 29 age‐ and sex‐matched controls in a single‐center, observational study. Their clinical history and ulcer manifestations led to the diagnosis of minor RAS. The ulcer severity score (USS) was used to assess disease severity, and fibrinogen was also collected. We conducted three analyses: Analysis 1 (comparison of fibrinogen levels between patients and controls), Analysis 2 (comparison of fibrinogen levels between high and low USS patients) and Analysis 3 (comparison of fibrinogen levels between before and after anti‐inflammatory treatment in patients). The fibrinogen levels in the 109 minor RAS patients were statistically higher than in the 29 controls (mean [SD], 2.6 [0.5] vs. 2.3 [0.3]; Student's t‐test, p < 0.001). However, there were no significant differences in fibrinogen levels among the 43 patients with high USS and the 39 patients with low USS (mean [SD], 2.7 [0.5] vs. 2.6 [0.4]; Student's t‐test, p = 0.278). Furthermore, fibrinogen levels were significantly higher before anti‐inflammatory treatment in comparison to those after anti‐inflammatory treatment in the 35 paired patients (mean [SD], 2.6 [0.4] vs. 2.5 [0.4]; Student's t‐test, p = 0.026). Interestingly, fibrinogen levels were significantly higher in the 35 paired patients after anti‐inflammatory treatment compared to the 29 control subjects (mean [SD], 2.5 [0.4] vs. 2.3 [0.3]; Student's t‐test, p = 0.026]. Fibrinogen may play a role in the aetiology of RAS and may be a drug target for RAS treatment. Clinicians should be alert that high serum fibrinogen levels might be associated with the risk of RAS.

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“…Of seven studies, only two included inactive RAS patients, and only one of these reported a significant increase in NLR in inactive RAS patients compared with control subjects, with no differences in PLR and MPV between the groups [ 131 , 132 ]. When comparing active RAS patients and control subjects, four of six studies reported a significant increase in NLR in RAS [ [130] , [131] , [132] , 135 ]. In most studies that reported PLR and MPV, these indices did not differ between the two groups [ [130] , [131] , [132] , 133 , [134] , [135] ].…”

Section: Evidence For Involvement Of Neutrophils In the Pathogenesis ...mentioning

confidence: 99%

“…When comparing active RAS patients and control subjects, four of six studies reported a significant increase in NLR in RAS [ [130] , [131] , [132] , 135 ]. In most studies that reported PLR and MPV, these indices did not differ between the two groups [ [130] , [131] , [132] , 133 , [134] , [135] ]. Furthermore, only one of four studies reported an increase in the ANC in active RAS patients compared with controls, while one study reported a decrease (but not neutropenia) in ANC that was restored after remission [ 129 , 130 ].…”

Section: Evidence For Involvement Of Neutrophils In the Pathogenesis ...mentioning

confidence: 99%

Association of neutrophil defects with oral ulcers but undetermined role of neutrophils in recurrent aphthous stomatitis

Choi

2024

Heliyon

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Systemic immune inflammation index in patients with recurrent aphthous stomatitis

Cited by 7 publications

References 11 publications

Diagnostic Significance of Neutrophil to Lymphocyte Ratio in Recurrent Aphthous Stomatitis: A Systematic Review and Meta-Analysis

Diagnostic Significance of Neutrophil to Lymphocyte Ratio in Recurrent Aphthous Stomatitis: A Systematic Review and Meta-Analysis

Elevated serum fibrinogen levels in Chinese patients with minor recurrent aphthous stomatitis: An observational study

Association of neutrophil defects with oral ulcers but undetermined role of neutrophils in recurrent aphthous stomatitis

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