Systemic low-grade inflammation is related to both circulating and adipose tissue TNFα, leptin and IL-6 levels in obese women

Maachi, Mustapha; Piéroni, Laurence; Bruckert, Éric; Jardel, Claude; Fellahi, Soraya; Hainque, Bernard; Capeau, Jacqueline; Bastard, J.-P.

doi:10.1038/sj.ijo.0802718

Cited by 336 publications

(273 citation statements)

References 34 publications

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“…Both IL-6 and TNF-a activate CRP production. 83,85 Reduction of fat mass is directly associated with reductions in the inflammatory adipokines, as much as 20% depending on the degree of weight loss in both animals and humans. 79,86 Elevations of inflammatory molecules stimulate the expression of atherogenic endothelial adhesion molecules and promote the attachment and migration of monocytes into vessel walls, causing conversion of monocytes to macrophages.…”

Section: Lipids and Lipid Oxidizabilitymentioning

confidence: 99%

Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans

2005

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Objective: Oxidative stress may be the unifying mechanism underlying the development of comorbidities in obesity. Evidence suggests that a clustering of sources of oxidative stress exists in obesity: hyperglycemia, hyperleptinemia, increased tissue lipid levels, inadequate antioxidant defenses, increased rates of free radical formation, enzymatic sources within the endothelium, and chronic inflammation. Method: This review provides a summary of the available evidence on systemic oxidative stress in humans and specific metabolic pathways by which obesity may elevate systemic oxidant stress. The authors suggest possible methods of reducing oxidative stress such as antioxidant supplementation, caloric restriction and/or physical activity and surgical intervention to combat free radicals and reduce adipose tissue. Results: Obesity is associated with oxidative stress and can be reduced with weight loss (regardless of exercise or surgery induced weight loss), caloric restriction or antioxidant rich diets. Conclusion: Oxidative stress levels are elevated in human obesity, and these levels are modifiable with various lifestyle modifications and surgical interventions.

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Section: Lipids and Lipid Oxidizabilitymentioning

confidence: 99%

Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans

2005

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“…[1][2][3][4] Adipocytokines such as TNFa or IL-6 are generally elevated with increasing adiposity, 5,6 and are closely correlated with CRP, 7 a known inflammatory marker. 8 These inflammatory adipocytokines are considered to play an important role in the development of metabolic complications in obesity.…”

Section: Introductionmentioning

confidence: 99%

Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters

et al. 2006

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Background: Chemotactic cytokines, referred to as chemokines, play an important role in leukocyte trafficking. The circulating levels of chemokines have been shown to increase in inflammatory processes including obesity-related pathologies (e.g. atherosclerosis and diabetes). However, little is currently known about the relationship between chemokines and human obesity. In the present study, we investigated the circulating levels of selected chemokines (monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1a (MIP-1a), leukotactin-1, interleukin-8 (IL-8)) and the association between the chemokine levels and obesity-related parameters: body mass index (BMI), waist circumference, fasting glucose and insulin levels, lipids profile, and the level of C-reactive protein (CRP). Methods: A total of 100 subjects, 50 obese (BMIX25 kg/m 2 ) and 50 who were not obese (BMIo25 kg/m 2 ) participated in the present study. The levels of chemokines and CRP were measured in a fasting state serum by sandwich enzyme-linked immunosorbent assay. Total cholesterol, high-density lipoprotein (HDL)-cholesterol, triglyceride, glucose, and insulin levels were measured by enzymatic analysis and immunoassay. Results: The circulating levels of MCP-1 and IL-8 in the serum were significantly (Po0.05) higher in obese subjects (BMI430 kg/ m 2 ) compared with those of nonobese controls (BMIo25 kg/m 2 ). The levels of CRP were positively correlated with BMI (Po0.001) or waist circumference (Po0.0001). The levels of MCP-1 and IL-8 were positively related to BMI (MCP-1, Po0.02; IL-8, Po0.01) and/or waist circumference (MCP-1, Po0.009; IL-8, Po0.03). The levels of MCP-1 were positively related to the levels of CRP (Po0.007) or interleukin-6 (IL-6) (Po0.0001), and negatively related to the levels of HDL-cholesterol (Po0.01). Homeostasis model assessment (HOMA) score was positively related to the levels of MCP-1 (Po0.02) or IL-8 (Po0.03) in obese subject. Discussion: Our data demonstrated that the circulating levels of MCP-1 and IL-8 are related to obesity-related parameters such as BMI, waist circumference, CRP, IL-6, HOMA and HDL-cholesterol. These findings suggest that the circulating MCP-1 and/or IL-8 may be a potential candidate linking obesity with obesity-related metabolic complications such as atherosclerosis and diabetes.

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“…Population studies have shown strong associations between indices of inflammation, abnormal lipid and carbohydrate metabolism, obesity and insulin resistance [4][5][6][7][8]. In a cross-sectional study of 822 young men and women [5], obesity was independently related to Creactive protein (CRP), with a 3-7% increase in mean CRP levels for each unit (kg/m 2 ) increase in BMI.…”

Section: Introductionmentioning

confidence: 99%

“…Several adipokines act either as independent risk factors, or as combined risk factors. A strong positive correlation between both circulating and adipose tissue levels of TNF-α, leptin and high-sensitivity CRP (hs-CRP) levels has been reported, but these correlations disappeared when adjusted for fat mass [8]. The authors concluded that there is a strong relationship between adipocytokines and inflammatory markers, suggesting that cytokines secreted by adipose tissue in obese subjects play a role in the increased secretion of inflammatory proteins by the liver.…”

Section: Introductionmentioning

confidence: 99%