Systemic Lupus Erythematosus

Tselios, Konstantinos; Urowitz, Murray B.

doi:10.1016/b978-0-12-803267-1.00010-7

Cited by 3 publications

(9 citation statements)

References 279 publications

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“…Vascular imaging has been used in the general population to assess for atherosclerotic burden [26]. Carotid ultrasound with IMT and carotid plaque has been shown to independently predict CVEs.…”

Section: The Role Of Imaging Modalities In Atherosclerosis In Slementioning

confidence: 99%

“…Carotid ultrasound with IMT and carotid plaque has been shown to independently predict CVEs. Various other imaging modalities have shown benefit in the general population, with yet unclear clinical value in the setting of SLE [26].…”

Section: The Role Of Imaging Modalities In Atherosclerosis In Slementioning

confidence: 99%

“…Pulse-wave velocity (PWV): PWV analysis and the derivative variable augmentation index are surrogate measure of arterial stiffness, which occurs in the next stage of atherosclerosis [26,65]. These are independent predictors of CVEs in the general population.…”

Section: The Role Of Imaging Modalities In Atherosclerosis In Slementioning

confidence: 99%

“…Elevated homocysteine levels increase oxidative stress and inhibition of endothelial derived nitric oxide synthetase, causing endothelial dysfunction. Homocysteine may also induce a prothrombotic state by impairing the function of platelets and soluble coagulation factors [26].…”

Section: Introductionmentioning

confidence: 99%

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Accelerated Atherosclerosis in SLE: Mechanisms, Consequences, and Future Directions

Semalulu¹,

Tselios²

2023

Systemic Lupus Erythematosus - Pathogenesis and Management

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The bimodal mortality rate in systemic lupus erythematosus (SLE) has been well documented, with atherosclerosis identified as a leading cause of late-stage death. Multiple mechanisms are responsible for accelerated atherosclerosis in SLE, ultimately resulting in endothelial dysfunction, arterial stiffness, arterial wall thickening, and plaque formation. This leads to an increased risk of coronary artery disease, cardiovascular events, cerebrovascular accidents, and peripheral arterial disease. SLE patients are not only impacted by traditional risk factors for cardiovascular disease (age, smoking, dyslipidemia, diabetes), but additionally nontraditional risk factors (prolonged corticosteroid use, disease activity and chronic inflammation). Identifying the impact of traditional risk factors and mediating nontraditional risk factors in SLE are vital to reduce morbidity and mortality related to atherosclerosis. SLE-specific screening methods should be established in the routine care of these patients, including the use of validated modified risk scores and imaging modalities. Furthermore, the utility of disease-specific biomarkers and anti-atherosclerotic therapies should be elicited. This chapter will provide an overview of considerations for the mechanisms, impact, and prevention of atherosclerosis in SLE patients.

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Section: The Role Of Imaging Modalities In Atherosclerosis In Slementioning

confidence: 99%

Section: The Role Of Imaging Modalities In Atherosclerosis In Slementioning

confidence: 99%

Section: The Role Of Imaging Modalities In Atherosclerosis In Slementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Accelerated Atherosclerosis in SLE: Mechanisms, Consequences, and Future Directions

Semalulu¹,

Tselios²

2023

Systemic Lupus Erythematosus - Pathogenesis and Management

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“…Its prevalence is estimated to be around 15-50 per 100,000 individuals with a female predilection [1]. Cardiopulmonary manifestations are common in SLE, often in the form of serositis, and include pleural and pericardial effusion [2]. Pleuropulmonary manifestations occur in nearly half of SLE patients throughout the disease and may present in 4-5% of SLE patients.…”

mentioning

confidence: 99%

Detecting jellyfish sign in a patient with systemic lupus erythematosus: An added value of the echocardiography

Menaisy¹

2021

Indian J Case Reports

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Systemic lupus erythematosus (SLE) is an autoimmune disease that affects nearly every organ of the body. Cardiopulmonary manifestations are common in SLE, almost in the form of serositis, and include pleural and pericardial effusions. In these patients, echocardiography is an excellent non-invasive tool for detecting pericardial effusion and may provide a hint about pleural effusion. We report the case of a 20-year-old woman with SLE who had been experiencing dyspnea for 1 month and had no prior history of cardiovascular or pulmonary disease. A rheumatologist referred her to our echocardiography lab for a cardiac evaluation. In the echocardiographic examination, pleural mass depended from the left visceral pleura was discovered, surrounded by massive pleural effusion that induced left lung atelectasis (Jellyfish sign, and complete atelectasis of a lung lobe floats above a massive pleural effusion).

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Evaluation of MicroRNA-451a Expression in Lupus Nephritis

Hananto,

Christiani,

Sari

et al. 2023

Indonesian J. Clin. Pathol. Med. Lab.

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The pathogenesis of Lupus Nephritis (LN) is still unclear, causing difficulties in diagnosis and therapeutic management. Recent studies have suggested that microRNAs (miRNAs) may play an important role in the pathogenesis of LN. However, the role of miRNA-451a in LN has not been widely studied and known, and there is controversy in the results of studies that have been done. This study aimed to analyze the expression of miRNA-451a in LN and lupus without nephritis and to evaluate its correlation with hemoglobin levels, leukocyte count, leukocyturia, and erythrocyturia. Samples from 45 lupus participants were collected, consisting of 22 with LN and 23 without nephritis. The expression of microRNA 451a was determined by reverse transcriptase real-time PCR. Renal disorder criteria based on ACR criteria. Statistical analysis using Mann-Whitney, Spearman correlation, ROC curve, and table 2X2. MiRNA-451a expression in LN (median 0.31; range 0.06-7.21) was lower than in lupus without nephritis (median 1.31; range 0.07-13.26) with a significant difference (p=0.041). The cut-off value for comparing the two groups was 0.7531 with an accuracy of 75%. The correlation between miRNA 451a expression and hemoglobin levels, blood leukocyte count, erythrocyturia, and leukocyturia showed no significant correlation (p > 0.05). MicroRNA-451a expression in lupus nephritis was lower than in lupus without nephritis.

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Systemic Lupus Erythematosus

Cited by 3 publications

References 279 publications

Accelerated Atherosclerosis in SLE: Mechanisms, Consequences, and Future Directions

Accelerated Atherosclerosis in SLE: Mechanisms, Consequences, and Future Directions

Detecting jellyfish sign in a patient with systemic lupus erythematosus: An added value of the echocardiography

Evaluation of MicroRNA-451a Expression in Lupus Nephritis

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