Systemic Immune-Inflammation Index Is a Prognostic Factor for Breast Cancer Patients After Curative Resection

Li, Wen; Ma, Guangzhi; Deng, Yunfu; Chen, Wenjie; Liu, Zhenkun; Chen, Fang; Wu, Qiang

doi:10.3389/fonc.2021.570208

Cited by 21 publications

(14 citation statements)

References 49 publications

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“…It was first described as an indicator of prognosis in patients with resected hepatocellular carcinoma [9]. Subsequently, SII was shown to have prognostic value for various cancers [15][16][17][18][19][20][21][22]. Previous studies in adult patients with sepsis are consistent with our results [23,24].…”

Section: Discussionsupporting

confidence: 90%

Association between admission systemic immune-inflammation index and mortality in critically ill patients with sepsis: a retrospective cohort study based on MIMIC-IV database

et al. 2023

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Systemic immune-inflammation index (SII) has been identified as a prognostic biomarker for various diseases. Our study aimed to investigate the association between SII and mortality risk in critically ill patients with sepsis, thus exploring possible tools for rapid screening. This retrospective cohort study was conducted using clinical data extracted from the Medical Information Mart for Intensive Care Database. The study included only patients diagnosed with sepsis admitted to the intensive care unit for the first time. We used the restricted cubic splines to explore the relationship between SII and 28-day mortality. Kaplan-Meier curve and Cox regression models were performed to evaluate the association between SII and mortality. Subgroup analysis was performed to explore the stability of the primary results. A total of 16,007 patients with sepsis were eligible in the final analysis. We found a J-shaped relationship between SII and mortality risk. The SII level associated with the lowest mortality risk was 774.46*10 9 /L. Compared with the reference group (second SII quartile), the 28-day mortality was increased in the highest quartile and third quartile groups of SII levels; fully adjusted HRs were 1.16 (1.02 to 1.32) and 1.40 (1.23 to 1.58), respectively. However, although the lower SII (Q1 group) also showed a trend toward a higher hazard of 28-day mortality, there was no statistical difference, with a fully adjusted HR of 1.05 (0.92 to 1.21). In the population of critically ill patients with sepsis, low and high SII levels were associated with an increased risk of short-term mortality. The 28-day mortality risk was lowest at SII levels of 774.46*10 9 /L.

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Section: Discussionsupporting

confidence: 90%

Association between admission systemic immune-inflammation index and mortality in critically ill patients with sepsis: a retrospective cohort study based on MIMIC-IV database

et al. 2023

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“…Therefore, SII should better reflect the inflammatory status compared to the three types of cells when assessed separately. Researchers have already described it as a prognostic marker in appendicitis [ 65 ], coronary artery disease [ 66 ] and neoplasms [ 67 , 68 ]. Patients with a high level of SII had a significantly higher mortality rate than those with a low SII [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

Neutrophil Counts, Neutrophil-to-Lymphocyte Ratio, and Systemic Inflammatory Response Index (SIRI) Predict Mortality after Off-Pump Coronary Artery Bypass Surgery

Urbanowicz

Michalak

Olasińska-Wiśniewska

et al. 2022

Cells

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Background: Several perioperative inflammatory markers are postulated to be significant factors for long-term survival after off-pump coronary artery bypass surgery (OPCAB). Hematological parameters, whether single or combined as indices, provide higher predictive values. Methods: The study group comprised 538 consecutive patients (125 (23%) females and 413 (77%) males) with a mean age of 65 +/− 9 years, who underwent OPCAB with a mean follow-up time of 4.7 +/− 1.7 years. This single-center retrospective analysis included perioperative inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR), systemic inflammatory response index (SIRI), aggregate index of systemic inflammation (AISI), and systemic inflammatory index (SII). Results: Multivariable analysis identified levels of neutrophils above 4.3 × 109/L (HR 13.44, 95% CI 1.05–3.68, p = 0.037), values of SIRI above 5.4 (HR 0.29, 95% CI 0.09–0.92, p = 0.036) and values of NLR above 3.5 (HR 2.21, 95% CI 1.48–3.32, p < 0.001) as being significant predictors of long-term mortality. The multifactorial models revealed the possibility of strong prediction by combining preoperative factors (COPD, stroke, PAD, and preoperative PLR) and postoperative neutrophil counts (p = 0.0136) or NLR (p = 0.0136) or SIRI (p = 0.0136). Conclusions: Among the postoperative inflammatory indices, the levels of neutrophils, NLR, and SIRI are the most prominent markers for long-term survival after off-pump coronary artery bypass surgery, when combined with preoperative characteristics.

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“…NLR had been reported to correlate with survival outcome in many cancers, including breast cancer, [12] colorectal cancer, [13] prostate cancer, [14] renal cell carcinoma, [8] and gliomas. [9] SII, a novel inflammatory biomarker calculated by the following formula: platelet count × neutrophil count/lymphocyte count, has been reported to be associated with worse survival in many patients with malignant tumors, including breast cancer, [15] hepatocellular carcinoma [16] and glioma. [17] A recent study reported that a higher SII predicted a worse outcome in glioblastoma patients.…”

Section: Introductionmentioning

confidence: 99%

Association between systemic immune-inflammation index (SII) and survival outcome in patients with primary glioblastoma

Yang

Wang

2023

Medicine

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The purpose was to evaluate the prognostic value of systemic immune-inflammation index (SII) in glioblastoma patients. A total of 100 patients were retrospectively analyzed. We performed Kaplan-Meier and Cox regression analyses to determine the prognostic significance of SII. A nomogram was constructed by incorporating independent prognostic variables. The predictive accuracies of nomograms were evaluated by Harrell concordance index (c-index) and receiver operating characteristic curve analysis; the clinical benefit was evaluated by decision curve analysis. A high SII (>510.8 × 10 9 cells/L) (hazard ratio = 1.672, P = .034) and neutrophil count (>3.9 × 10 9 cells/L) (hazard ratio = 1.923, P = .009) were independently related with poor outcome in glioblastoma patients based on Cox analysis. The nomogram incorporating SII showed a good predictive accuracy (c-index = 0.866). Preoperative SII and neutrophil count are potential prognostic biomarkers for overall survival in glioblastoma patients and the nomogram model that integrated the SII may be used to facilitate a comprehensive preoperative survival evaluation.

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Systemic Immune-Inflammation Index Is a Prognostic Factor for Breast Cancer Patients After Curative Resection

Cited by 21 publications

References 49 publications

Association between admission systemic immune-inflammation index and mortality in critically ill patients with sepsis: a retrospective cohort study based on MIMIC-IV database

Association between admission systemic immune-inflammation index and mortality in critically ill patients with sepsis: a retrospective cohort study based on MIMIC-IV database

Neutrophil Counts, Neutrophil-to-Lymphocyte Ratio, and Systemic Inflammatory Response Index (SIRI) Predict Mortality after Off-Pump Coronary Artery Bypass Surgery

Association between systemic immune-inflammation index (SII) and survival outcome in patients with primary glioblastoma

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