Systemic Inflammation Markers in Patients With Aggressive Periodontitis: A Pilot Study

Shi, Dong; Meng, Hua; Xu, Li; Zhang, Li; Chen, Zhibin; Feng, Xiaodong; Lu, Ruifang; Sun, X. F.; Ren, Xiang

doi:10.1902/jop.2008.080192

Cited by 58 publications

(56 citation statements)

References 31 publications

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“…The secretion of cytokines also promotes production of lymphocytes [55,56]. The white blood cell count was found to be higher in CP patients in our study which is consistent with Shi’s study [57]. …”

Section: Discussionsupporting

confidence: 90%

Comparing serum levels of cardiac biomarkers in cancer patients receiving chemotherapy and subjects with chronic periodontitis

et al. 2012

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BackgroundChronic periodontitis (CP) is a chronic inflammation associated with elevations of several inflammatory and cardiac markers. Studies implicated CP as one of the etiologies in coronary heart disease (CHD). Cardiotoxicity is a major complication of anticancer drugs, including anthracyclines and 5-fluorouracil (5FU). The most severe cardiac complications are heart failure, arrhythmia and coronary heart disease (CHD). In this study, we compared the level of inflammatory factors and cardiac markers between chronic periodontitis patients and cancer patients receiving chemotherapy.Methods108 blood samples of periodontally healthy subjects were obtained on random from Hong Kong Red Cross, and these represented the controlled population. Forty-four patients diagnosed with chronic periodontitis were recruited from the West China Hospital of Stomatology, Sichuan University. They have received scaling and root planning with mean pocket depths of 6.05 mm. Thirty breast cancer patients diagnosed with invasive ductal carcinoma from UNIMED Medical Institute, Hong Kong gave consent to participate in this study. They received 4 cycles of 500mg/m2 5-fluorouracil, 75 mg/m2 epirubicin and 500mg/m2 cyclophosphamide at a 3-week interval between each cycle. Peripheral venous blood from each group was taken for measurement of blood cells, inflammatory marker (P-selectin, high sensitvity C-reactive protein) and cardiac markers (troponin T; troponin I; N-terminal pro brain natriuretic peptide (Nt-proBNP) and Lactate dehydrogenase (LDH).ResultsThe lymphocyte count was higher (p < 0.05) in periodontitis patients than the other two groups, and more neutrophils (p < 0.05) were seen in cancer patients receiving chemotherapy. The two test groups demonstrated higher levels (p < 0.01) of inflammatory and cardiac markers than the control group.ConclusionsThe elevated cardiac markers found in periodontitis patients suggested that they may carry potential risks in developing cardiac lesions. Troponin T, troponin I, pro-BNP, LDH and high sensitvity C-reactive protein may be used as markers to monitor cardiac lesions in chronic inflammatory patients.

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Section: Discussionsupporting

confidence: 90%

Comparing serum levels of cardiac biomarkers in cancer patients receiving chemotherapy and subjects with chronic periodontitis

et al. 2012

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“…WBC is useful clinically as an index of conditions involving inflammation . It was demonstrated that a positive association existed between periodontitis and WBC . In the present study, the association between BMI and WBC count was a U‐shaped relationship as well, and 22 was the optimal BMI associated with the lowest WBC count.…”

Section: Discussionsupporting

confidence: 65%

“…WBC (white blood count) is useful clinically as an index of a variety of conditions, particularly those involving inflammation . Numerous researches demonstrated that WBC was positively correlated with periodontitis . Kweider et al.…”

mentioning

confidence: 99%

A novel U‐shaped relationship between BMI and risk of generalized aggressive periodontitis in Chinese: A cross‐sectional study

Shi

Song

et al. 2018

Journal of Periodontology

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“…It is used to examine the changes in overall protein secretion in biologic fluids or to look for differences in the ratio of specific proteins to total protein that occur in response to physiological changes. Measurement of total protein was used to normalize concentrations of various salivary proteins in different samples since concentrations can vary significantly in response to stimulation or alterations of saliva flow [17][18][19][20].…”

Section: Measurement Of Total Protein and Balpmentioning

confidence: 99%

The Salivary Bone Spesific Alkaline Phosphatase in Relation to Pubertal Growth Phase in Indonesian Children

Wijaya

Kusdhany

Redjeki

et al. 2017

Asian J Pharm Clin Res

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Objective: Objective of the study was to evaluate the level of salivary bone-specific alkaline phosphatase (BALP) during the pubertal growth phases in Indonesian children. Methods:The study conducted on 64 boys and 72 girls who were age group of 8-18 years old were randomly selected. Salivary BALP level were estimated using enzyme-linked immunosorbent assay commercial kits and pubertal growth phase were assessed using cervical vertebral maturation (CVM) method according to Baccetti. Mean salivary BALP was compared based on pubertal growth groups by analysis of variance test. Results:Test revealed no significant differences between groups with p=0.312. The highest mean of salivary BALP level was found in the prepeak pubertal growth phase (CVM Stage 1-2), and the lowest one was detected in the postpeak pubertal growth phase (CVM Stage 5-6). Conclusion:The using of salivary BALP as a biomarker for pubertal growth prediction is questionable.

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Systemic Inflammation Markers in Patients With Aggressive Periodontitis: A Pilot Study

Abstract: Patients with AgP may have elevated peripheral leukocyte numbers and serum globulin levels as well as decreased serum albumin levels and albumin/globulin ratios compared to controls. These changes might be associated with the severity of periodontal destruction.

Cited by 58 publications

References 31 publications

Comparing serum levels of cardiac biomarkers in cancer patients receiving chemotherapy and subjects with chronic periodontitis

Comparing serum levels of cardiac biomarkers in cancer patients receiving chemotherapy and subjects with chronic periodontitis

A novel U‐shaped relationship between BMI and risk of generalized aggressive periodontitis in Chinese: A cross‐sectional study

The Salivary Bone Spesific Alkaline Phosphatase in Relation to Pubertal Growth Phase in Indonesian Children

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