Systemic Lupus Erythematosus and the Eye

Cunningham, Emmett T.; Tabbara, Khalid F.; Zierhut, Manfred

doi:10.1080/09273948.2018.1539589

Cited by 10 publications

(6 citation statements)

References 26 publications

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“…Keratoconjunctivitis sicca is the most common ocular manifestation of SLE, followed by retinitis, scleritis, and episcleritis [ 6 ]. Retinal vasculitis is caused by thromboses of the retinal arterioles due to deposition of immune complexes and inflammation [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Bilateral Retinal Vasculitis as the First Presentation of Systemic Lupus Erythematosus

et al. 2021

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Patient: Female, 14-year-old Final Diagnosis: Retinal vasculitis Symptoms: Itchy eyes Medication: — Clinical Procedure: — Specialty: Rheumatology Objective: Unusual clinical course Background: Systemic lupus erythematosus (SLE) can involve any part of the eye. Keratoconjunctivitis sicca (dry eye) is the most common ocular manifestation, followed by scleritis, episcleritis, and retinitis. Retinal disease affects around 10% of patients with SLE. Mild retinopathy may be asymptomatic. However, severe cases can cause visual loss requiring urgent ophthalmic evaluation. Case Report: We present a case of bilateral retinal vasculitis as the presenting manifestation of SLE. A 14-year-old girl with a history of schizophrenia presented to the emergency department (ED) with generalized weakness. Four days before her presentation, she developed itching in her eyes and frontal headaches. In the ED, she reported blurry vision in her left eye only and diffuse arthralgia. The ophthalmic evaluation showed bilateral reduced visual acuity, worse in the left eye. Both eyes had diffuse hemorrhages, white retinal lesions, and blurred optic disc margins. She was diagnosed with panuveitis and retinal vasculitis. The patient was then found to have SLE, diagnosed by the presence of arthralgias, panuveitis, severe bilateral retinal vasculitis, positive ANA and anti-dsDNA, and normocytic anemia. The patient received intravenous methylprednisolone with subsequent oral prednisone upon discharge, hydroxychloroquine, and azathioprine. One year after her presentation, she had significant visual improvement and no other system involvement. Conclusions: Retinal vasculitis, as the presenting symptom of SLE, has been overlooked in large studies. However, the number of case reports documenting this as a presenting symptom, often with minimal or no organ involvement, suggests that upon diagnosis, patients might benefit from a skilled ophthalmic evaluation.

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Section: Discussionmentioning

confidence: 99%

Bilateral Retinal Vasculitis as the First Presentation of Systemic Lupus Erythematosus

et al. 2021

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“…Typische Augenmanifestationen sind 1 , 2 , 3 : Augenlidveränderungen (Plaques, erythematöse Stellen, Madarosis, Dyspigmentationen, Vernarbungen, Schwellung), orbitale Inflammation (Pseudotumor orbitae mit evtl. Myositis, klinisch Proptosis, Schmerzen, Diplopie), Keratoconjunctivitis sicca.…”

Section: Diskussionunclassified

Uveales Effusionssyndrom, Myopisierung und bilateraler sekundärer Winkelblock als Erstmanifestation eines systemischen Lupus erythematodes (SLE)

Delgadillo

Dysli

2022

Klin Monbl Augenheilkd

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Winkelblockglaukome bei PatientInnen mit asiatischer Herkunft sind relativ häufig, jedoch ist die Manifestation eines Winkelblocks im Rahmen einer systemischen Erkrankung selten. Wir präsentieren hier einen Fall einer Patientin mit bilateralem Winkelblock mit Polyserositis im Rahmen eines systemischen Lupus erythematodes. Dies ist eine idiopathische Autoimmunerkrankung, die alle Augenstrukturen betreffen kann. Bibliografie

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“…СКВ -системное аутоиммунное ревматическое заболевание неизвестной этиологии, характеризующееся гиперпродукцией органонеспецифических аутоантител к различным компонентам клеточного ядра с развитием иммуновоспалительного повреждения внутренних органов [56,57]. Поражение глаз как проявление основного заболевания выявляется у 25-50% пациентов с СКВ [58]. При СКВ описаны следующие варианты поражения глаз: ретиноваскулит, хориоидит, оптический неврит, синдром Девика (демиелинизирующий оптикомиелит), сухой кератоконьюнктивит в рамках сопутствующего синдрома Шегрена, эписклерит, склерит, кровоизлияния на сетчатке, микроаневризмы и др.…”

Section: системная красная волчанкаunclassified

Current approaches to treatment of uveitis in immune-mediated inflammatory rheumatic disease

Лисицына¹,

Alekberova²,

Давыдова

et al. 2020

Naučno-praktičeskaâ revmatologiâ

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Non-infectious uveitis is the leading and insufficiently studied cause of irreversible decline in visual functions in patients with immune-mediated inflammatory rheumatic disease (IMIRDs). A multidisciplinary approach to the diagnosis and treatment of uveitis in patients with IMIRDs, involving close collaboration of rheumatologists and ophthalmologists, is the key factor for achieving favorable clinical outcomes. This article sheds light on current clinical, differential diagnostic and therapeutic challenges related to non-infectious uveitis in IMIDs-patients, with specific emphasis on state-of-the art approaches to therapy.

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Systemic Lupus Erythematosus and the Eye

Cited by 10 publications

References 26 publications

Bilateral Retinal Vasculitis as the First Presentation of Systemic Lupus Erythematosus

Bilateral Retinal Vasculitis as the First Presentation of Systemic Lupus Erythematosus

Uveales Effusionssyndrom, Myopisierung und bilateraler sekundärer Winkelblock als Erstmanifestation eines systemischen Lupus erythematodes (SLE)

Current approaches to treatment of uveitis in immune-mediated inflammatory rheumatic disease

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