Systemic lupus erythematosus flare during SARS‐CoV‐2 infection: Report of 3 cases presented during the fourth wave of the pandemic in Colombia

Naranjo-Millán, Julián Alberto; Bedoya-Joaqui, Vanessa; Cañas, Carlos A.

doi:10.1111/1756-185x.14657

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…Isolated cases of SLE flares involving various organ systems such as the kidneys and the central nervous system have been reported during or following SARS-CoV-2 infection. [14][15][16][17][18][19] In a retrospective series of 51 Italian SLE patients, flares of SLE developed in 5.9% of patients after a diagnosis of COVID-19. 20 To our knowledge, only a handful of cases of de novo SLE, lupus nephritis or cutaneous lupus in otherwise healthy individuals after SARS-CoV-2 infection have ever been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

De novo lupus nephritis after SARS-CoV-2 infection

Mok

Chu

Tse

2023

Lupus

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The relationship between viral infection and onset of autoimmune diseases such as systemic lupus erythematosus remains uncertain. During the COVID-19 pandemic, organ-specific and multisystemic autoimmune phenomena temporally related to the viral infection have been described. Immune dysregulation triggered by the SARS-CoV-2 virus leading to hyperactivation of both the innate and adaptive immune systems contributes to the excessive production of pro-inflammatory cytokines, autoantibodies, and subsequent autoimmune manifestations. We report two patients without known autoimmune diseases who developed lupus nephritis shortly after a documented mild SARS-CoV-2 infection. Together with other similar cases in the literature, the observation supports a viral trigger of the development of systemic lupus erythematosus in susceptible individuals.

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Section: Introductionmentioning

confidence: 99%

De novo lupus nephritis after SARS-CoV-2 infection

Mok

Chu

Tse

2023

Lupus

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Effect of SARS-CoV2 infection on disease flares in patients with systemic lupus erythematosus: a case–control study

Mok,

Cheung,

Chan

et al. 2023

Rheumatology

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Objectives To study the effect of SARS-CoV2 infection on flares of systemic lupus erythematosus (SLE). Methods Patients who fulfilled the ACR/SLICC criteria for SLE and had documented COVID-19 between February and November 2022 were identified retrospectively from our hospital COVID-19 registry. SLE controls who did not have SARS-CoV2 infection were randomly matched for age, sex and the time of infection in a 2:1 ratio with those infected. The primary outcome of interest was clinical flare of SLE within 90 days of COVID-19. The rate of SLE flares (mild/moderate or severe) was compared between SARS-CoV2-infected SLE patients and controls. Results 91 SLE patients with COVID-19 (age 48.6 ± 14.0 years; 95.6% women) and 182 SLE controls (age 48.7 ± 13.8 years; 95.6% women) were studied. Eleven of 91 (12.1%) SARS-CoV2-infected patients had serious manifestations. One (1.1%) patient died and 7(7.7%) developed severe complications. Within 90 days of SARS-CoV2 infection, 14(15.4%) patients developed mild/moderate clinical SLE flares and 2(2.2%) patients had severe SLE flares. The incidence of SLE flares in SARS-CoV2-infected patients was significantly higher than those without the infection (17.6% vs 5.5%; odds ratio 3.67[1.59–8.46]; p = 0.001). The changes in anti-dsDNA and complement levels, however, were not significantly different between the two groups. Among SARS-CoV2-infected SLE patients, those with clinical SLE flares had significantly lower C3 values (p = 0.004) before the infection than those without. Conclusion Clinical flares within 90 days were significantly more common in SLE patients infected with SARS-CoV2 than matched non-infected SLE controls.

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Systemic lupus erythematosus flare during SARS‐CoV‐2 infection: Report of 3 cases presented during the fourth wave of the pandemic in Colombia

Cited by 2 publications

References 13 publications

De novo lupus nephritis after SARS-CoV-2 infection

De novo lupus nephritis after SARS-CoV-2 infection

Effect of SARS-CoV2 infection on disease flares in patients with systemic lupus erythematosus: a case–control study

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