Systemic inflammatory response indicators in rabbits (Oryctolagus cuniculus) experimentally infected with sporulated oocysts of Eimeria stiedai (Apicomplexa: Eimeriidae)

Freitas, Fagner Luiz da Costa; Yamamoto, Beatriz Lie; Freitas, Wagner Luiz da Costa; Fagliari, José Jurandir; Almeida, Katyane de Sousa; Machado, Rosangela Zacarias; Machado, C. R.

doi:10.1590/s1984-29612011000200006

Cited by 13 publications

(9 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To our knowledge, our study is the first to examine the relationship between Hp and SAA levels and experimental infections with Eimeria in cattle, although studies on SAA and Hp levels in response to Eimeria infection have been performed in rabbits and goats. Rabbits infected with 10,000 Eimeria stiedai oocysts were reported by Freitas et al (2011) to exhibit increased APP concentrations of ceruloplasmin, transferrin and Hp from 7 to 28 days post-infection. Infection of goat kids with 1,000 or 100,000 sporulated Eimeria arloingi oocysts was also reported to increase blood levels of Hp and SAA (Hashemnia et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Systemic acute phase proteins response in calves experimentally infected with Eimeria zuernii

Lassen

Bangoura

Lepik

et al. 2015

Veterinary Parasitology

View full text Add to dashboard Cite

Acute phase proteins (APPs) have been demonstrated to be useful in evaluating general health stress and diseases in cattle. Serum amyloid A (SAA) and haptoglobin (Hp) are APPs that are produced during inflammation, and likely play a role in host immunological defence against Eimeria infection and the associated intestinal tissue damage. We investigated the involvement of SAA and HP in an experimental study, including three groups of calves: a control group (group 0, n=11), and two groups infected with either 150,000 or 250,000 Eimeria zuernii oocysts (group 1 (n=11) and group 2 (n=12), respectively). The calves were monitored for 28 days and data was collected on oocyst excretion, faecal score, animal weight, and SAA and Hp serum concentrations. Generalized linear mixed models showed that the clinical symptoms, indicated by an increase in the number of oocysts in the faeces and severe diarrhoea, manifested at patency for group 1 and 2. Serum Hp and SAA levels also increased during this period. Hp appeared to be a more sensitive marker than SAA, and differences between groups 1 and 2 were observed only for Hp. Linear regression models showed a negative association between weight gain and Hp concentrations, calculated as the area under the curve (AUC) during the overall experimental period and the patency period. A similar result was seen for SAA only during the patency period. This result supports the assumption that reduced weight gain due to E. zuernii infection is an immunologically driven process that involves an increase in APPs. A random intercept regression model of oocyst shedding groups showed that calves shedding 1-500 oocysts had reduced concentrations of Hp, indicating that a different immunological reaction occurs during mild shedding of E. zuernii oocysts than during more intensive shedding. A similar model was used to examine associations between faecal scores and Hp concentrations for each group. Group 2 calves with haemorrhagic diarrhoea displayed higher Hp levels than calves in that group with lower faecal scores, which may be in response to an increased demand for Hp in the repair process as a result of haemolysis. APPs seem to play an important role in determining the course of E. zuernii infection in calves, which may enhance our understanding of the immunological reaction and development of this disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Systemic acute phase proteins response in calves experimentally infected with Eimeria zuernii

Lassen

Bangoura

Lepik

et al. 2015

Veterinary Parasitology

View full text Add to dashboard Cite

show abstract

“…Serum bilirubin levels can rise to 305 mg/ dl, increasing as soon as day 6 of infection and increasing through days 20-24 before moderating (Rose, 1959). Leukocytosis and anemia can be observed and acute phase proteins are notably increased by 7 days post infection (Freitas et al, 2011). Diagnosis can be made by examination of fecal material, by either flotation or concentration methods.…”

Section: Hepatic Coccidiosismentioning

confidence: 99%

Biology and Diseases of Rabbits

Nowland

Brammer

García

et al. 2015

Laboratory Animal Medicine

View full text Add to dashboard Cite

“…In this study, a significant increase in PFA was found two months before the animals showed clinical signs (MARTINEZ-SUBIELA et al, 2014). Additionally, the analysis of PFA has yielded promising results in autoimmune disorders in calves (BEZUIDENHOUT & PRETORIUS, 2020), infectious diseases in cats and dogs (PALTRINIERI et al, 2007;KOCATURK et al, 2010), parasitic diseases in rabbits and dogs (FREITAS, 2011;MYLONAKIS et al, 2012;CÉRON et al 2018) and tumoral diseases in cats (SELTING et al, 2000). However, the correlation between these proteins and trauma is not yet fully understood (CHRISTENSEN et al, 2015).…”

Section: Clinic and Surgerymentioning

confidence: 58%

Correlation of serum acute-phase proteins with bone repair in rabbits (Oryctolagus cuniculus) submitted to partial radio ostectomy

et al. 2021

View full text Add to dashboard Cite

Bone trauma triggers an acute inflammatory response, which can alter the serum concentration of acute-phase proteins (PFA). We aimed to evaluate the effectiveness of PFA measurement as a laboratory biomarker for inflammation related to bone regeneration. A partial ostectomy of the right radius was performed on 22 young male rabbits. The complete blood count, albumin, ceruloplasmin, haptoglobin, C-reactive protein, and transferrin levels were recorded and correlated with the radiographic evolution of bone healing. Statistically the best correlations with the inflammatory process and radiological findings were reported with haptoglobin and transferrin compared to the other measured PFAs. Haptoglobin and transferrin showed a maximum peak 24 and 36 hours after surgery, respectively. Transferrin displayed signs of decrease in the first 6 hours after surgery, in advance of the leukocyte response. The measurement of acute-phase proteins proved to be viable, considering the conditions in which the present study was carried out. Among all variables studied, haptoglobin and transferrin showed best correlation with the inflammatory process of bone healing. Additional studies are needed to determine the sensitivity of acute-phase proteins as predictors of complications in the treatment of fractures.

show abstract

Systemic inflammatory response indicators in rabbits (Oryctolagus cuniculus) experimentally infected with sporulated oocysts of Eimeria stiedai (Apicomplexa: Eimeriidae)

Cited by 13 publications

References 20 publications

Systemic acute phase proteins response in calves experimentally infected with Eimeria zuernii

Systemic acute phase proteins response in calves experimentally infected with Eimeria zuernii

Biology and Diseases of Rabbits

Correlation of serum acute-phase proteins with bone repair in rabbits (Oryctolagus cuniculus) submitted to partial radio ostectomy

Contact Info

Product

Resources

About