Systemic interventions for recurrent aphthous stomatitis (mouth ulcers)

Brocklehurst, Paul; Tickle, Martin; Glenny, Anne Marie; Lewis, Michael Alexander Oxenham; Pemberton, M. N.; Taylor, Jennifer; Walsh, Tim; Riley, Philip; Yates, Julian

doi:10.1002/14651858.cd005411.pub2

Cited by 85 publications

(87 citation statements)

References 48 publications

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“…Genetic background, stress, anxiety, food allergens, local trauma, smoking cessation, menstrual cycle, chemicals were identified as predisposing factors [5][6][7]. In a Cochrane analysis by Brocklehurst P et al [8] bacterial or viral etiology was mentioned as unlikely. The pathogenesis of RAS involves activation of T lymphocytes through cell-mediated immunity.…”

Section: Introductionmentioning

confidence: 99%

“…The pathogenesis of RAS involves activation of T lymphocytes through cell-mediated immunity. Tumour necrosis factor-α along with other cytokines cause epithelial cell death and aphthous ulceration [8,9]. There is no definitive treatment available for RAS [2].…”

Section: Introductionmentioning

confidence: 99%

“…There is no definitive treatment available for RAS [2]. Brocklehurst P, et al [8] in their analysis about systemic interventions for RAS found that no single treatment was effective. The interventions were grouped as immunomodulatory/anti-inflammatory and uncertain [8].…”

Section: Introductionmentioning

confidence: 99%

“…Brocklehurst P, et al [8] in their analysis about systemic interventions for RAS found that no single treatment was effective. The interventions were grouped as immunomodulatory/anti-inflammatory and uncertain [8]. Medications used for RAS aimed primarily to relieves symptoms, suppress the local immune response and prevents secondary infection [2,9].…”

Section: Introductionmentioning

confidence: 99%

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Traditional methods used by patients for the management of recurrent aphthous stomatitis.

Hegde¹,

Ajila²,

Babu³

et al. 2017

J Intercult Ethnopharmacol

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Aim: Recurrent aphthous stomatitis (RAS) is the most common ulcerative condition of oral mucosa. Due to the lack of curative treatment in RAS, patients seek conventional and alternative treatments. Data regarding alternative treatments for RAS used by Indian population is lacking. Hence, the purpose of our study was to determine and describe the various traditional modalities used by patients with RAS. Methods: Present study was carried out in patients visiting dental hospital from 2015-2016. Detailed case history recording and clinical examination was done by trained professionals. Patients diagnosed with RAS were recruited in our study. Questionnaire was given for RAS patients and data obtained was analysed. Results: A total of 326 patients reported with RAS. The study sample consisted of 171 females (52.5%) and 155 males (47.5%). In our study 198 subjects (60.7%) gave history of receiving treatment and 128 subjects (39.3 %) did not receive any kind of treatment. Out of the 198 subjects, 63 (31.8%) of individuals received conventional treatment, alternative treatments were opted by 85 (43%) patients and combined treatment modalities were opted by 50 (25.2%) patients. Over the counter medications were used by 36 (18%) patients. Treatment outcome was satisfactory according to 137 (69%) individuals and treatment was not satisfactory for 61 (31%) patients. Conclusion: This study gives insight into the various traditional medicines used in south India for RAS and to the best of our knowledge, this is first study which describes the same. Our study adds new information to the current literature about traditional medications for RAS.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Traditional methods used by patients for the management of recurrent aphthous stomatitis.

Hegde¹,

Ajila²,

Babu³

et al. 2017

J Intercult Ethnopharmacol

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“…Brocklehurst et al 30 Determinar o efeito clínico de intervenções sistêmicas na redução da dor associada a úlcera aftosa recorrente em episódios duradouros ou frequentes.…”

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Tratamento da estomatite aftosa recorrente: uma revisão integrativa da literatura

Vieira

Carmo

Vieira

et al. 2016

Rev. da Fac. de Odontologia, UPF

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IntroduçãoA estomatite aftosa recorrente (EAR) é uma condição comum caracterizada por úlceras múltiplas, pequenas, ovoides, com margem circunscrita, halo eritematoso e fundo amarelo ou cinza, com aparecimento típico primeiramente na infância ou adolescência 1 . A manifestação dessa alteração dá-se em surtos e com um curso crônico, com tempo limitado da lesão, na maior parte dos casos 2,3 . Do ponto de vista epidemiológico, a EAR é uma das mais comuns desordens orais, conhecida por afetar cerca de 20% da população em algum momento da vida 4 . Apesar de sua alta prevalência na população, sua etiopatogenia perdura como um enigma, pois, mesmo com muitas investigações, os estudos têm falhado em encontrar a sua exata etiologia

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Common Oral Conditions

Stoopler,

Villa,

Bindakhil

et al. 2024

JAMA

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ImportanceDry mouth, oral candidiasis, and recurrent aphthous ulcers are 3 of the most common oral conditions that may be associated with patient discomfort, decreased quality of life, and morbidity.ObservationsIn a meta-analysis of 26 population-based cohort and cross-sectional studies, the global prevalence of dry mouth symptoms was 23% (95% CI, 18% to 28%), placing individuals at risk of oral candidiasis, dental caries, dysgeusia, masticatory/speech impairment, and oropharyngeal dysphagia. Dry mouth is associated with using more than 3 oral medications per day (odds ratio [OR], 2.9 [95% CI, 1.4 to 6.2]), head and neck radiation, and Sjögren disease. Symptoms may include difficulty swallowing and speaking, thirst, and halitosis. Dry mouth is associated with an 11.5% (95% CI, 3.6% to 27%) higher risk of oral candidiasis, based on a meta-analysis of 6 observational cohorts. Management of dry mouth includes mechanical salivary stimulants, oral moisturizers, and/or systemic sialagogues. Oral candidiasis is an opportunistic fungal infection caused by overgrowth of the Candida genus with C albicans, which accounts for 76.8% of infections. The prevalence of oral candidiasis is higher in patients who are immunosuppressed, for example, those with HIV (35% [95% CI, 28% to 42%]) and those with salivary gland hypofunction (OR, 3.02 [95% CI, 1.73 to 5.28]). Common risk factors associated with oral candidiasis include use of antibiotics (P = .04) and oral mucosal disorders such as lichen planus. Oral burning and dysgeusia are common symptoms of oral candidiasis. Treatment includes addressing risk factors and use of topical and/or systemic antifungal medications. Recurrent aphthous stomatitis is characterized by symptomatic round or oval oral ulcers, which are covered by a gray-white fibrin layer and encircled by an erythematous ring. A meta-analysis of 10 case-controlled studies revealed an increased risk of recurrent aphthous stomatitis associated with polymorphism of IL-1β (+3954C/T) (OR, 1.52 [95% CI, 1.07 to 2.17]) and IL-1β (−511C/T) (OR, 1.35 [95% CI, 1.09 to 1.67]). Another meta-analysis of 9 case-control studies reported that patients with recurrent aphthous stomatitis had a higher frequency of nutritional deficiencies, including vitamin B12 (OR, 3.75 [95% CI, 2.38 to 5.94]), folic acid (OR, 7.55 [95% CI, 3.91 to 14.60]), and ferritin (OR, 2.62 [95% CI, 1.69 to 4.06]). Recurrent aphthous stomatitis can be associated with systemic diseases. A meta-analysis of 21 case-control studies revealed that celiac disease is associated with a higher incidence of recurrent aphthous stomatitis (25% vs 11%; OR, 3.79 [95% CI, 2.67 to 5.39]; P &lt;.001). Topical corticosteroids are first-line agents to manage recurrent aphthous stomatitis; however, systemic medications may be necessary in more severe cases.Conclusions and RelevanceDry mouth, oral candidiasis, and recurrent aphthous ulcers are common oral conditions that may be associated with patient discomfort, decreased quality of life, and morbidity. First-line treatment includes over-the-counter sialagogues for dry mouth, topical antifungals for oral candidiasis, and topical corticosteroids for aphthous ulcers. Oral conditions that do not improve with first-line treatment may require treatment with systemic medications.

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Systemic interventions for recurrent aphthous stomatitis (mouth ulcers)

Cited by 85 publications

References 48 publications

Traditional methods used by patients for the management of recurrent aphthous stomatitis.

Traditional methods used by patients for the management of recurrent aphthous stomatitis.

Tratamento da estomatite aftosa recorrente: uma revisão integrativa da literatura

Common Oral Conditions

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