Systemic lupus erythematosus: a systematic review with meta-analysis on muscle strength, muscle mass, and physical function

Pena, Émerson; Santos, Leonardo Peterson dos; Santo, Rafaela Cavalheiro do Espírito; Guaresi, Silvia; Hirakata, Vânia Naomi; Karnopp, Thaís Evelyn; Xavier, Ricardo Machado; Monticielo, Odirlei André

doi:10.1007/s10067-023-06516-9

Cited by 6 publications

(2 citation statements)

References 42 publications

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“…In this meta-analysis, HGS in patients with lupus was calculated to be 21.74 kg. 8 The muscle strength in patients with SLE in our study was similar (21.7±4.9) and was found to be significantly lower than in the healthy control group. Our data show a higher prevalence of probable sarcopenia and sarcopenia in patients with SLE than expected for this age group.…”

Section: Diṡcussiȯnsupporting

confidence: 70%

Frequency of sarcopenia in Turkish women with systemic lupus erythematosus

Bilici,

Candemir,

Satış

et al. 2024

Lupus Sci Med

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ObjectiveThis study aimed to evaluate the prevalence of sarcopenia and its clinical significance in Turkish women with SLE, exploring the association between muscle mass, muscle strength and SLE disease activity.MethodsA cross-sectional study was conducted at Gazi University Hospital’s Department of Rheumatology from January to December 2020. It involved 82 patients with SLE, diagnosed according to the 2019 American College of Rheumatology/European Alliance of Associations for Rheumatology criteria, and 69 healthy controls. Sarcopenia was assessed using hand grip dynamometry (hand grip strength (HGS)) and bioelectrical impedance analysis for muscle mass, with sarcopenia defined according to the 2018 European Working Group on Sarcopenia in Older People criteria and specific cut-offs for the Turkish population. The main outcomes measured were the presence of sarcopenia and probable sarcopenia, HGS values, skeletal muscle mass index and SLE Disease Activity Index 2000 (SLEDAI-2K).ResultsAmong the patients with SLE, 51.2% met the criteria for probable sarcopenia and 12.9% were diagnosed with sarcopenia. The mean HGS was significantly lower in the SLE group (21.7±4.9 kg) compared with controls, indicating reduced muscle strength. The prevalence of anti-double-stranded DNA (anti-dsDNA) antibodies was 82.9%. Multivariate regression analysis identified height and levels of anti-dsDNA antibodies as independent predictors for developing probable sarcopenia. No significant association was found between clinical parameters, including SLEDAI-2K scores, and sarcopenia status.ConclusionsSarcopenia is prevalent among Turkish women with SLE, with a significant proportion showing reduced muscle strength. The study found no direct association between sarcopenia and SLE disease activity or clinical parameters. These findings underscore the importance of including muscle strength assessments in the routine clinical evaluation of patients with SLE to potentially improve management and quality of life.

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Section: Diṡcussiȯnsupporting

confidence: 70%

Frequency of sarcopenia in Turkish women with systemic lupus erythematosus

Bilici,

Candemir,

Satış

et al. 2024

Lupus Sci Med

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“…2 3 Hand grip strength, a component of the Fried phenotype, has been proposed as a proxy for health status in the general population. 4 Weaker hand grip strength has been observed in adults with SLE relative to non-SLE comparators, 5 and weaker hand grip is associated with higher cardiometabolic risk when adjusted for body mass index (BMI). 6 Telomeres consist of repetitive DNA sequences and protein complexes that protect chromosomes from damage and rearrangement.…”

Section: Introductionmentioning

confidence: 99%

Association of phenotypic frailty and hand grip strength with telomere length in SLE

Lieber,

Lipschultz,

Syed

et al. 2024

Lupus Sci Med

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ObjectiveFrailty and objective hand grip strength (one of the components of the frailty phenotype) are both risk factors for worse health outcomes in SLE. Whether telomere length, an established cellular senescence marker, is a biologic correlate of the frailty phenotype and hand grip strength in patients with SLE is not clear. First, we aimed to evaluate differences in telomere length between frail and non-frail women with SLE and then assessed whether frailty or hand grip strength is differentially associated with telomere length after adjusting for relevant confounders.MethodsWomen ≥18 years of age with validated SLE enrolled at a single medical centre. Fried frailty status (which includes hand grip strength), clinical characteristics and telomere length were assessed cross-sectionally. Differences between frail and non-frail participants were evaluated using Fisher’s exact or Wilcoxon rank-sum tests. The associations between frailty and hand grip strength and telomere length were determined using linear regression.ResultsOf the 150 enrolled participants, 131 had sufficient data for determination of frailty classification; 26% were frail with a median age of 45 years. There was a non-significant trend towards shorter telomere length in frail versus non-frail participants (p=0.07). Hand grip strength was significantly associated with telomere length (beta coefficient 0.02, 95% CI 0.004, 0.04), including after adjustment for age, SLE disease activity and organ damage, and comorbidity (beta coefficient 0.02, 95% CI 0.002, 0.04).ConclusionsDecreased hand grip strength, but not frailty, was independently associated with shortened telomere length in a cohort of non-elderly women with SLE. Frailty in this middle-aged cohort may be multifactorial rather than strictly a manifestation of accelerated ageing.

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