Systemic infection with Candida albicans in breast tumor bearing mice: Cytokines dysregulation and induction of regulatory T cells

Ahmadi, Nahid; Ahmadi, Abbas; Kheirali, E.; Yadegari, Mohammad Hossein; Bayat, Mansour; Shajiei, Arezoo; Amini, Abbas; Ashrafi, Somayeh; Abolhassani, Mohsen; Faezi, Sobhan; Yazdanparast, Seyed Amir; Mahdavi, Mehdi

doi:10.1016/j.mycmed.2018.10.006

Cited by 16 publications

(13 citation statements)

References 27 publications

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“…The downside of these regulatory cells has been studied in different scientific reports, in which both an immune activity suppression against C . albicans and a greater predisposition to candidemia have been demonstrated [46,47].…”

Section: Discussionmentioning

confidence: 99%

The Overlooked Immune State in Candidemia: A Risk Factor for Mortality

Ortega-Loubón

Cano-Hernández²,

Poves-Álvarez³

et al. 2019

JCM

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Lymphopenia has been related to increased mortality in septic patients. Nonetheless, the impact of lymphocyte count on candidemia mortality and prognosis has not been addressed. We conducted a retrospective study, including all admitted patients with candidemia from 2007 to 2016. We examined lymphocyte counts during the first 5 days following the diagnosis of candidemia. Multivariable logistic regression analysis was performed to determine the relationship between lymphocyte count and mortality. Classification and Regression Tree analysis was used to identify the best cut-off of lymphocyte count for mortality associated with candidemia. From 296 cases of candidemia, 115 died, (39.8% 30-day mortality). Low lymphocyte count was related to mortality and poor outcome (p < 0.001). Lymphocyte counts < 0.703 × 109 cells/L at diagnosis (area under the curve (AUC)-ROC, 0.783 ± 0.042; 95% confidence interval (CI), 0.700–0.867, p < 0.001), and lymphocyte count < 1.272 × 109 cells/L five days later (AUC-ROC, 0.791 ± 0.038; 95%CI, 0.716–0.866, p < 0.001) increased the odds of mortality five-fold (odds ratio (OR), 5.01; 95%CI, 2.39–10.93) at time of diagnosis, and three-fold (OR, 3.27; 95%CI, 1.24–8.62) by day 5, respectively. Low lymphocyte count is an independent predictor of mortality in patients with candidemia and might serve as a biomarker for predicting candidemia-associated mortality and poor outcome.

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Section: Discussionmentioning

confidence: 99%

The Overlooked Immune State in Candidemia: A Risk Factor for Mortality

Ortega-Loubón

Cano-Hernández²,

Poves-Álvarez³

et al. 2019

JCM

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“…For example, systemic infection with Candida albicans (candidiasis) in tumor-bearing mice does not significantly increase the percentage of Tregs compared to the tumor group, but it significantly increases the proportion of Tregs in the spleen of the non-tumor bearing mouse. Surprisingly, systemic infection with C. albicans promotes the rapid growth of tumors, and the percentage of tumor-infiltrated Tregs in the tumor/candidiasis group is significantly higher than these in the tumor only group (64). This demonstrates that candidiasis could promote the growth of tumors by expanding Tregs: tumors and candidiasis promote each other through increased Treg activity.…”

Section: Host-dependent Treg Patterns In Sepsismentioning

confidence: 89%

“…Patients with malignancies and immunodeficiencies are more likely to develop Candida albicans infection that leads to candidiasis (171). C. albicans induces the production of tumor infiltrating and IL-10 producing Tregs through toll-like receptor (TLR) 2, which leads to immune escape (64,172). Different degrees (such as 1,3-b-D-glucan -positive colonization and invasive candidiasis) of Candida have different effects on patients with abdominal sepsis.…”

Section: Pathogen-specific Treg Patterns In Sepsismentioning

confidence: 99%

Regulatory T Cells: Angels or Demons in the Pathophysiology of Sepsis?

et al. 2022

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Sepsis is a syndrome characterized by life-threatening organ dysfunction caused by the dysregulated host response to an infection. Sepsis, especially septic shock and multiple organ dysfunction is a medical emergency associated with high morbidity, high mortality, and prolonged after-effects. Over the past 20 years, regulatory T cells (Tregs) have been a key topic of focus in all stages of sepsis research. Tregs play a controversial role in sepsis based on their heterogeneous characteristics, complex organ/tissue-specific patterns in the host, the multi-dimensional heterogeneous syndrome of sepsis, the different types of pathogenic microbiology, and even different types of laboratory research models and clinical research methods. In the context of sepsis, Tregs may be considered both angels and demons. We propose that the symptoms and signs of sepsis can be attenuated by regulating Tregs. This review summarizes the controversial roles and Treg checkpoints in sepsis.

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“…Both EEP and DTX diminished the candidacidal activity of monocytes whilst the combination EEP + DTX exerted an immunorestorative action. This is a positive result, since C. albicans escape mechanisms may contribute to breast tumor growth in mice by inducing IL-10 production by the host and reducing IFN-γ production, consequently inhibiting the Th1 response that is effective against infections and tumor development (Ahmadi et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Brazilian green propolis: A novel tool to improve the cytotoxic and immunomodulatory action of docetaxel on MCF‐7 breast cancer cells and on women monocyte

Cardoso

Santiago

Conti

et al. 2021

Phytotherapy Research

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Docetaxel (DTX) is used against breast cancer despite its side effects such as toxicity and immunosuppression. Here we investigated the cytotoxic and immunomodulatory effects of the ethanol solution extract of propolis (EEP) in combination with DTX on MCF‐7 breast cancer cells and on women's monocyte. The cytotoxic potential of EEP + DTX was assessed by MTT assay and the type of tumor cell death was evaluated by flow cytometry. The effects of EEP + DTX on the migration and invasion of MCF‐7 cells were analyzed. Cytokine production by monocytes was assessed by ELISA and the expression of cell surface markers was evaluated by flow cytometry. We also assessed the fungicidal activity of monocytes against Candida albicans and the generation of reactive oxygen species (ROS). Finally, the impact of the supernatants of treated monocytes in the viability, migration, and invasiveness of tumor cells was assessed. EEP enhanced the cytotoxicity of DTX alone against MCF‐7 cells by inducing necrosis and inhibiting their migratory ability. EEP + DTX exerted no cytotoxic effects on monocytes and stimulated HLA‐DR expression, TNF‐α, and IL‐6 production, exerted an immunorestorative action in the fungicidal activity, and reduced the oxidative stress. Our findings have practical implications and reveal new insights for complementary medicine.

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Systemic infection with Candida albicans in breast tumor bearing mice: Cytokines dysregulation and induction of regulatory T cells

Cited by 16 publications

References 27 publications

The Overlooked Immune State in Candidemia: A Risk Factor for Mortality

The Overlooked Immune State in Candidemia: A Risk Factor for Mortality

Regulatory T Cells: Angels or Demons in the Pathophysiology of Sepsis?

Brazilian green propolis: A novel tool to improve the cytotoxic and immunomodulatory action of docetaxel on MCF‐7 breast cancer cells and on women monocyte

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