Systemic Lupus Erythematosus Complicated with Acute Myocardial Infarction and Ischemic Colitis

Matsumoto, Yoshinori; Wakabayashi, Hiroshi; Otsuka, Fumio; Inoue, Kentaro; Takano, Mariko; Sada, Ken‐ei; Makino, Hírofumi

doi:10.2169/internalmedicine.50.5966

Cited by 4 publications

(4 citation statements)

References 23 publications

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“…Phlebosclerotic colitis is a rare but increasingly recognized cause of IC related to venous obstruction [10]. Systemic lupus erythematosus can also be complicated by IC [11]. Thus, IC is both prevalent, and complicated by other also relatively common afflictions and diseases, which complicates its management.…”

Section: Identification Of People At Riskmentioning

confidence: 99%

Diagnostic methods and drug therapies in patients with ischemic colitis

Xiong

et al. 2020

Int J Colorectal Dis

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Purpose Ischemic colitis (IC) is the most prevalent ischemic injury of thegastrointestinal tract. Clinical features of IC such as acute abdominal pain, hematochezia,and diarrhea are similar to those of acute mesenteric ischemia, inflammatorybowel disease, or infectious bowel disease, and their relative ambiguity candelay diagnosis and treatment. To comprehensively detail the current state ofdiagnostic methods and available drug therapies for detecting and treating IC,this review aims to provide a concise and practical summary of thecorresponding literature. Methods PubMed and Cochrane Library were searched toretrieve all published studies reporting the diagnostic methods and drugtherapies in patients with ischemic colitis. The search strategy of drugtherapy includes human and animal data. Results Colonoscopy combined with histopathologicalbiopsy is the standard of diagnosis for the IC. Most patients respond well tothe conservative treatment, and surgical consultation is needed when conservativetreatment is ineffective. Studies of potential drug therapy have beendeveloped, including phosphodiesterase type 5 inhibitors, pentoxifylline,rebamipide, prostaglandin E1, and polydeoxyribonucleotide. Conclusion Accurate diagnoses and effective treatmentshave helped reduce the mortality rate and improve prognoses for patientsafflicted with IC, and corresponding drug therapies have been constantlyupdated as new research has emerged.

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Section: Identification Of People At Riskmentioning

confidence: 99%

Diagnostic methods and drug therapies in patients with ischemic colitis

Xiong

et al. 2020

Int J Colorectal Dis

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“…Patients who present with an acute surgical abdomen, as in the current case, represent a high morbidity and mortality risk for patients with SLE with mortality rates of 39% (14 of 36 cases) in patients with active SLE presenting with acute abdomens [1]. Unique to the current case was the extent of necrotic involvement necessitating a resection of the entire rectum to the anorectal junction [10]. Described a case of ischaemic transverse colonic perforation requiring an oversew and colostomy formation though the full extent of mucosal involvement of colonoscopy was diffuse throughout the colon [10].…”

Section: Discussionmentioning

confidence: 99%

“…Unique to the current case was the extent of necrotic involvement necessitating a resection of the entire rectum to the anorectal junction [10]. Described a case of ischaemic transverse colonic perforation requiring an oversew and colostomy formation though the full extent of mucosal involvement of colonoscopy was diffuse throughout the colon [10]. In the current case, we advocated for a more aggressive resection given the difficulty of accessing the area of necrotic perforation within the pelvis as well as the extent of necrotic involvement.…”

Section: Discussionmentioning

confidence: 99%

A rare case of lupus-related gastrointestinal vasculitis presenting as rectal gangrene

Liang

Khoury

2019

Journal of Surgical Case Reports

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Systemic lupus erythematosus (SLE) related gastrointestinal vasculitis is a rare condition limited to case studies within the literature however, no cases of rectal gangrene and perforation have been previously described. A 32-year-old male presented with abdominal pain, vomiting and fevers. CT demonstrated free gas and free fluid around the rectum indicative of a perforation. He proceeded to urgent laparotomy, confirming a diagnosis of rectal infarction and perforation. Uniquely, the involved segment of gangrene extended from the rectosigmoid to the anorectal junction. A Hartmanns procedure was performed. Histopathology confirmed underlying stenosis of the rectal arteries secondary to chronic vasculitis related to the affected areas. The current case is a unique presentation of SLE-related vasculitis. It highlights the need to judiciously investigate SLE patients presenting with surgical acute abdomen.

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“…in patients with SLE compared to the control [19,[22][23][24][25], while the CAD mortality rate ranges from 3.5 to 15.7% [26]. It should be noted that diagnostic imaging revealed subclinical atherosclerosis in 30-52% of SLE patients [24,25,27,28].…”

Section: Introductionmentioning

confidence: 94%

Accelerated Atherosclerosis in Patients with Systemic Lupus Erythematosus and the Role of Selected Adipocytokines in This Process

Hrycek¹,

Banasiewicz-Szkróbka²,

AleksanderŻurakowski³

et al. 2017

Lupus

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Systemic lupus erythematosus (SLE) can afect various systems and organs. The most severe forms of the disease afect the kidneys, the central nervous system, and the heart. Cardiac and cardiovascular system diseases are inter alia caused by atherosclerosis, vasculitis, and thromboembolic events. Patients with SLE are at a higher risk of developing accelerated atherosclerosis. This process in SLE patients cannot be explained solely based on classical risk factors. Recently, some adipocytokines/adipokines have been indicated in the development of atherosclerosis, inlammation, and immune processes. It has also been postulated that adipokines might regulate the immune response and hence the atherogenic process. In this work, the factors contributing to accelerated atherosclerosis in SLE patients with special respect to vasculitis/vascular injury are presented, and selected adipocytokines, that is leptin, resistin, and adiponectin, with their relation to atherosclerosis and SLE, are under discussion.

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Systemic Lupus Erythematosus Complicated with Acute Myocardial Infarction and Ischemic Colitis

Cited by 4 publications

References 23 publications

Diagnostic methods and drug therapies in patients with ischemic colitis

Diagnostic methods and drug therapies in patients with ischemic colitis

A rare case of lupus-related gastrointestinal vasculitis presenting as rectal gangrene

Accelerated Atherosclerosis in Patients with Systemic Lupus Erythematosus and the Role of Selected Adipocytokines in This Process

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