Systemic Immune Inflammatory Index of Patients With Idiopathic Sudden Sensorineural Hearing Loss: Comparison of NLR and PRL Values

Ulu, Şahin; Kınar, Abdullah; Bucak, Abdulkadir; Özdemir, Murat

doi:10.1177/0145561320924312

Cited by 6 publications

(6 citation statements)

References 22 publications

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“…Therefore, they concluded that NLR was a reliable predictor for the prognosis of SSNHL. Similar results have also been reported by Ulu et al 39 , Qiao et al 40 and Masuda et al 41 . They found that the NLR and PLR of the case group were higher than those of the control group.…”

Section: Discussionsupporting

confidence: 90%

Etiological analysis of patients with sudden sensorineural hearing loss: a prospective case–control study

Xie

Karpeta

Tong

et al. 2023

Sci Rep

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Sudden sensorineural hearing loss (SSNHL) is a multifactorial emergency disease. Until now, the etiology of SSNHL is still unknown. Previous studies regarding the etiology of SSNHL are clinical studies depending on clinical data collection and analysis. Due to the insufficient sample size or various selective bias in clinical studies, the results of these studies may be inaccurate. This prospective case–control study aimed at exploring the possible etiology and risk factors of SSNHL. We enrolled 255 SSNHL patients and 255 sex-, age- and residence-matched non-SSNHL subjects in the control group. Our study shows that there was no significant difference in the prevalence of comorbidities including hypertension and diabetes, as well as the incidence of smoking and drinking habits between the case and control groups (P > 0.05). In addition, the peripheral blood white blood cell count, neutrophil count, platelet-to-lymphocyte ratio (PLR) and fibrinogen level of the case group were significantly higher than those in the control group (P < 0.05). These findings suggest smoking, drinking, hypertension and diabetes may not be related to the onset of SSNHL. However, hypercoagulable state and inner ear vascular microthrombosis related to an elevated fibrinogen level might be the risk factors of the disease. In addition, inflammation play an important role of SSNHL onset.Trial Registration: Chinese Clinical Trial Registry. Registration number: ChiCTR2100048991.

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Section: Discussionsupporting

confidence: 90%

Etiological analysis of patients with sudden sensorineural hearing loss: a prospective case–control study

Xie

Karpeta

Tong

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Therefore, they concluded that NLR was a reliable predictor for the prognosis of SSNHL. Similar results have also been reported by Ulu et al 37 ,Qiao et al 38 and Masuda et al 39 . They found that the NLR and PLR of the case group were higher than those of the control group.…”

Section: Discussionsupporting

confidence: 90%

Etiological analysis of patients with sudden sensorineural hearing loss: a prospective case-control study

Xie

Karpeta

Tong

et al. 2023

Preprint

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Sudden sensorineural hearing loss (SSNHL) is a multifactorial emergency disease. Until now, the etiology of SSNHL is still unknown. Previous studies regarding the etiology of SSNHL are clinical studies depending on clinical data collection and analysis. Due to the insufficient sample size or various selective bias in clinical studies, the results of these studies may be inaccurate. This prospective case-control study aimed at exploring the possible etiology and risk factors of SSNHL. We enrolled 255 SSNHL patients and 255 sex-, age- and residence- matched non-SSNHL subjects in the control group. Our study shows that there was no significant difference in the prevalence of comorbidities including hypertension and diabetes, as well as the incidence of smoking and drinking habits between the case and control groups (P > 0.05). In addition, the peripheral blood white blood cell count, neutrophil count, platelet-to-lymphocyte ratio (PLR) and fibrinogen level of the case group were significantly higher than those in the control group (P < 0.05). These findings suggest smoking, drinking, hypertension and diabetes may not be related to the onset of SSNHL. However, hypercoagulable state and inner ear vascular microthrombosis related to an elevated fibrinogen level might be the risk factors of the disease. In addition, inflammation play an important role of SSNHL onset. Trial Registration Chinese Clinical Trial Registry. Registration number: ChiCTR2100048991

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“…41 Lymphocytes are consistently lower in sudden SNHL than controls and are lower still in cases of sudden SNHL that do not recover. 27 Raised neutrophils correlate with severe hearing loss and poor prognosis. 42 Across numerous studies, these trends indicate inflammatory or autoimmune aetiology.…”

Section: Discussionmentioning

confidence: 99%

“…26 The Systemic Immune Inflammation Index (platelets × neutrophils/lymphocytes) gives an indication of systemic inflammation and is associated with poor recovery. 27…”

Section: Plateletsmentioning

confidence: 99%

Blood tests as biomarkers for the diagnosis and prognosis of sudden sensorineural hearing loss in adults: a systematic review

Al-Azzawi

Stapleton

2023

J. Laryngol. Otol.

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Objective Sudden sensorineural hearing loss is considered idiopathic in up to 90 per cent of cases. This study explored the role of blood tests as biomarkers for the diagnosis and prognosis of sudden sensorineural hearing loss. Method Two researchers filtered 34 papers into the final review. This review was pre-registered on the Prospero database and conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. Results Raised inflammatory markers are almost universal in sudden sensorineural hearing loss, suggesting an inflammatory or autoimmune process. The most useful biomarkers are neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and fibrinogen level. Focused investigations should be deployed on a case-by-case basis to identify underlying metabolic, infective and autoimmune conditions. Conclusion A full blood count and coagulation screen (fibrinogen) is recommended in all cases of sudden sensorineural hearing loss. These are inexpensive, accessible and offer as much diagnostic and prognostic information as any other biomarker. There is emerging evidence regarding specific biomarkers for sudden sensorineural hearing loss prognosis, with heat shock protein-70, anti-endothelial cell antibody and prestin demonstrating potential; investigation of their validity through prospective, controlled research is recommended.

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Systemic Immune Inflammatory Index of Patients With Idiopathic Sudden Sensorineural Hearing Loss: Comparison of NLR and PRL Values

Cited by 6 publications

References 22 publications

Etiological analysis of patients with sudden sensorineural hearing loss: a prospective case–control study

Etiological analysis of patients with sudden sensorineural hearing loss: a prospective case–control study

Etiological analysis of patients with sudden sensorineural hearing loss: a prospective case-control study

Blood tests as biomarkers for the diagnosis and prognosis of sudden sensorineural hearing loss in adults: a systematic review

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