Systemic inflammation markers and the prevalence of hypertension: A NHANES cross-sectional study

Xu, Junpeng; Zeng, Rui‐Xiang; Zhang, Yu-Zhuo; Lin, Shanshan; Tan, Jia-Wei; Zhu, Hai-Yue; Mai, Xiao-Yi; Guo, Liheng; Zhang, Minzhou

doi:10.1038/s41440-023-01195-0

Cited by 63 publications

(48 citation statements)

References 38 publications

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“…Moreover, a recent cross-sectional study based on NHANES data from 1999-2010 reveals that the association of SII and NLR with adult HTN is stronger in older populations [35]. Interestingly, the strikingly signi cant correlation between systemic in ammatory markers and HBP was observed in younger children in this study.…”

Section: Discussionsupporting

confidence: 46%

“…It's worth noting that SII is a novel in ammatory biomarker based on three immune-in ammatory cell counts of neutrophils, lymphocytes and platelets, which may re ect the in ammatory status of the body more comprehensively than the three previously mentioned in ammatory indexes [33,34]. Researches have suggested that all four systemic in ammatory indexes are signi cantly associated with adult HTN, of which SII may be a speci c and superior marker for HTN in adults [35].…”

Section: Introductionmentioning

confidence: 99%

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Association between systemic inflammation markers and high blood pressure among children and adolescents: NHANES, 1999-2018

Zhang

Yin

et al. 2023

Preprint

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Background Few studies have estimated the associations of systemic inflammation markers and High blood pressure (HBP) in the pediatric population. Methods Basing on data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018, we assessed the associations between four inflammation-related factors based on blood cell counts: systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to lymphocyte-ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and risk for pediatric HBP by estimating odds ratios (ORs) using multivariable logistic regression models. Results A total of 17,936 children aged 8 to 19 years were included in the analysis, representing about 36.7 million American children. The prevalence rates of elevated blood pressure (EBP) and hypertension (HTN) were 15.79% and 6.77%, respectively. The results showed that the ORs for EBP per standard deviation (SD) increment in SII and NLR were estimated at 1.11 [95% confidence interval (95%CI): 1.04, 1.17] and 1.08 (95%CI: 1.02, 1.15), respectively; and the OR for EBP per SD increment in LMP were estimated at 0.90 (95%CI: 0.83, 0.96). These associations were stronger in boys and younger children. Conclusions The study suggested that inflammation-related factors could serve as easily accessible early biomarkers for HBP risk prediction and prevention in children and adolescents.

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Section: Discussionsupporting

confidence: 46%

Section: Introductionmentioning

confidence: 99%

Association between systemic inflammation markers and high blood pressure among children and adolescents: NHANES, 1999-2018

Zhang

Yin

et al. 2023

Preprint

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“…Endothelial dysfunction, a cause and effect of HTN, is preceded by alterations in the expression of cytokines and of endothelial cell receptors, as well as dysregulation in vascular smooth muscle, platelet and monocyte function [ 56 ]. Lymphocyte to monocyte ratio (LMR) was negatively associated with the prevalence of HBP in a recent cross-sectional study [ 57 ]. MLR was also a mortality predictor in COVID-19 patients [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Relationships between Easily Available Biomarkers and Non-Dipper Blood Pressure Pattern in Patients with Stable Coronary Artery Disease

Drugescu

Roca

Zota

et al. 2023

Life

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Introduction. Chronic inflammation plays an essential role in the pathophysiology of both arterial hypertension (HTN) and coronary artery disease (CAD), and is more pronounced in individuals with a non-dipper circadian blood pressure (BP) pattern. A non-dipping BP pattern is in turn is associated with increased cardiovascular morbi-mortality, and a higher risk of atherosclerotic events. Neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR) and platelet to lymphocyte ratio (PLR) are readily available predictors of systemic inflammation and cardiovascular risk. The purpose of our study is to evaluate whether NLR, MLR and PLR can be used as cost-effective predictors of a non-dipping blood pressure pattern in hypertensive patients with stable CAD. Materials and Methods: We performed a cross-sectional retrospective analysis that included 80 patients with hypertension and stable CAD (mean age 55.51 ± 11.83 years, 71.3% male) referred to a cardiovascular rehabilitation center. All patients underwent clinical examination, 24 h ambulatory blood pressure monitoring (ABPM) and standard blood analysis. Results: Baseline demographic characteristics were similar in both groups. Patients with non-dipper pattern had significantly higher NLR (median = 2, IR (2–3), p < 0.001), MLR (median = 0.31, IR (0.23–0.39), p < 0.001) and PLR (median = 175, IR (144–215), p < 0.001) compared to dippers. Conclusion: Our results suggest that MLR and PLR are inexpensive and easily accessible biomarkers that predict a non-dipping pattern in hypertensive patients with stable CAD.

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“…Calculation were as follows: SII = (neutrophils Â platelets)/lymphocytes; NLR = neutrophils/lymphocytes; PLR = platelets/lymphocytes and LMR = lymphocytes/monocytes (Xu et al, 2023). During the periodontal examinations at the MEC, probing depths and clinical attachment levels (CALs) were assessed.…”

Section: Study Variables and Criteriamentioning

confidence: 99%

Visceral adipose tissue increases the risk of periodontal disease: Results from the 2011–2014 National Health and Nutrition Examination Survey and Mendelian randomization analysis

Qu,

Wang,

Shen

2023

J Clinic Periodontology

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AimThis study aimed to investigate the relationship and potential causal effect of visceral adipose tissue (VAT) on periodontal disease (PD). Despite prior research on this, there has been no definitive conclusion. Therefore, this study aimed to provide additional insight into these associations.Materials and MethodsThis study used data from the National Health and Nutrition Examination Survey 2011–2014 to examine the association between VAT and PD in a cross‐sectional study design. Various analytical methods were employed, such as multivariable logistic regression, restricted cubic spline analysis, and p‐value for trend. Additionally, two‐sample Mendelian randomization (MR) analysis was performed to evaluate the potential causal effect of VAT on PD risk. These methods enabled us to evaluate the association between VAT and PD and to establish whether VAT could be a causal factor in PD development.ResultsThe study examined a sample of 3535 participants, and the findings suggested that higher VAT levels were associated with an increased risk of PD. In addition, multivariable regression analysis conducted in six models revealed a statistically significant association between VAT and PD risk. Restricted cubic spline analysis showed an inverted U‐shaped association between VAT and PD, with a turning point at 733 g of VAT. Finally, a two‐sample MR analysis provided evidence for a potential causal relationship between VAT and PD risk, with an odds ratio of 1.16 (95% confidence interval: 1.02–1.33, p = .027) per kg increase in genetically predicted VAT.ConclusionsThe results of this study suggest that there is a significant association between VAT and PD and that VAT could be a potential causal factor in PD risk. Our results also suggest that although there is a potential link between VAT levels and PD risk, the effect size is modest. Therefore, interventions designed to reduce VAT levels should not be considered a primary strategy for PD risk reduction but could be one of many strategies used in a comprehensive approach to PD risk management.

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Systemic inflammation markers and the prevalence of hypertension: A NHANES cross-sectional study

Cited by 63 publications

References 38 publications

Association between systemic inflammation markers and high blood pressure among children and adolescents: NHANES, 1999-2018

Association between systemic inflammation markers and high blood pressure among children and adolescents: NHANES, 1999-2018

Relationships between Easily Available Biomarkers and Non-Dipper Blood Pressure Pattern in Patients with Stable Coronary Artery Disease

Visceral adipose tissue increases the risk of periodontal disease: Results from the 2011–2014 National Health and Nutrition Examination Survey and Mendelian randomization analysis

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