Systemic immunological perturbations and placental pathology in preeclampsia

Jarmund, Anders Hagen; Giskeødegård, Guro F.; Rakner, Johanne Johnsen; Stokkeland, Live Marie Tobiesen; Ryssdal, Mariell; Steinkjer, Bjørg; Løvvik, Tone Shetelig; Stafne, Signe Nilssen; Bjørge, Line; Iversen, Ann‐Charlotte

doi:10.1016/j.placenta.2021.07.061

Cited by 3 publications

(3 citation statements)

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“…Since studies indicate the role of TNF receptors as possible blockers of TNF cytokine action (40), the higher receptor level might be related to the limited immune response. As shown in a prior study (41), even a lower level of chemokine eotaxin-2 in infected individuals might also be associated with a milder immune response. Compared to those in systemic immunity, cytokines in follicular fluid act directly on oocytes which is likely more important for modulating the The findings of our study indicated that mild or asymptomatic SARS-CoV-2 infection during COS did not have a detrimental impact on ART outcomes.…”

Section: Discussionsupporting

confidence: 56%

The impact and inflammatory characteristics of SARS-CoV-2 infection during ovarian stimulation on the outcomes of assisted reproductive treatment

Hu,

Feng,

Chen

et al. 2024

Front. Endocrinol.

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IntroductionDespite the global prevalence of coronavirus disease 2019 (COVID-19), limited research has been conducted on the effects of SARS-CoV-2 infection on human reproduction. The aims of this study were to investigate the impact of SARS-CoV-2 infection during controlled ovarian stimulation (COS) on the outcomes of assisted reproductive treatment (ART) and the cytokine status of patients.MethodsThis retrospective cohort study included 202 couples who received ART treatment, 101 couples infected with SARS-CoV-2 during COS and 101 matched uninfected couples. The parameters of ovarian stimulation and pregnancy outcomes were compared between the two groups. The All-Human Inflammation Array Q3 kit was utilized to measure cytokine levels in both blood and follicular fluid.ResultsNo difference was found in the number of good-quality embryos (3.3 ± 3.1 vs. 3.0 ± 2.2, P = 0.553) between the infected and uninfected groups. Among couples who received fresh embryo transfers, no difference was observed in clinical pregnancy rate (53.3% vs. 51.5%, P = 0.907). The rates of fertilization, implantation, miscarriage, ectopic pregnancy and live birth were also comparable between the two groups. After adjustments were made for confounders, regression models indicated that the quality of embryos (B = 0.16, P = 0.605) and clinical pregnancy rate (P = 0.206) remained unaffected by SARS-CoV-2 infection. The serum levels of MCP-1, TIMP-1, I-309, TNF-RI and TNF-RII were increased, while that of eotaxin-2 was decreased in COVID-19 patients. No significant difference was found in the levels of cytokines in follicular fluid between the two groups.ConclusionAsymptomatic or mild COVID-19 during COS had no adverse effects on ART outcomes. Although mild inflammation was present in the serum, it was not detected in the follicular fluid of these patients. The subsequent immune response needs further investigation.

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Section: Discussionsupporting

confidence: 56%

The impact and inflammatory characteristics of SARS-CoV-2 infection during ovarian stimulation on the outcomes of assisted reproductive treatment

Hu,

Feng,

Chen

et al. 2024

Front. Endocrinol.

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“…Immunoassay is a high-throughput technology in which the results can be influenced by, and need correction for, batch effects to avoid conclusions based on random external events (43). Therefore, the samples were adjusted using fluorescent intensity (FI) values from the serum controls before the concentrations were estimated from standard curves, as previously described (33). The measured values were individually corrected for each cytokine.…”

Section: Data Preprocessingmentioning

confidence: 99%

New immune phenotypes for treatment response in high-grade serous ovarian carcinoma patients

Torkildsen,

Austdal,

Jarmund

et al. 2024

Front. Immunol.

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Despite advances in surgical and therapeutic approaches, high-grade serous ovarian carcinoma (HGSOC) prognosis remains poor. Surgery is an indispensable component of therapeutic protocols, as removal of all visible tumor lesions (cytoreduction) profoundly improves the overall survival. Enhanced predictive tools for assessing cytoreduction are essential to optimize therapeutic precision. Patients’ immune status broadly reflects the tumor cell biological behavior and the patient responses to disease and treatment. Serum cytokine profiling is a sensitive measure of immune adaption and deviation, yet its integration into treatment paradigms is underexplored. This study is part of the IMPACT trial (NCT03378297) and aimed to characterize immune responses before and during primary treatment for HGSOC to identify biomarkers for treatment selection and prognosis. Longitudinal serum samples from 22 patients were collected from diagnosis until response evaluation. Patients underwent primary cytoreductive surgery or neoadjuvant chemotherapy (NACT) based on laparoscopy scoring. Twenty-seven serum cytokines analyzed by Bio-Plex 200, revealed two immune phenotypes at diagnosis: Immune High with marked higher serum cytokine levels than Immune Low. The immune phenotypes reflected the laparoscopy scoring and allocation to surgical treatment. The five Immune High patients undergoing primary cytoreductive surgery exhibited immune mobilization and extended progression-free survival, compared to the Immune Low patients undergoing the same treatment. Both laparoscopy and cytoreductive surgery induced substantial and transient changes in serum cytokines, with upregulation of the inflammatory cytokine IL-6 and downregulation of the multifunctional cytokines IP-10, Eotaxin, IL-4, and IL-7. Over the study period, cytokine levels uniformly decreased in all patients, leading to the elimination of the initial immune phenotypes regardless of treatment choice. This study reveals distinct pre-treatment immune phenotypes in HGSOC patients that might be informative for treatment stratification and prognosis. This potential novel biomarker holds promise as a foundation for improved assessment of treatment responses in patients with HGSOC. ClinicalTrials.gov Identifier: NCT03378297.

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Section: Data Preprocessingmentioning

confidence: 99%

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Systemic immunological perturbations and placental pathology in preeclampsia

Cited by 3 publications

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The impact and inflammatory characteristics of SARS-CoV-2 infection during ovarian stimulation on the outcomes of assisted reproductive treatment

The impact and inflammatory characteristics of SARS-CoV-2 infection during ovarian stimulation on the outcomes of assisted reproductive treatment

New immune phenotypes for treatment response in high-grade serous ovarian carcinoma patients

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