Systemic inflammatory response syndrome after major abdominal surgery

AlSomali, Abdullah; Mobarki, Abdullah A; Almuhanna, Mohammed; Alqahtani, Abdullah M.; Alhawali, Ziyad; Almalki, Ahmed; Al-Nasser, Abdallah; Alghamdi, Abdulaziz; Alfaifi, Abdulrahman; Alghamdi, Ali

doi:10.24911/ijmdc.51-1544391769

Cited by 2 publications

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“…Despite ongoing advances in surgical equipment cleaning and good personal hygiene to undertake exploratory care and management operations in countries including Saudi Arabia [ 1 , 2 ], the rate of death of post-surgical widespread inflammatory disease syndrome (SIRS) in children keeps rising. The accessibility of quick, accurate, and particular tests is highly desired by doctors in the intensive care unit (ICU) for detecting infected patients and to prevent patients from the advantage of immediate basic antibiotic therapy [ 3 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Procalcitonin in Assessing Outcomes in Pediatrics Severe Trauma Cases: A Three-Year Experience from a Tertiary Hospital

Albuali¹

2023

BioMedicine

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Summary Background Although procalcitonin levels are raised in patients with systemic inflammation, its usage in pediatric patients, particularly those in the intensive care unit who are most susceptible to sepsis. Methods It is a retrospective research study that included pediatric patients aged more than two weeks who were brought to the King Fahd Hospital of the University’s PICU owing to serious trauma or post-acute postoperative occurrences from January 2017 to December 2019. At 24 h after admission, data such as age, gender, comorbidities, trauma severity as measured by the Injury Severity Score, and PRISM III score were collected. Results Following a surgery abscess, there were a total of 39 (15.9%) deaths. Patients who died during their hospital stay had significantly higher mean levels of biomarkers such as PRISM III, PCT at 24 h, PCT 48–72 h, and PCT at day 5 (p = 0.001). The area under the ROC curve for PCT level 48/72 h was 0.89 (% CI: 0.85–0.93), p = 0.001, indicating that PCT had highly significant predictive validity in predicting in-hospital mortality at the best cutoff point of >1.35 with a high level of accuracy and precision of 82.1% and 82.0%, respectively. Conclusion The serum procalcitonin level (PTCL) can help predict the in-hospital prognosis of pediatrics that has had surgery. A combined control system is designed based on PTC expression for the examination of a patient receiving medication over a longer length of time.

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Section: Introductionmentioning

confidence: 99%

The Impact of Procalcitonin in Assessing Outcomes in Pediatrics Severe Trauma Cases: A Three-Year Experience from a Tertiary Hospital

Albuali¹

2023

BioMedicine

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Systemic Anti-inflammatory Activity of American Cockroach (Periplaneta americana) Extract: A Molecular Docking Study

Aritonang,

Gunanti,

Purwono

et al. 2024

MKH

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Surgery can trigger systemic inflammatory response syndrome. This study aims to determine the effectiveness of Periplaneta americana cockroach extract as an oral systemic anti-inflammatory agent using molecular docking. The molecular docking method consisted of five steps. The first step was preparing the TNF-α converting enzyme (TACE) receptor as a native ligand, dexamethasone as a control ligand, and three test ligands of Periplaneta americana cockroach extract. The second step was docking preparation. The third step was analyzing Gibbs free energy (∆G) and root mean square deviation (RMSD). The fourth step was docking the test and control ligands with TACE. The fifth step was analyzing ∆G, inhibition constant (Ki), visualization of two- and three-dimensional interactions, percentage of binding site similarity (%BSS), and the rule of five (Ro5) on test ligands. The ∆G results for the native, control, and test ligands 1, 2, and 3 were -12.8, -7.1, -7.7, -6.9, and -9.0 kcal/mol, respectively. The Ki values for the native, control, and test ligands 1, 2, and 3 were 4.091, 6.205, 2.253, 9.521, and 2.507 µM, respectively. The results of the Ro5 analysis suggested that the three test ligands satisfied Lipinski’s rule of five. This study concluded that Periplaneta americana cockroach extract is an effective oral systemic anti-inflammatory agent.

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Systemic inflammatory response syndrome after major abdominal surgery

Cited by 2 publications

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The Impact of Procalcitonin in Assessing Outcomes in Pediatrics Severe Trauma Cases: A Three-Year Experience from a Tertiary Hospital

The Impact of Procalcitonin in Assessing Outcomes in Pediatrics Severe Trauma Cases: A Three-Year Experience from a Tertiary Hospital

Systemic Anti-inflammatory Activity of American Cockroach (Periplaneta americana) Extract: A Molecular Docking Study

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