Systemic lupus erythematosus and microchimerism in autoimmunity

Abbud-Filho, Mário; Pavarino, Érika Cristina; Alvarenga, Maria Paula Sanches de; Fernandes, Ida Maria Maximina; Toledo, Ricardo Acayaba de; Tajara, Eloíza H.; Savoldi-Barbosa, Marcela; Goldman, Gustavo H.; Goloni-Bertollo, Eny Maria

doi:10.1016/s0041-1345(02)03501-7

Cited by 43 publications

(14 citation statements)

References 12 publications

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“…In agreement with the other two studies, we showed higher existence of DAZ among MS‐positive women given birth to a son. Our results were also similar to those reported for other autoimmune diseases in which the presence of allogenic cells has been documented (Abbud Filho et al, ; Chan et al, ; Johnson et al, ; Lambert et al, ; Mosca et al, ). In the present study, the male genome was also detected in 4 (24%) of MS‐positive women reported who had never a known pregnancy.…”

Section: Discussionsupporting

confidence: 92%

Male microchimerism in peripheral blood from women with multiple sclerosis in Isfahan Province

Jafarinia

Amoon

Javid

et al. 2019

Int J Immunogenetics

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Multiple sclerosis (MS) is referred to as an organ‐specific T‐cell‐mediated autoimmune disease of the central nervous system (CNS). Different genetic and environmental factors increase the risk of developing MS. In recent years, microchimerism (Mc) has been widely studied in autoimmune diseases, although the exact role of this phenomenon in human health is not known well. Microchimerism is the low level presence of DNA or cells from one individual into the tissue or circulation of another individual. In the current study, we evaluated the association of fetal microchimerism (FMc) with MS in Isfahan province. In this study, we enrolled 68 women in four groups. Two groups were MS patients with or without a pregnancy for a son, and the other two groups were MS‐negative patients with or without a pregnancy for a son. The presence of the male genome assessed and compared in these groups. Four millilitres of peripheral blood were collected from all subjects in the tube containing EDTA and DNA was extracted. Real‐time PCR assay was used for the DAZ (deleted in azoospermia) region Yq 11.23 as a marker for male microchimerism in all subjects. Our results showed that the percentage of DAZ (male genome)‐positive women was significantly higher in MS‐positive women given birth to a son in comparison with the other three groups. Our results also revealed no significant correlation between the percentage of DAZ‐positive women and Expanded Disability Status Scale (EDSS) score and age of onset in the patients’ group. For future studies, we suggest enrolling subjects who MS diagnosis occurred before and after pregnancy with a son. Comparing FMc in these two groups might provide a better understanding of the possible role of FMc in later development of MS.

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Section: Discussionsupporting

confidence: 92%

Male microchimerism in peripheral blood from women with multiple sclerosis in Isfahan Province

Jafarinia

Amoon

Javid

et al. 2019

Int J Immunogenetics

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“…A role for FMc in systemic lupus erythematosus has also been controversial (Abbud Filho et al 2002; Khosrotehrani et al 2005), although several studies suggest that lupus nephritis in particular is associated with an increased concentration of FMc in circulation and in renal tissue (Mosca et al 2003; Hovinga et al 2006). In a case report of an autopsy of a woman with lupus, multiple organ systems were examined, and FMc was identified in all histologically abnormal tissue, although not in healthy tissue (Johnson et al 2001).…”

Section: Fetal Microchimerismmentioning

confidence: 99%

Naturally acquired microchimerism

2010

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Bi-directional transplacental trafficking occurs routinely during the course of normal pregnancy, from fetus to mother and from mother to fetus. In addition to a variety of cell-free substances, it is now well recognized that some cells are also exchanged. Microchimerism refers to a small number of cells (or DNA) harbored by one individual that originated in a genetically different individual. While microchimerism can be the result of iatrogenic interventions such as transplantation or transfusion, by far the most common source is naturally acquired microchimerism from maternal-fetal trafficking during pregnancy. Microchimerism is a subject of much current interest for a number of reasons. During pregnancy, fetal microchimerism can be sought from the mother's blood for the purpose of prenatal diagnosis. Moreover, studies of fetal microchimerism during pregnancy may offer insight into complications of pregnancy, such as preeclampsia, as well as insights into the pathogenesis of autoimmune diseases such as rheumatoid arthritis which usually ameliorates during pregnancy. Furthermore, it is now known that microchimerism persists decades later, both fetal microchimerism in women who have been pregnant and maternal microchimerism in her progeny. Investigation of the long-term consequences of fetal and maternal microchimerism is another exciting frontier of active study, with initial results pointing both to adverse and beneficial effects. This review will provide an overview of microchimerism during pregnancy and of current knowledge regarding long-term effects of naturally acquired fetal and maternal microchimerism.

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“…Microchimerism, of presumed fetal origin, has been found more frequently among SLE cases compared to controls. One study identified fetal microchimerism in 68% of SLE cases compared to 33% of controls [5]. Similarly, another study found evidence of microchimerism in 31% of cases compared to only 4% among controls [4].…”

Section: Discussionmentioning

confidence: 99%

“…Microchimerism, or the presence of a small number of cells from one individual present in another, is a natural consequence of bi-directional cellular trafficking that takes place between mother and fetus. Previous studies have found a higher prevalence of fetal microchimerism in SLE cases compared to controls [4, 5]. …”

Section: Introductionmentioning

confidence: 98%

A Child’s HLA-DRB1 genotype increases maternal risk of systemic lupus erythematosus

Cruz

Shao

Quach

et al. 2016

Journal of Autoimmunity

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Systemic lupus erythematosus (SLE) disproportionately affects women of reproductive age. During pregnancy, women are exposed to various sources of fetal material possibly constituting a significant immunologic exposure relevant to the development of SLE. The objective of this study was to investigate whether having any children who carry DRB1 alleles associated with SLE increase the risk of maternal SLE. This case-control study is based on the University of California, San Francisco Mother-Child Immunogenetic Study and from studies at the Inova Translational Medicine Institute. Analyses were conducted using data for 1,304 mothers (219 cases/1,085 controls) and their respective 1,664 children. We selected alleles based on their known association with risk of SLE (DRB1*03:01, *15:01, or *08:01) or Epstein-Barr virus (EBV) glycoproteins (*04:01) due to the established EBV association with SLE risk. We used logistic regression models to estimate odds ratios (OR) and 95% confidence intervals (CI) for each allele of interest, taking into account maternal genotype and number of live births. We found an increase in risk of maternal SLE associated with exposure to children who inherited DRB1*04:01 from their father (OR 1.9; 95% CI, 1.1-3.2), among *04:01 allele-negative mothers. Increased risk was only present among mothers who were positive for one or more SLE risk-associated alleles (*03:01, *15:01 and/or *08:01). We did not find increased risk of maternal SLE associated with any other tested allele. These findings support the hypothesis that a child's alleles inherited from the father influence a mother's subsequent risk of SLE.

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Systemic lupus erythematosus and microchimerism in autoimmunity

Cited by 43 publications

References 12 publications

Male microchimerism in peripheral blood from women with multiple sclerosis in Isfahan Province

Male microchimerism in peripheral blood from women with multiple sclerosis in Isfahan Province

Naturally acquired microchimerism

A Child’s HLA-DRB1 genotype increases maternal risk of systemic lupus erythematosus

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