Systemic Inflammatory Response Syndrome (SIRS) Score Independently Predicts Poor Outcome in Isolated Traumatic Brain Injury

Jacome, Tomas; Tatum, Danielle

doi:10.1007/s12028-017-0410-y

Cited by 47 publications

(29 citation statements)

References 39 publications

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“…The correlation between hypoalbuminemia and poor outcome of TBI patients could be explained by the brain edema and subsequent increased intracranial pressure resulted from insu cient intravascular osmolality. In addition, lower level of albumin could indicate more severe degree of systemic in ammatory response, which was discovered correlated with poor outcome of TBI patients [50,51]. In our study, the AUC value of single lactate was 0.733.…”

Section: Discussionsupporting

confidence: 48%

Lactate Albumin Ratio is Associated with Mortality in Patients with Moderate to Severe Traumatic Brain Injury

Wang¹,

He²,

Ou³

et al. 2020

Preprint

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Abstract Background: Traumatic brain injury (TBI) is a serious public health issue all over the world. This study was designed to evaluate the prognostic value of lactate to albumin ratio (LAR) on moderate to severe traumatic brain injury.Methods: Clinical data of 273 moderate to severe TBI patients hospitalized in West China Hospital between May 2015 and January 2018 were collected. Multivariate logistic regression analyses were used to explore risk factors and construct prognostic model of in-hospital mortality in this cohort. Nomogram was drawn to visualize the prognostic model. Receiver operating characteristic (ROC) curve and calibration curve were respectively drawn to evaluate discriminative ability and stability of this model.Results: Non-survivors had higher LAR than survivors (1.0870 vs 0.5286, p<0.001). Results of multivariate logistic regression analysis showed that GCS (OR=0.818, p=0.008), blood glucose (OR=1.232, p<0.001), LAR (OR=1.883, p=0.012), and red blood cell distribution (RDW)-SD (OR=1.179, p=0.004) were independent risk factors of in-hospital mortality in included patients. These four factors were utilized to construct prognostic model. The area under the ROC curve (AUC) value of single lactate and LAR were 0.733 (95%Cl; 0.673-0.794) and 0.780 (95%Cl; 0.725-0.835), respectively. The AUC value of the prognostic model was 0.868 (95%Cl; 0.826-0.909), which was higher than that of LAR (Z=2.5143, p<0.05).Conclusions: LAR is a readily available prognostic marker of moderate to severe TBI patients. Prognostic model incorporating LAR is beneficial for clinicians to evaluate possible progression and make treatment decisions in these patients.

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Section: Discussionsupporting

confidence: 48%

Lactate Albumin Ratio is Associated with Mortality in Patients with Moderate to Severe Traumatic Brain Injury

Wang¹,

He²,

Ou³

et al. 2020

Preprint

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“…21 We make a reasonable conjecture that the increase of RDW after [40][41][42][43] And markers of these mechanisms have been confirmed to be valuable in predicting outcome of patients with TBI, including catecholamine, and albumin. [44][45][46] The association between increased RDW and unfavorable outcome may be mediated through these mechanisms. In addition, increased RDW means that an increasing number of red blood cells with partially saturated hemoglobin.…”

Section: Discussionmentioning

confidence: 99%

The predictive value of RDW in AKI and mortality in patients with traumatic brain injury

Wang

et al. 2020

Clinical Laboratory Analysis

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Background Red blood cell distribution width (RDW) has been validated valuable in predicting outcome and acute kidney injury (AKI) in several clinical settings. The aim of this study was to explore whether RDW is associated with outcome and AKI in patients with traumatic brain injury (TBI). Methods Patients admitted to our hospital for TBI from January 2015 to August 2018 were included in this study. Multivariate logistic regression analysis was performed to identify risk factors of AKI and outcome in patients with TBI. The value of RDW in predicting AKI and outcome was evaluated by receiver operating characteristic (ROC) curve. Results Three hundred and eighteen patients were included in this study. The median of RDW was 14.25%. We divided subjects into two groups based on the median and compared difference of variables between two groups. The incidence of AKI and mortality was higher in high RDW (RDW > 14.25) group (31.45% vs 9.43%, P < .001; 69.81% vs 29.56%, P < .001). Spearman's method showed RDW was moderately associated with 90‐day Glasgow Outcome Scale (GOS) (P < .001). In multivariate logistic regression analysis, RDW, lymphocyte, chlorine, and serum creatinine were risk factors of AKI. And Glasgow Coma Scale (GCS), glucose, chlorine, AKI, and RDW were risk factors of mortality. The area under the ROC curve (AUC) of RDW for predicting AKI and mortality was 0.724 (0.662‐0.786) and 0.754 (0.701‐0.807), respectively. Patients with higher RDW were likely to have shorter median survival time (58 vs 70, P < .001). Conclusions Red blood cell distribution width is an independent risk factor of AKI and mortality in patients with TBI.

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“…Systemic inflammatory response syndrome (SIRS) was diagnosed based on two or more of the following conditions: body temperature <36 • C or >38 • C, heart rate > 90 beats per min, respiratory rate > 20 breaths per min, and white blood cell count <4,000 mm 3 or >12,000 mm 3 (Finkelsztein et al, 2017). The diagnosis criterion of sepsis was according to the Sepsis 2.0 for patients who met at least two of SIRS criteria plus infection (Jacome and Tatum, 2018). All patients were determined by two independent evaluators.…”

Section: Patient Recruitmentmentioning

confidence: 99%

Polygenic Risk Score for Early Prediction of Sepsis Risk in the Polytrauma Screening Cohort

Wen

Sun

et al. 2020

Front. Genet.

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Systemic Inflammatory Response Syndrome (SIRS) Score Independently Predicts Poor Outcome in Isolated Traumatic Brain Injury

Abstract: Prognostic, Level III.

Cited by 47 publications

References 39 publications

Lactate Albumin Ratio is Associated with Mortality in Patients with Moderate to Severe Traumatic Brain Injury

Lactate Albumin Ratio is Associated with Mortality in Patients with Moderate to Severe Traumatic Brain Injury

The predictive value of RDW in AKI and mortality in patients with traumatic brain injury

Polygenic Risk Score for Early Prediction of Sepsis Risk in the Polytrauma Screening Cohort

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