Systemic Inflammatory Response Syndrome and postoperative complications after orthognathic surgery

Abstract

Symptoms of Systemic Inflammatory Response Syndrome (SIRS) presenting immediately after surgery have lately been regarded as potential warnings of impending postoperative complications and multiple organ failure. Reports discussing the relationship between operative stress and SIRS are found in the field of digestive surgery, but not in that of oral surgery. Sixty-five patients with jaw deformity who had undergone maxillary and mandibular orthognathic surgery (Le Fort I osteotomy and sagittal splitting ramus osteotomy) between September 2003 and October 2006 were involved in this study. A search based on the SIRS diagnostic criteria resulted in assignment of 33 cases to the SIRS group and 32 cases to the non-SIRS group. Postoperative complications occurred in 27.3% of the SIRS group and 0.0% of the non-SIRS group (pϽ0.01). In four cases, a postoperative fluctuation in IL-6 level evaluated. These results suggest the importance of careful management of postoperative SIRS patients in preventing complications.

Hyperglycaemia, inflammation, RAS activation: Three culprits to blame for acute kidney injury emerging in healthy rats during general anaesthesia

“…Major surgery under local or general anaesthesia is strongly associated with dysfunction of the immune system 1–5,18,19 . In clinical practice, postoperative inflammation is generally believed to result from surgical stress and intraoperative interventions 1–5 .…”

“…Major surgery under local or general anaesthesia is strongly associated with dysfunction of the immune system 1–5,18,19 . In clinical practice, postoperative inflammation is generally believed to result from surgical stress and intraoperative interventions 1–5 . Our previous experience 15,20 prompted us to speculate that surgery‐induced stress might either aggravate or disguise the role of anaesthesia per se in postoperative renal complications.…”

“…Systemic inflammatory response is a common feature accompanying major surgery 1,2 . During surgery, inflammatory response develops in up to 44% of operated patients 2 .…”

“…Postoperative inflammation is generally believed to be the direct result of surgical stress 12 . Furthermore, a strong link exists between the magnitude of inflammation and poor perioperative outcome, 13,14 whereas blunting the intraoperative inflammation improves the postoperative scenario 1,4 …”

Value of C-Reactive Protein in the Assessment of Organ-Space Surgical Site Infections after Elective Open and Laparoscopic Colorectal Surgery

“…Although CRP has been assessed in the diagnosis of severe post-operative surgical site infections after orthopedic [24,26], pancreatic [21], and colo-rectal surgery [10,12,14,27], it has not been defined clearly at which time points the expression of CRP might be useful in the assessment of OSI. We conducted a prospective observational study to clarify the value of CRP on post-operative days two and five in patients submitted to elective colorectal surgery by open (OPEN) and laparoscopic (LAP) access.…”