Systemic Immune-Inflammation Index Is A Novel Marker to Predict Functionally Significant Coronary Artery Stenosis

Erdoğan, Mehmet; Erdöl, Mehmet Akif; Öztürk, Selçuk; Durmaz, Tahir

doi:10.2217/bmm-2020-0274

Cited by 91 publications

(102 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…SII was found to be better than NLR and PLR as a prognostic marker in esophageal squamous cell carcinoma patients 23,24 . Likewise, we recently found that SII predicts hemodynamically significant CAD better than NLR and PLR 16 . Due to pathophysiological similarities between CAD and calcific AS described above, we hypothesized that SII levels may be increased and predict severe AS, and we found that SII levels both as a continuous and categorical variable independently predict calcific severe AS.…”

Section: Discussionmentioning

confidence: 57%

The relationship between calcific severe aortic stenosis and systemic immune‐inflammation index

et al. 2021

Self Cite

View full text Add to dashboard Cite

Aim Calcific aortic stenosis (AS) is a common valvular disease especially in elderly population. Inflammation plays significant role in the pathophysiological mechanism. Systemic immune‐inflammation index (SII) is a novel marker of immune system and inflammation that includes neutrophil, lymphocyte, and platelet cell counts. The aim of this study was to investigate the predictive value of SII in calcific severe AS. Materials and Methods Severe calcific AS patients were categorized into two groups: High flow‐high gradient (HFHG) AS (n = 289) and low flow‐low gradient AS (n = 79). Control group included 273 patients with similar clinical and demographic characteristics but without AS. SII was calculated as absolute platelet count × absolute neutrophil count/absolute lymphocyte count. Results SII levels were 525 ± 188, 835 ± 402, and 784 ± 348 in control, HFHG AS, and LFLG AS groups, respectively (P < .001). Correlation analyses revealed significant and positive correlation between SII and mean aortic transvalvular pressure gradient (r = .342, P < .001), and negative and significant correlation between SII and AVA (r = −.461, P < .001). Multivariate analysis performed in separate models demonstrated sex, CAD, LDL, and SII levels (Odds ratio [OR]: 1.004, 95 CI%:1.003–1.004) as independent predictors of severe AS in Model 1. According to Model 2, sex, CAD, LDL, and high SII (>661) (OR:5.78, 95 CI%:3.93–4.89) remained as independent predictors of severe AS. Conclusion SII levels can be useful to predict severe calcific AS patients and significantly correlate with AVA and mean aortic transvalvular pressure gradient.

show abstract

Section: Discussionmentioning

confidence: 57%

The relationship between calcific severe aortic stenosis and systemic immune‐inflammation index

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…The systemic immune-inflammatory (SII) index is an integrated marker of systemic inflammation and it results from a combination of NLR and PLR. The SII index has been already extensively assessed as a marker of prognosis and mortality of patients with solid tumors or coronary artery disease [ 41 , 42 , 43 ]. Until now, very limited data is available concerning the relationship between SII index and psychiatric disorders.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio, a Novel Inflammatory Marker, as a Predictor of Bipolar Type in Depressed Patients: A Quest for Biological Markers

Dionisie

Filip

Manea

et al. 2021

JCM

View full text Add to dashboard Cite

(1) Background: Recent research suggests inflammation as a factor involved in the pathophysiology of mood disorders. Neutrophil-to-lymphocyte (NLR), monocyte-to-lymphocyte (MLR), platelet-to-lymphocyte (PLR), and systemic immune-inflammatory (SII) index ratios have been studied as peripheral markers of inflammation in bipolar and major depressive disorders. The purpose of this study is to comparatively analyze these inflammatory ratios among manic episodes of bipolar disorder, bipolar depression and unipolar depression. (2) Methods: 182 patients were retrospectively included in the study and divided into three groups: 65 manic patients, 34 patients with bipolar depression, and 83 unipolar depressive patients. White blood cells, neutrophils, monocytes, lymphocytes, and platelets were retrieved from the patients’ database. NLR, MLR, PLR, and SII index were calculated using these parameters. (3) Results: Patients with manic episodes had elevated NLR (p < 0.001), MLR (p < 0.01), PLR (p < 0.05), and SII index (p < 0.001) compared to unipolar depression and increased NLR (p < 0.05) and SII index (p < 0.05) when compared to bipolar depression. NLR (p < 0.01) and SII index (p < 0.05) were higher in the bipolar depression than unipolar depression. NLR is an independent predictor of the bipolar type of depression in depressive patients. (4) Conclusions: The results confirm the role of inflammation in the pathophysiology of mood disorders and suggest the ability of NLR as a marker for the differentiation of bipolar from unipolar depression.

show abstract

“…[15] Post hoc analysis variable de nitions For this post hoc analysis, the in ammatory indexes were determined based on values of monocytes (M), neutrophils (N), lymphocytes (L), and/or platelets (P) in patients received surgical ablation at indicated data: SII de ned as P×N/L, NLR de ned as N/L, platelet-lymphocyte ratio (PLR) de ned as P/L, lymphocyte to monocyte ratio (LMR) de ned as L/M, monocytes-NLR (MNLR) de ned as M×N/L, monocytes-PLR (MPLR) de ned as M×P/L . [14,16,17]…”

Section: Patients' Selectionmentioning

confidence: 99%

“…[13] Systemic immune-in ammation index (SII) is a novel marker that brings together these three in ammatory peripheral cell counts and predict functionally signi cant coronary artery stenosis. [14] In this study, we investigated the association of perioperative systemic in ammation index, and changes during treatment, with outcomes in AF patients treated with CryoMaze concomitant with mitral valve surgery.…”

Section: Introductionmentioning

confidence: 99%

The Systemic-Immune-Inflammation Index Predicts the Recurrence of Atrial Fibrillation After Cryomaze Concomitant With Mitral Valve Surgery

Zhang

Liu

et al. 2021

Preprint

View full text Add to dashboard Cite

Background and aims: Inflammation plays a key role in the initiation and progression of atrial fibrillation (AF). The systemic inflammation indexes are easily evaluated and predict AF development. However, it’s role in prediction of recurrence of AF is unknown. We aim to explore the association between the systemic inflammation indexes and recurrence of AF in patients underwent cryoablation (CryoMaze) concomitant with mitral valve surgery. Methods We examined systemic inflammation indexes during perioperative period in 122 patients between 2015 to 2018. Systemic inflammation indexes were developed by systemic immune-inflammation index (SII), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocytes to monocytes ratio (LMR). Univariate and multivariate analyses were performed to examine the association of each markers with recurrence of AF. Results Of the 122 patients included in this study, 22 patients (18%) experienced AF recurrence after CryoMaze concomitant with mitral valve surgery. There is no significant difference between each systemic inflammation indexes before surgery and recurrence of AF. In univariate analysis, MLR after surgery 3 days, PLR, MPLR, NLR, SII after surgery 7 days were able to predict recurrence of AF. In multivariate analyses, SII ≥ 1696 independently predicted recurrence (OR, 3.719; 95% CI, 1.417–9.760). Interestingly, baseline SII showed no significant in prediction of recurrence. It was sharply elevated after surgery and dropped slowly. In patients of recurrence, SII after 7days of surgery increased again. Conclusions The raised SII again was associated with an increased risk of the postoperative recurrence of AF and independently predicted the late recurrence of AF after CryoMaze concomitant with mitral valve surgery.

show abstract

Systemic Immune-Inflammation Index Is A Novel Marker to Predict Functionally Significant Coronary Artery Stenosis

Cited by 91 publications

References 24 publications

The relationship between calcific severe aortic stenosis and systemic immune‐inflammation index

The relationship between calcific severe aortic stenosis and systemic immune‐inflammation index

Neutrophil-to-Lymphocyte Ratio, a Novel Inflammatory Marker, as a Predictor of Bipolar Type in Depressed Patients: A Quest for Biological Markers

The Systemic-Immune-Inflammation Index Predicts the Recurrence of Atrial Fibrillation After Cryomaze Concomitant With Mitral Valve Surgery

Contact Info

Product

Resources

About