Systemic lupus erythematosus and gouty arthritis: an uncommon association

Bajaj, Sonia; Fessler, Barri J.; Alarcón, Graciela S.

doi:10.1093/rheumatology/keh043

Cited by 18 publications

(16 citation statements)

References 22 publications

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“…The significance and independence of serum UA levels were confirmed by a multivariate analysis, involving variables affecting serum UA levels and probable PH‐associated factors. This association is compelling since hyperuricemia is not usually observed in SLE patients except in the case of renal insufficiency and in use of drugs, such as diuretics . Then, what are the the mechanism(s) by which an increased UA is observed in SLE patients with PH?…”

Section: Discussionmentioning

confidence: 99%

High levels of uric acid in systemic lupus erythematosus is associated with pulmonary hypertension

et al. 2014

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Aim: To estimate the point prevalence of pulmonary hypertension (PH) and determine the associated factors for PH in patients with systemic lupus erythematosus (SLE).Methods: A prospective cross-sectional study of 114 patients with SLE was conducted in a single tertiary center. Transthoracic echocardiography was performed to estimate the pulmonary arterial pressures. PH was defined as resting systolic pulmonary artery pressure (sPAP) ≥ 40 mmHg, in the absence of left heart disease.Results: PH was identified in nine patients (7.9%) who had few cardiopulmonary symptoms. SLE patients with PH had higher SLE disease activity index score. In particular, serum uric acid (UA) was significantly higher in patients with PH than in those without PH. In multivariate analysis, UA remained significant for the presence of PH. Moreover, serum UA level correlated significantly with plasma NT-pro-B-type natriuretic peptide level as well as sPAP. At the cutoff level of 6.5 mg/dL, serum UA had reasonable accuracy for predicting the presence of PH in SLE patients (sensitivity 66.7% and specificity 96.2%).Conclusion: A significant number of SLE patients in rheumatology practice have undiagnosed PH with few discernible symptoms. Serum UA level may be useful as a surrogate marker for screening of PH in patients with SLE.

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Section: Discussionmentioning

confidence: 99%

High levels of uric acid in systemic lupus erythematosus is associated with pulmonary hypertension

et al. 2014

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“…Gut ve diğer romatizmal hastalıkların birlikteliği nadirdir; romatoid artrit ve gut birlikteliği ise çok nadir gözlenir. 4,5 Gutun eşlik edebildiği hastalıklar içinde sistemik lupus eritematozus ve sistemik skleroz yer almaktadır. [4][5][6] Ancak insidansa dair kesin bir veri yoktur.…”

Section: Discussionunclassified

“…2,3 Gut hastalığı skleroderma, romatoid artrit, sistemik lupus eritematozus gibi farklı romatolojik hastalıklarla birlikte de gözlenebilmektedir. [4][5][6][7] Literatür gözden geçirildiğinde, AS ve gut birlikteliğine dair az sayıda yayın vardır. [8][9][10] Bu çalışmada, AS tanısı ile uzun süredir takip edilen; akut periferik artritle başvurarak eşlik eden gut artriti tanısı alan bir olgu sunulmuştur.…”

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The Importance of Differential Diagnosis in Patients with Ankylosing Spondylitis Presenting with Acute Peripheral Arthritis

Yilmaz¹

2020

J PMR Sci

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“…This association is compelling since hyperuricemia is not usually observed in SLE patients except in the case of renal insufficiency and in use of drugs, such as diuretics (22). Then, what are the mechanism(s) by which an increased UA is observed in SLE patients with PH?…”

Section: Sle Is An Autoimmune Disorder Characterized By Multisystem Imentioning

confidence: 99%

Study Of Serum Uric Acid Level In patients With Systemic Lupus Erythematosus

Hemida¹,

Khalil²,

Gaber³

2017

Int. J. Curr. Res. Med. Sci.

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Background: Pulmonary Hypertension (PH) is a serious and often fatal complication of systemic lupus erythematosus (SLE). Because the diagnosis of PH often is made years after symptom onset, early diagnostic strategies are essential. Serum uric acid ( U A ) currently is considered a marker for screening of PH in patients with SLE . Aim :To study the association between PH and serum uric acid in SLE patients and the possibility of using serum uric acid as a surrogate marker for screening of PH in patients with SLE. Patients and Methods : A Case control study was conducted on 80 subjects 60 of them were SLE patients.The included subjects were divided into 4 groups as follows : Group I: 30 SLE patients with PH , Group II : 30 SLE without PH , Group III : 10 subjects as a positive controls ( with PH ) and Group IV : 10 subjects as a negative controls ( without PH) . All patients and controls were subjected to the following : Full history taking, complete physical examination, Serum uric acid , CBC , ESR , C-reactive protein , serum creatinine , blood urea , anti-nuclear (ANA ) and anti-double-stranded DNA antibodies , anti-scleroderma 70 ( SCL-70 ) and anti ribonucleoprotein ( RNP ) antibodies , lupus anticoagulant , anti cardiolipin , b2-glycoprotein I antibodies and Doppler echocardiography . Results : serum UA levels were significantly higher in SLE patients with PH ( p-value<0.001) than in SLE patients without PH ( p-value=0.403) and than control positive group ( p-value=0.771) and than control negative group ( pvalue= 0.343) . Also there is a Positive correlation and significance between systolic pulmonary arterial pressure ( sPAP ) with uric acid in SLE patients with PH.

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Systemic lupus erythematosus and gouty arthritis: an uncommon association

Cited by 18 publications

References 22 publications

High levels of uric acid in systemic lupus erythematosus is associated with pulmonary hypertension

High levels of uric acid in systemic lupus erythematosus is associated with pulmonary hypertension

The Importance of Differential Diagnosis in Patients with Ankylosing Spondylitis Presenting with Acute Peripheral Arthritis

Study Of Serum Uric Acid Level In patients With Systemic Lupus Erythematosus

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