Systemic Inflammatory Index and Platelet-to-Lymphocyte Ratio Predict Mortality in Patients with Acute Myocardial Infarction

Abstract

In this study, we aimed to evaluate the relationship between the laboratory parameters of platelet volume / lymphocyte ratio (PLR) and systemic inflammatory index (SII) with prognosis and mortality in patients with hospitalized GFR (Glomerular filtration rate) <60 ml / min and a diagnosis of acute myocardial infarction (AMI). This study was designed as a retrospective cohort study. 235 myocardial infarction (MI) patients over the age of 18 and with GFR <60 ml / min, hospitalized in our hospital between January 01, 2016 and January 01, 2019, were included in the study. The patients were divided into 2 groups as survival and mortality group. The two groups were compared in terms of demographic characteristics, clinical laboratory data (symptoms, comorbidities, laboratory findings, GFR, coronary angiography, medications and complications). Platelet -lymphocyte ratio (PLR) was obtained by dividing platelet count to lymphocyte count. Systemic inflammatory index (SII) was found by multiplying neutrophil count and PLR value. The mean age of the survival group was 67.1±12,8 years. In the mortality group, the mean age was 69.55±11,1 years. PLR and SII levels were significantly higher in the mortality group compared to the survival group (p=0.002, p=0.029, respectively). According to the results of ROC analysis in mortality group patients, it was found that sensitivity 59.1% and specificity 70.4% for PLR (p=0.002); sensitivity 54.5% and specificity 60.9% for SII (p=0.

Malnutrition-Inflammation Liaison in Predicting AKI following OPCABG in Diabetics: Role of a Novel Monocyte/High-Density Lipoprotein × Albumin Ratio

“…In another evaluation of 145 patients who underwent transcatheter aortic valve implantation by Karahan and Okuyan, the mortality remarkably increased from 4.1 to 76.1% owing to an elevation of MHR above the median value of 13.73. 12 Alongside a 50% mortality risk accentuation for every 1 unit increase in MHR in the study, the ratio correlated positively with C-reactive protein, suggesting a proinflammatory predisposition at the cornerstone of an enhanced mortality. 12 Albeit an underlying CAD being implicated for such an exorbitant mortality association of MHR by Karahan and Okuyan, Dolapoglu et al 29 failed to discover any association between MHR and morbidity–mortality following CABG.…”

“…12 Alongside a 50% mortality risk accentuation for every 1 unit increase in MHR in the study, the ratio correlated positively with C-reactive protein, suggesting a proinflammatory predisposition at the cornerstone of an enhanced mortality. 12 Albeit an underlying CAD being implicated for such an exorbitant mortality association of MHR by Karahan and Okuyan, Dolapoglu et al 29 failed to discover any association between MHR and morbidity–mortality following CABG. Despite a degree of contradiction in the preliminary reports, the recent description of MHR as a biomarker of diabetic nephropathy by Karatas et al 20 supports our finding of an AKI-predictive value of MHAR in diabetic cardiac surgical patients.…”

“…In the context of a CSA-AKI-predictive value of MHAR outlined in the present study, the literature is replete with the prognostic importance of preoperative MHR 10 11 12 13 14 15 16 and albumin. 21 22 While substantial research proposes a prognostic role of MHR in nonoperative settings (including cardiac patients), 13 14 15 16 there remains a dearth of studies featuring the role of the former in cardiac surgery.…”

“…8 Albumin classifies as a negative acute phase reactant 9 and hence, hypoalbuminemia can significantly contribute to an ongoing inflammatory process. Furthermore, an elevated monocyte/high-density lipoprotein ratio (MHR) has been recently described to be a parsimonious proinflammatory marker of prognostic importance in operative 10 11 12 and nonoperative CAD settings. 13 14 15 16 The elucidation of coexistence of low serum albumin levels and high MHR in postcoronary artery bypass grafting (CABG) patients with saphenous vein graft disease by Akboga et al, is intriguing.…”