Systemic Inflammation, Oxidative Damage to Nucleic Acids, and Metabolic Syndrome in the Pathogenesis of Psoriasis

Borská, Lenka; Kremláček, Jan; Andrýs, Ctirad; Krejsek, Jan; Hamáková, Květoslava; Borský, Pavel; Palička, Vladimír; Řeháček, Vít; Málková, Andrea; Fiala, Zdeněk

doi:10.3390/ijms18112238

Cited by 46 publications

(48 citation statements)

References 34 publications

(63 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, the inflammation induced by the overweight might be the spark that initiates the fire and the inflammation caused by psychosis would be the second hit [16,22,25]. The fact that the largest differences in the basal cytokine levels between patients and healthy volunteers were found in the overweight group might be explained by the additive proinflammatory effect of both excess weight and psychosis [4,22]. This is supported by the analyses comparing the basal serum cytokine levels between normal-weight and overweight individuals within the groups of healthy volunteers and patients; Fig.…”

Section: Discussionmentioning

confidence: 99%

The effect of excess weight on circulating inflammatory cytokines in drug-naïve first-episode psychosis individuals

Ruíz

Riesco-Dávila

Foz

et al. 2018

J Neuroinflammation

View full text Add to dashboard Cite

Background: Low-grade inflammation has been repeatedly associated with both excess weight and psychosis. However, no previous studies have addressed the direct effect of body mass index (BMI) on basal serum cytokines in individuals with first-episode psychosis (FEP). Objectives: The aim of this study is to analyze the effect of BMI on basal serum cytokine levels in FEP patients and control subjects, separating the total sample into two groups: normal-weight and overweight individuals. Methods: This is a prospective and open-label study. We selected 75 FEP patients and 75 healthy controls with similar characteristics to patients according to the following variables: sex, age, and cannabis and tobacco consumption. Both controls and patients were separated into two groups according to their BMI: subjects with a BMI under 25 were considered as normal weight and those with a BMI equal to or more than 25 were considered as overweight. Serum levels of 21 cytokines/chemokines were measured at baseline using the Human High Sensitivity T Cell Magnetic Bead Panel protocol from the Milliplex® Map Kit. We compared the basal serum levels of the 21 cytokines between control and patient groups according to their BMI. Results: In the normal-weight group, IL-8 was the only cytokine that was higher in patients than in the control group (p = 0.001), whereas in the overweight group, serum levels of two pro-inflammatory cytokines (IL-6, p = 0.000; IL-1β, p = 0.003), two chemokines (IL-8, p = 0.001; MIP-1β, p = 0.001), four Th-1 and Th-2 cytokines (IL-13, p = 0.009; IL-2, p = 0.001; IL-7, p = 0.001; IL-12p70, p = 0.010), and one Type-3 cytokine (IL-23, p = 0.010) were higher in patients than in controls. Conclusions: Most differences in the basal serum cytokine levels between patients and healthy volunteers were found in the overweight group. These findings suggest that excess weight can alter the homeostasis of the immune system and therefore may have an additive pro-inflammatory effect on the one produced by psychosis in the central nervous system.

show abstract

Section: Discussionmentioning

confidence: 99%

The effect of excess weight on circulating inflammatory cytokines in drug-naïve first-episode psychosis individuals

Ruíz

Riesco-Dávila

Foz

et al. 2018

J Neuroinflammation

View full text Add to dashboard Cite

show abstract

“…Psoriasis is one of the most serious autoimmune diseases with numerous of obvious pathological changes in the lesional skin, including epidermal abnormal proliferation, aberrant differentiation and so on, and these events would induce erythematous plaques on the patient's skin, which is itchy and even very painful . Due to the complex pathogenesis of psoriasis, there are very few effective treatments for the patients of psoriasis .…”

Section: Discussionmentioning

confidence: 99%

“…Numerous of researches were performed to explore the mechanisms of psoriasis, results indicated that the pathogenesis of psoriasis is extremely complicated, and it may cause by the interaction between an overreacted immune system and diverse of environmental stimulus, as well as various genetic factors . Mammalian target of rapamycin (mTOR) signalling pathway, implicated in the modulation of cell proliferation, differentiation and apoptosis, was reported to be involved in the initiation and development of psoriasis, recently .…”

Section: Introductionmentioning

confidence: 99%

Rapamycin ameliorates psoriasis by regulating the expression and methylation levels of tropomyosin viaERK1/2 andmTORpathways in vitro and in vivo

Gao

2018

Experimental Dermatology

View full text Add to dashboard Cite

Psoriasis is a chronic inflammatory disease, affecting more than millions of people in the world. Recently, the mTOR inhibitor rapamycin (RAPA) was reported to be involved in the pathogenesis of psoriasis. However, the underlying mechanism remains unclear. Haematoxylin and eosin staining was used to examine the effects of RAPA on inflammatory level of lesional tissues from patients with psoriasis and animal models. Quantitative real-time PCR, immunohistochemistry and western blot assay were performed to assess the effects of RAPA on tropomyosins (TPMs) expression in patients with psoriasis, cell models and animal models. Phalloidin staining was used to assess the RAPA effects on cell skeleton. The effects of RAPA on cell proliferation and cell cycle were detected by CCK-8 assay, EdU staining and flow cytometry. Methylation status of TPMs was analysed by methylation-specific PCR. The expression of TPM1 and TPM2 was significantly downregulated, while their methylation level was obviously higher in the lesional tissues, cell models and animal models of psoriasis. After treated with RAPA, the expression and methylation levels of TPMs were all restored in the cell models and animal models of psoriasis. RAPA inhibited cell proliferation and decreased the ratio of S phase cell in Hacat or human epidermal keratinocytes cell models of psoriasis. Finally, the activated ERK1/2 and mTOR pathways in the cell model and animal model of psoriasis were suppressed by the treatment of RAPA. RAPA could be used as an effective agent for the treatment of psoriasis by decreasing the methylation level of TPM1 and TPM2 via inhibiting the ERK1/2 and mTOR signalling pathways.

show abstract

“…A meta-analysis involving 78 studies (7,852 patients, 3,085 with severe psoriasis) showed moderate but significantly increased CRP and pro-inflammatory cytokine (IL-1b, IL-6, TNF-α) concentrations in sera of psoriatic patients, especially the ones with severe psoriasis [46]. However, one of the recent studies suggests that systemic inflammation associated with an increase in CRP in psoriatic patients, which causes oxidative damage of DNA/ RNA, is a result of inflammation associated with the presence of exanthemata rather than concomitant metabolic syndrome in those patients [47].…”

Section: Copd As a Systemic Inflammationmentioning

confidence: 99%

Are psoriasis and psoriatic arthritis associated with chronic obstructive pulmonary disease?

Owczarczyk‐Saczonek¹,

Owczarczyk²,

Krajewska–Włodarczyk³

et al. 2019

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease is a chronic inflammation affecting the peripheral airways and pulmonary parenchyma, leading to irreversible and progressive airflow limitation. In recent years attention has been paid to more frequent coexistence with psoriasis. Both diseases are provoked by similar factors, such as smoking, abdominal obesity, lack of physical activity, and concomitance with the metabolic syndrome. In addition, similarities in pathogenesis, regarding the roles of Th1 and Th17 can be found, resulting in an increase in the proinflammatory cytokines levels. Both in psoriasis and chronic obstructive pulmonary disease, an increased activity of proteases produced by neutrophils and adhesion molecules is observed. In addition, neutrophils are an abundant source of inflammation mediators, including reactive oxidants and lipid mediators with chemotactic activity. Awareness of the increased risk of developing chronic obstructive pulmonary disease in psoriatic patients, allows to implement preventive and therapeutic actions such as smoking cessation or treatment of the inflammatory processes. STRESZCZENIEPrzewlekła obturacyjna choroba płuc to przewlekły stan zapalny, który obejmuje obwodowe drogi oddechowe oraz miąższ płucny i prowadzi do nieodwracalnego oraz postępującego ograniczenia przepływu powietrza. W ostatnich latach zwraca się uwagę na częstsze współistnienie przewlekłej obturacyjnej choroby płuc z łuszczycą. Obie choroby są wywoływane przez podobne czynniki, takie jak palenie tytoniu, otyłość brzuszna i brak aktywności fizycznej, oraz wiążą się z zespołem metabolicznym. Ponadto można się doszukać podobieństw elementów patogenezy dotyczących roli Th1 i Th17, co skutkuje wzrostem stężenia Review aRticle/Praca Poglądowa Are psoriasis and psoriatic arthritis associated with chronic obstructive pulmonary disease? Czy łuszczyca i łuszczycowe zapalenie stawów mają związek z przewlekłą obturacyjną chorobą płuc?DermatologyReview/PrzeglądDermatologiczny2019/2 cytokin prozapalnych. Zarówno w łuszczycy, jak i przewlekłej obturacyjnej chorobie płuc obserwuje się zwiększoną aktywność proteaz produkowanych przez neutrofile i cząsteczek adhezyjnych. Dodatkowo neutrofile są obfitym źródłem mediatorów stanu zapalnego, w tym reaktywnych utleniaczy, mediatorów lipidowych o aktywności chemotaktycznej. Świadomość podwyższonego ryzyka rozwoju przewlekłej obturacyjnej choroby płuc u pacjentów z łuszczycą pozwala na podjęcie działań profilaktycznych i terapeutycznych oraz kontrolowanie czynników ryzyka, takich jak zaprzestanie palenia tytoniu i leczenie procesu zapalnego.

show abstract

Systemic Inflammation, Oxidative Damage to Nucleic Acids, and Metabolic Syndrome in the Pathogenesis of Psoriasis

Cited by 46 publications

References 34 publications

The effect of excess weight on circulating inflammatory cytokines in drug-naïve first-episode psychosis individuals

The effect of excess weight on circulating inflammatory cytokines in drug-naïve first-episode psychosis individuals

Rapamycin ameliorates psoriasis by regulating the expression and methylation levels of tropomyosin viaERK1/2 andmTORpathways in vitro and in vivo

Are psoriasis and psoriatic arthritis associated with chronic obstructive pulmonary disease?

Contact Info

Product

Resources

About