Systemic levels of ceruloplasmin oxidase activity in allergic asthma and allergic rhinitis

Yalçın, Arzu Didem; Gümüşlü, Saadet; Parlak, Gizem Esra; Bişgin, Atıl; Yıldız, Mustafa; Kargi, Aysegul; Gorczynski, Reginald M.

doi:10.3109/08923973.2012.697902

Cited by 20 publications

(12 citation statements)

References 31 publications

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“…Our earlier studies provided a novel perspective on severe persistent allergic asthma and the effect of anti-IgE treatment, using as markers serum soluble TNF-related apoptosis-inducing ligand, total antioxidant capacity, hydrogen peroxide, malondialdehyde, ceruloplasmine oxidase activity, high sensitive C reactive protein and total nitric oxide concentrations measurements [13–16]. In our previous study we found that the TRAIL levels in variances of the patients who had the effective anti IgE treatment were significantly lower than the healthy controls [16].…”

Section: Discussionmentioning

confidence: 99%

Soluble trail as a marker of efficacy of allergen-specific immunotherapy in patients with allergic rhinoconjunctivitis

et al. 2012

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SummaryBackgroundAllergic rhinitis is a common health problem affecting the immune system. The homeostasis of the immune system is regulated by apoptosis. In this study, serum circulating soluble TRAIL levels of allergic rhinoconjunctivitis patients before and after allergen-specific immunotherapy were evaluated.Material/MethodsThe sTRAIL levels of pre- and post-treated allergic rhinoconjunctivitis patients (n=25) were compared to age- and sex-matched healthy individuals (n=25). sTRAIL levels were measured by ELISA. The skin prick test (SPT) results were recorded before and after treatment.ResultsThe sTRAIL levels between the pre-treated and control groups were significantly different (p<0.0001). However, there was no significant difference between the post-treated group and healthy individuals (p=0,801). SPT was a statistically significant difference between the values of the research group before and after immunotherapy (grasses mixture, barley mixture, Oleaauropeae, D. Pteronyssinus, D. farinae).ConclusionsThe sTRAIL levels were decreased after allergen-specific immunotherapy to healthy levels and may be of use as a marker of efficacy of immunotherapy in allergic rhinoconjunctivitis patients.

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Section: Discussionmentioning

confidence: 99%

Soluble trail as a marker of efficacy of allergen-specific immunotherapy in patients with allergic rhinoconjunctivitis

et al. 2012

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“…The most recent studies on severe persistent allergic asthma and the effect of omalizumab treatment, provided novel perspectives on using serum soluble TNF-related apoptosis inducing ligand, nitric oxide, malondialdehyde, hydrogen peroxide and albumin levels, total antioxidant capacity and ceruloplasmin activity as an efficacy marker [33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

Omalizumab: Anti-IgE Therapy in Severe Allergic Conditions

Yalçın¹

2012

J Aller Ther

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Background: The primary use of omalizumab (trade name Xolair) is for patients with severe, persistent and allergic asthma. Our aim was to evaluate the therapeutic efficacy of omalizumab as a treatment modality in patients with different allergic conditions. Methods: There were eleven patients, whom followed-up with omalizumab therapy in the Immunology -Allergy Clinic, were evaluated by the clinical findings of nasal polyposis, anaphylaxis history, drug allergy, latex allergy, food allergy, autoimmune urticaria, allergic rhino-conjunctivitis, atopic dermatitis, angioedema and venom allergy. Results:The patients, who had severe persistent asthma for periods ranging from 3 to 8 years, were enrolled in the study. Omalizumab was chosen as a potential new systemic therapy for the patients due to the clinical indication. Clinical symptoms of the all patients with severe persistent asthma were decreased. And in addition, asthma control test and pulmonary function tests were improved up. A severe anaphylactic reaction is prevented in a patient with 48 bee stings. Conclusion:This clinical follow-up of omalizumab treated patients with severe persistent asthma and many different allergic conditions, suggests omalizumab is an effective therapy for asthma and different allergic conditions.

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“…Many studies have suggested markers which will enable us to monitor clinical improvement. Our earlier studies provided a novel perspective on allergic asthma and the effect of anti IgE treatment, using as markers serum soluble TNF-related apoptosis-inducing ligand, total antioxidant capacity, hydrogen peroxide, malondialdehyde total nitric oxide concentrations and ceruloplasmin oxidase activity measurements [29][30][31][32]. Taken together, our results and those of others suggest that characterization of the specific receptor systems activated, and the pro-inflammatory factors regulated, by TRAIL in vivo may lead to the development of novel therapeutic strategies for diseases as diverse as allergy [29,33].…”

Section: Discussionmentioning

confidence: 99%

The Incidence of the Epidemiological Markers of Allergy in Adults

Yalçın¹

2014

Ann Clin Anal Med

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were recorded. Results: Total Ig E level was 307.6 ± 14.5 kU/L. Age of 25.6 % of the patients was between 30-39 years. The most common irritant that exacerbates the allergic rhinitis and asthma symptoms was air pollution (%77.0) and house dust ranks second (%76.2). The SPT of the cases were evaluated taking the age groups into account and this revealed an decreased rate of positivity to the prick test for plants and cereals with increasing age (p<0.001). Among smokers grass, mold ,epidermal prick positivity was significant. Discussion: In allergic diseases; allergens may have regional variations.That's why; the allergen profiles of the regions must be determined and the dermal Prick tests must be prepared accordingly.

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Systemic levels of ceruloplasmin oxidase activity in allergic asthma and allergic rhinitis

Cited by 20 publications

References 31 publications

Soluble trail as a marker of efficacy of allergen-specific immunotherapy in patients with allergic rhinoconjunctivitis

Soluble trail as a marker of efficacy of allergen-specific immunotherapy in patients with allergic rhinoconjunctivitis

Omalizumab: Anti-IgE Therapy in Severe Allergic Conditions

The Incidence of the Epidemiological Markers of Allergy in Adults

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