Systemic Lupus Erythematosus and Thyroid Autoimmunity

Ferrari, Silvia; Elia, Giusy; Virili, Camilla; Centanni, Marco; Antonelli, Alessandro; Fallahi, Poupak

doi:10.3389/fendo.2017.00138

Cited by 43 publications

(33 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[17][18][19] Furthermore, the most common comorbid disease in our patients was hypothyroidism; this finding is consistent with previous studies that detected a high prevalence of autoimmune thyroiditis and hypothyroidism in SLE patients. 20,21 In our survey, patients who had hypothyroidism presented with lower constitutional symptoms such as fatigue and fever, autoimmune hepatitis, depression, headache and hypertension. However, a study of Arab lupus patients revealed that those who were hypothyroid had a lower frequency of neuropsychiatric and hematologic complications but a higher frequency of polyarthritis and cutaneous manifestations compared with euthyroid individuals.…”

Section: Discussionmentioning

confidence: 83%

One-decade study of distinct features, morbidity and mortality of systemic lupus erythematosus (an update on systemic lupus erythematosus in the Fars Province of Iran)

Esmaeilzadeh

Khodamoradi

Nazarinia

2019

Lupus

View full text Add to dashboard Cite

Objective The objective of this article is to investigate the distinct features, morbidity and mortality of systemic lupus erythematosus (SLE) patients registered in rheumatology tertiary centers of Shiraz University of Medical Sciences from 2008 to 2018. Method A cross-sectional study was conducted on registered patients by reviewing their medical records. The clinical presentations were classified based on each organ’s distinct involvement. Result Data of 1322 patients with a mean age of 40 at the time of the study were reviewed. The most common primary manifestation of the disease was arthralgia (37.5%), and the most common clinical presentation in course of the disease was skin involvement (61.8%). The most common cause of hospital admission was disease flare (27.8% (108/388)), and mortality was mainly due to pulmonary complications (27.5% (8/29)). Patients who had hypothyroidism had statistically significantly lower rates of constitutional symptoms ( p = 0.006), gastrointestinal involvement ( p = 0.024), hypertension ( p = 0.002), headache ( p = 0.019), depression ( p = 0.049) and anemia ( p = 0.014). Patients who presented with malar rash and photosensitivity in their course of disease were detected to have statistically significantly lower ages of disease onset ( p = 0.013 and 0.003, respectively). Conclusion This study is an update to an epidemiologic study conducted in 2008 in the south of Iran. By comparing results between the two studies, we have tried to investigate the change in morbidity and mortality of SLE during these years.

show abstract

Section: Discussionmentioning

confidence: 83%

One-decade study of distinct features, morbidity and mortality of systemic lupus erythematosus (an update on systemic lupus erythematosus in the Fars Province of Iran)

Esmaeilzadeh

Khodamoradi

Nazarinia

2019

Lupus

View full text Add to dashboard Cite

show abstract

“…What’s more, a study published by Ferrari et al. 55 showed the high prevalence of AITDs in SLE patients, including HT and GD. Therefore, deeper studies among the correlations between SLE and HT or GD that are more meaningful for patients should be performed in the future.…”

Section: Discussionmentioning

confidence: 96%

Association between systemic lupus erythematosus and thyroid dysfunction: a meta-analysis

Luo

Mao

et al. 2018

Lupus

View full text Add to dashboard Cite

Introduction Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, the pathogenesis of which remains elusive. The deficiency or excess of thyroid hormone is defined as thyroid dysfunction, including (subclinical) hypothyroidism and (subclinical) hyperthyroidism. Autoimmune factors are likely to be relevant to the development of SLE and thyroid dysfunction. Recently, many studies have indicated that the prevalence of thyroid dysfunction is higher in SLE patients than in the general population. The objective of our study was to perform a systematic review and meta-analysis to find out the relationship between SLE and thyroid dysfunction. Methods Literature databases were searched, including PubMed, Embase, Web of science, Cochrane, CNKI, CHINESE WANFANG, China Science and Technology Database (VIP). Studies comparing presence of thyroid dysfunction in SLE patients to healthy controls were extracted. All the statistical analyses were performed with STATA 12.0 software. Results Ten studies with 10,500 SLE patients and 44,170 healthy controls were included in this study. The meta-analysis results showed that the prevalence of (subclinical) hypothyroidism in SLE patients was higher than in the healthy controls (hypothyroidism: OR = 2.93, 95% CI = 1.81–4.75; subclinical hypothyroidism: OR = 5.67, 95% CI = 3.50–9.18). No statistical difference of (subclinical) hyperthyroidism was found between SLE patients and controls. Conclusion Our meta-analysis suggests that SLE is significantly associated with increased risk of (subclinical) hypothyroidism, but it has little influence on (subclinical) hyperthyroidism.

show abstract

“…The association of HT and NEAD has been initially described by Neufeld and Blizzard and more recently reappraised by Boelaert et al (33). Among these, the most common are atrophic gastritis/pernicious anemia (34), rheumatoid arthritis (35), vitiligo (36), celiac disease (37), and systemic lupus erythematosus/APS (31,38).…”

Section: Recurrent Pregnancy Loss and Poly-autoimmunitymentioning

confidence: 99%

Recurrent Pregnancy Loss in Women with Hashimoto's Thyroiditis with Concurrent Non-Endocrine Autoimmune Disorders

Cellini

Santaguida

Stramazzo

et al. 2020

Thyroid

Self Cite

View full text Add to dashboard Cite

Background: An increased rate of recurrent miscarriage has been described in patients with autoimmune thyroid disease. However, there is a lack of studies that assess the rate of recurrent pregnancy loss (RPL) in patients with Hashimoto's thyroiditis (HT) isolated or with concurrent non-endocrine autoimmune disorders (NEAD). The objective of the study was to assess the rate of RPL in patients with HT isolated or accompanied with non-endocrine autoimmune diseases. Methods: This is a retrospective observational cohort study with a systematic review of the NEAD with concurrent HT in an outpatient Endocrinology Unit at a University Hospital. Among the 3480 consecutively examined women with HT, 87 patients met the criteria of RPL and represented the study group. Sixty-five of them had isolated HT and 22 women had HT+NEAD. Results: The rate of RPL in women with HT was 2.1% versus 5.64% observed in women with HT+NEAD (odds ratio = 2.78 [95% confidence interval 1.70-4.57]; p < 0.0001). On subdivision, this difference was still evident in euthyroid patients (p < 0.0001), while it disappeared in hypothyroid women (p = 0.21). The RPL did not correlate with the autoantibody concentrations nor in women with isolated HT nor in those with HT+NEAD. The presence of antiphospholipid syndrome (APS) explained RPL in 3 out of 22 (14%) patients with HT+NEAD, the remaining being related to different autoimmune disorders. Interestingly, even subtracting the patients with APS, RPL was more frequent in patients with poly-autoimmunity than in patients with isolated HT (p = 0.0013). Conclusions: The co-presence of NEAD is correlated with a higher risk of RPL in women with HT. The association with APS may explain only a fraction of RPL rate in patients with poly-autoimmunity.

show abstract

Systemic Lupus Erythematosus and Thyroid Autoimmunity

Cited by 43 publications

References 48 publications

One-decade study of distinct features, morbidity and mortality of systemic lupus erythematosus (an update on systemic lupus erythematosus in the Fars Province of Iran)

One-decade study of distinct features, morbidity and mortality of systemic lupus erythematosus (an update on systemic lupus erythematosus in the Fars Province of Iran)

Association between systemic lupus erythematosus and thyroid dysfunction: a meta-analysis

Recurrent Pregnancy Loss in Women with Hashimoto's Thyroiditis with Concurrent Non-Endocrine Autoimmune Disorders

Contact Info

Product

Resources

About