Systemic inhibition of mitochondrial fatty acid β-oxidation impedes zebrafish ventricle regeneration

Zhao, Yan; Lv, Hongbo; Yu, Chunxiao; Liang, Jieling; Yu, Hong; Du, Zhenyu; Zhang, Ruilin

doi:10.1016/j.bbadis.2024.167442

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

2024

DOI: 10.1016/j.bbadis.2024.167442

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Systemic inhibition of mitochondrial fatty acid β-oxidation impedes zebrafish ventricle regeneration

Yan Zhao,

Hongbo Lv,

Chunxiao Yu

et al.

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2024

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Cited by 3 publications

References 43 publications

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Tcap deficiency impedes striated muscle function and heart regeneration with elevated ROS and autophagy

Zhao,

Liang,

Liu

et al. 2024

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Tcap deficiency impedes striated muscle function and heart regeneration with elevated ROS and autophagy

Zhao,

Liang,

Liu

et al. 2024

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

View full text Add to dashboard Cite

The Biological Mechanisms and Clinical Roles of RNA-Binding Proteins in Cardiovascular Diseases

Lin,

Chu,

et al. 2024

Biomolecules

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RNA-binding proteins (RBPs) have pivotal roles in cardiovascular biology, influencing various molecular mechanisms underlying cardiovascular diseases (CVDs). This review explores the significant roles of RBPs, focusing on their regulation of RNA alternative splicing, polyadenylation, and RNA editing, and their impact on CVD pathogenesis. For instance, RBPs are crucial in myocardial injury, contributing to disease progression and repair mechanisms. This review systematically analyzes the roles of RBPs in myocardial injury, arrhythmias, myocardial infarction, and heart failure, revealing intricate interactions that influence disease outcomes. Furthermore, the potential of RBPs as therapeutic targets for cardiovascular dysfunction is explored, highlighting the advances in drug development and clinical research. This review also discusses the emerging role of RBPs as biomarkers for cardiovascular diseases, offering insights into their diagnostic and prognostic potential. Despite significant progress, current research faces several limitations, which are critically examined. Finally, this review identifies the major challenges and outlines future research directions to advance the understanding and application of RBPs in cardiovascular medicine.

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cpt1b Regulates Cardiomyocyte Proliferation Through Modulation of Glutamine Synthetase in Zebrafish

Cheng,

Ju,

Huang

et al. 2024

JCDD

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Carnitine palmitoyltransferase 1b (Cpt1b) is a crucial rate-limiting enzyme in fatty acid metabolism, but its role and mechanism in early cardiac development remains unclear. Here, we show that cpt1b regulates cardiomyocyte proliferation during zebrafish development. Knocking out entire cpt1b coding sequences leads to impaired cardiomyocyte proliferation, while cardiomyocyte-specific overexpression of cpt1b promotes cardiomyocyte proliferation. RNA sequencing analysis and pharmacological studies identified glutamine synthetase as a key downstream effector of cpt1b in regulating cardiomyocyte proliferation. Our study elucidates a novel mechanism whereby cpt1b promotes zebrafish cardiomyocyte proliferation through glutamine synthetase, which provides new perspectives on the significance of fatty acid metabolism in heart development and the interplay between fatty acid and amino acid metabolic pathways.

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Systemic inhibition of mitochondrial fatty acid β-oxidation impedes zebrafish ventricle regeneration

Cited by 3 publications

References 43 publications

Tcap deficiency impedes striated muscle function and heart regeneration with elevated ROS and autophagy

Tcap deficiency impedes striated muscle function and heart regeneration with elevated ROS and autophagy

The Biological Mechanisms and Clinical Roles of RNA-Binding Proteins in Cardiovascular Diseases

cpt1b Regulates Cardiomyocyte Proliferation Through Modulation of Glutamine Synthetase in Zebrafish

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