Systemic lupus erythematosus associated with Wells’ syndrome

Yin, Geng; Xie, Qibing

doi:10.1007/s00296-011-1809-y

Cited by 7 publications

(3 citation statements)

References 14 publications

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“…Similar histological appearances can be seen in other dermatological conditions but these can often be discriminated clinically. Wells variants have been described (El-Khalawany et al, 2013) as well as associations with other disorders affecting the skin, including connective tissue disease (Yin & Xie, 2012).…”

Section: Secondary (Reactive) Eosinophiliamentioning

confidence: 99%

Guideline for the investigation and management of eosinophilia

et al. 2017

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The guideline group was selected to be representative of UKbased medical experts with an interest in myeloproliferative neoplasms and eosinophilia. PubMed and EMBASE were searched systematically for publications in English until August 2015 using the key words eosinophilia, hypereosinophilia, eosinophilic leukaemia and HES. The writing group produced the draft guideline, which was subsequently revised by consensus by members of the General Haematology and Haematooncology Task Forces of the British Committee for Standards in Haematology (BCSH). The guideline was then reviewed by a sounding board of UK haematologists and representatives from the Nordic MPN Study Group, the BCSH and the British Society for Haematology (BSH) Committee, and comments were incorporated where appropriate. The 'GRADE' system was used to quote levels and grades of evidence, details of which can be found in Table I. The objective of this guideline is to provide healthcare professionals with clear guidance on the investigation and management of eosinophilia. Guideline updateThere is no previous BCSH guideline for this topic. AimThe purpose of this guideline is to provide a practical approach to the investigation and management of eosinophilia. Key recommendations• The underlying cause of eosinophilia should be sought and possible eosinophil-associated end-organ damage should be evaluated (Grade 1B). Assessment of underlying cause• A detailed medical history should be taken and a thorough physical examination should be performed (Grade 1C). The history should include:o assessment for allergic disorders, skin rashes and cardiorespiratory, gastrointestinal and constitutional symptoms.o a detailed travel history, particularly for tropical travel; travel even in the remote past may be relevant.o a detailed drug history.• All patients should have a full blood count, blood film examination and routine tests of renal and liver function, a bone profile, lactate dehydrogenase, erythrocyte sedimentation rate and/or C-reactive protein and vitamin B12 assay (Grade 1C) • Patients who are otherwise well with mild to moderate eosinophilia between 0Á5 and 1Á5 3 10 9

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Section: Secondary (Reactive) Eosinophiliamentioning

confidence: 99%

Guideline for the investigation and management of eosinophilia

et al. 2017

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“…Harvey et al reported PBE of 3% or more in 15 of 46 patients with SLE but only two patients had absolute eosinophil counts over 400/µL [93]. Reports of marked eosinophilia in association with SLE are restricted to single-case reports of SLE with concomitant Loeffler endocarditis [94,95], Wells’ syndrome [96], eosinophilic pleuritis [97], or EGPA and HES [98].…”

Section: Eosinophilia In Kidney Diseasementioning

confidence: 99%

Eosinophilia and Kidney Disease: More than Just an Incidental Finding?

Gauckler

Smıth

Mayer

et al. 2018

JCM

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Peripheral blood eosinophilia (PBE), defined as 500 eosinophils or above per microliter (µL) blood, is a condition that is not uncommon but often neglected in the management of patients with chronic kidney disease (CKD), acute kidney injury (AKI), or patients on renal replacement therapy (RRT). The nature of PBE in the context of kidney diseases is predominantly secondary or reactive and has to be distinguished from primary eosinophilic disorders. Nonetheless, the finding of persistent PBE can be a useful clue for the differential diagnosis of underdiagnosed entities and overlapping syndromes, such as eosinophilic granulomatosis with polyangiitis (EGPA), IgG4-related disease (IgG4-RD), acute interstitial nephritis (AIN), or the hypereosinophilic syndrome (HES). For patients on RRT, PBE may be an indicator for bio-incompatibility of the dialysis material, acute allograft rejection, or Strongyloides hyperinfection. In a subset of patients with EGPA, eosinophils might even be the driving force in disease pathogenesis. This improved understanding is already being used to facilitate novel therapeutic options. Mepolizumab has been licensed for the management of EGPA and is applied with the aim to abrogate the underlying immunologic process by blocking interleukin-5. The current article provides an overview of different renal pathologies that are associated with PBE. Further scientific effort is required to understand the exact role and function of eosinophils in these disorders which may pave the way to improved interdisciplinary management of such patients.

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“… 1 Interface dermatitis, lichenoid infiltration, basal cell vacuolation, and mucinous deposition are characteristics of the histopathology of LE‐specific lesions. 2 Pustular appearance is one of the least often documented presentations reported in the setting of amicrobial pustulosis of the folds (APF), 3 generalized pustular psoriasis, 4 acneiform eruptions, 5 pustular vasculitis, 6 Wells' syndrome, 7 subcorneal pustular dermatosis, 8 and neutrophilic dermatosis. 9 Here, we describe annular lesions with marginal pustules in a patient whose condition was subsequently identified as SLE.…”

Section: Introductionmentioning

confidence: 99%

Annular pustular crusted plaques as unusual cutaneous presentation of systemic lupus erythematosus

Gheisari

Baghani

Ganji

et al. 2023

Clinical Case Reports

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Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects several organs including the skin. Clinical cutaneous symptoms of SLE come in a broad range, consisting of both non-specific and specific cutaneous lesions. Except for cases of amicrobial pustulosis of the folds, generalized pustular psoriasis, acneiform eruptions, pustular vasculitis, Wells' syndrome, subcorneal pustular dermatosis, and neutrophilic dermatosis, there are no reports of pustular lesions linked to SLE. The unusual cutaneous features of our patient were annular plaques with pustules and crusts on the margins.

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Systemic lupus erythematosus associated with Wells’ syndrome

Cited by 7 publications

References 14 publications

Guideline for the investigation and management of eosinophilia

Guideline for the investigation and management of eosinophilia

Eosinophilia and Kidney Disease: More than Just an Incidental Finding?

Annular pustular crusted plaques as unusual cutaneous presentation of systemic lupus erythematosus

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