Systemic infection of SARS-CoV-2 in free ranging Leopard (<i>Panthera pardus fusca</i>) in India

Mahajan, Sumit; Karikalan, M.; Chander, Vikas; Pawde, A. M.; Saikumar, G.; Semmaran, M; Lakshmi, P Sree; Sharma, Megha; Nandi, Sukdeb; Gupta, Vivek Kumar; Singh, Raj Kumar; Sharma, Gaurav Kumar

doi:10.1101/2022.01.11.475327

Cited by 9 publications

(7 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4). This might turn into a reduced ability to adapt to any rapid environmental change or the emergence of new diseases such as SARS-CoV-2 in leopards (Mahajan et al, 2022;Ralls et al, 2020). More than 50% of their genome is under RoH (Fig.…”

Section: Discussionmentioning

confidence: 99%

Genomics reveals introgression and purging of deleterious mutations in the Arabian leopard (Panthera pardus nimr)

Riaño

Fontsere

Manuel

et al. 2022

Preprint

View full text Add to dashboard Cite

Low genetic variation and high levels of inbreeding are usually a consequence of recent population declines in endangered species. From a conservation point of view, it is essential to genetically screen endangered populations to help assess their vulnerability to extinction and to properly create informed management actions towards their conservation efforts. The leopard, Panthera pardus, is a highly generalist predator with currently eight different subspecies inhabiting a wide range of habitats. Yet, genomic data is still lacking for the Critically Endangered Arabian leopard (P. p. nimr). Here, we sequenced the whole genome of two specimens of Arabian leopard and assembled the most complete genomic dataset for leopards to date, including genomic data for all current subspecies. Our phylogenomic analyses show that leopards are divided into two deeply divergent clades, one including the only African subspecies and a second one including all seven subspecies of Asian leopards. Interestingly, the Arabian leopard represents a well-differentiated lineage sister to the rest of Asian subspecies. The demographic history, genomic diversity, Runs of Homozygosity (RoHs), and mutational load in the Arabian leopard indicate a prolonged population decline, which has led to an increase in inbreeding and RoHs, with consequent purging of deleterious mutations. Our study represents the first attempt to genetically inform captive breeding programs for this Critically Endangered subspecies. Still, more genomes, particularly from wild individuals, are needed to fully characterise the genetic makeup of this singular and iconic subspecies.

show abstract

Section: Discussionmentioning

confidence: 99%

Genomics reveals introgression and purging of deleterious mutations in the Arabian leopard (Panthera pardus nimr)

Riaño

Fontsere

Manuel

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…14 Whole-genome sequence analysis confirmed that the Indian leopard had been infected with the SARS-CoV-2 δ variant, possibly from humans. 14…”

Section: Snow Leopard and Indian Leopardmentioning

confidence: 90%

“…The leopards were suspected to have been infected by asymptomatic staff 12,13 . A wild Indian leopard ( Panthera pardus fusca ) infected with SARS‐CoV‐2 was found dead in India 14 . Whole‐genome sequence analysis confirmed that the Indian leopard had been infected with the SARS‐CoV‐2 δ variant, possibly from humans 14 …”

Section: Natural Infections In Animalsmentioning

confidence: 99%

SARS‐CoV‐2 and natural infection in animals

Qiu

Liu

Sha

2022

Journal of Medical Virology

View full text Add to dashboard Cite

Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) is the causative agent of the novel coronavirus disease (COVID‐19) pandemic, which has caused serious challenges for public health systems worldwide. Due to the close relationship between animals and humans, confirmed transmission from humans to numerous animal species has been reported. Understanding the cross‐species transmission of SARS‐CoV‐2 and the infection and transmission dynamics of SARS‐CoV‐2 in different animals is crucial to control COVID‐19 and protect animal health. In this review, the possible animal origins of SARS‐CoV‐2 and animal species naturally susceptible to SARS‐CoV‐2 infection are discussed. Furthermore, this review categorizes the SARS‐CoV‐2 susceptible animals by families, so as to better understand the relationship between SARS‐CoV‐2 and animals.

show abstract

“…mink [15][16][17] ; and free-ranging wildlife 11 , e.g. white-tailed deer [18][19][20] and leopard 21 . SARS-CoV-2-infected animals may experience subclinical to severe signs of infection 3,14,17 and implemented interventions range from individual treatment to preventive culling.…”

Section: Background and Summarymentioning

confidence: 99%

SARS-ANI: A Global Open Access Dataset of Reported SARS-CoV-2 Events in Animals

Nerpel

Yang

Sorger

et al. 2022

Preprint

View full text Add to dashboard Cite

The zoonotic origin of SARS-CoV-2, the etiological agent of COVID-19, is not yet fully resolved. Although natural infections in animals are reported in a wide range of species, large knowledge and data gaps remain regarding SARS-CoV-2 animal hosts. We used two major health databases to extract unstructured data and generated a comprehensive global dataset of thoroughly documented SARS-CoV-2 events in animals. The dataset integrates relevant epidemiological and clinical data on each event and is readily usable for analytical purposes. We also share the code for technical and visual validation of the data and created a user-friendly dashboard for data exploration. Data on SARS-CoV-2 occurrence in animals is critical to adapt monitoring strategy, prevent the formation of animal reservoirs, and tailor future human and animal vaccination programs. The FAIRness and analytical flexibility of the data will support research efforts on SARS-CoV-2 at the human-animal-environment interface. We intend to update this dataset weekly for at least one year and, through collaborative processes, to develop the dataset further and expand its use.

show abstract

Systemic infection of SARS-CoV-2 in free ranging Leopard (Panthera pardus fusca) in India

Cited by 9 publications

References 13 publications

Genomics reveals introgression and purging of deleterious mutations in the Arabian leopard (Panthera pardus nimr)

Genomics reveals introgression and purging of deleterious mutations in the Arabian leopard (Panthera pardus nimr)

SARS‐CoV‐2 and natural infection in animals

SARS-ANI: A Global Open Access Dataset of Reported SARS-CoV-2 Events in Animals

Contact Info

Product

Resources

About