Systemic lupus erythematosus and hypertension

Coptisine Alleviates Pristane-Induced Lupus-Like Disease and Associated Kidney and Cardiovascular Complications in Mice

“…Another primary cause of mortality in SLE, particularly in women who survive beyond the first 5 years, is cardiovascular disease (Manzi et al, 1997). Numerous studies have reported that hypertension is common among patients with SLE, and studies have shown that it is more prevalent in SLE patients than in people without SLE (Munguia-Realpozo et al, 2019). In this study, blood pressure was monitored during the experiment, and the data showed that coptisine reduced blood pressure.…”

“…In addition to prominent renal disease, another primary cause of mortality in SLE is cardiovascular disease. Studies have reported that women with SLE are at a 50-fold greater risk for developing cardiovascular disease independent of traditional Framingham Heart Study risk factors (Munguia-Realpozo et al, 2019). To date, existing common therapies for SLE, namely, corticosteroids and anti-malarial and various immunosuppressive agents, despite being effective in suppressing disease progression, rarely offer long-term remission; moreover, medicationrelated toxicity contributes to morbidity and mortality, and existing drugs have little effect on kidney and cardiovascular complications.…”

Effect of Hypertension on Childhood-onset Systemic Lupus Erythematous in a Tertiary Medical Center in Korea

“…Despite the high frequency of hypertension in SLE pati ents, the pathophysiological mechanisms underlying the development of hypertension in this population remain poorly understood. Although renal glomerular damage and renal vascular endothelial dysfunction have been hy pothesized to be the main contributors, hypertension is also present in SLE patients without renal involvement 5) . Many possible mechanisms such as reninangiotensin aldosterone system activation, dysautonomia, immune complex deposits in tissues, the effect of inflammatory mediators, and antiinflammatory therapy have been pro posed to explain hypertension in SLE patients 5) .…”

“…Although renal glomerular damage and renal vascular endothelial dysfunction have been hy pothesized to be the main contributors, hypertension is also present in SLE patients without renal involvement 5) . Many possible mechanisms such as reninangiotensin aldosterone system activation, dysautonomia, immune complex deposits in tissues, the effect of inflammatory mediators, and antiinflammatory therapy have been pro posed to explain hypertension in SLE patients 5) . In addition to these wellknown mechanisms, Sabio JM et al reported that elevated homocysteine levels could increase the risk of hypertension in SLE patients 6) .…”

“…Much is known about the effects of hypertension on the SLE disease course. Several studies have demonstrated that hypertension has been associated with damage accrual, stroke, progression of renal and car diac disease, and cognitive dysfunction in SLE patients 2,5) . In adult patients with SLE, resistant hypertension was also associated with a significantly higher mortality risk 1) .…”