Systemic Lupus Erythematosus in a Child With Sickle Cell Disease

Eissa, M M; Lawrence, Joseph Monday; McKenzie, Lorraine; Little, Felicia; Mankad, Vipul N.; Yang, Yih‐Ming

doi:10.1097/00007611-199511000-00023

Cited by 17 publications

(18 citation statements)

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“…Coexistence of SCD and SLE has been previously reported but, because of the limited number of cases from previous reports it is not possible to conclude whether SLE is more or less prevalent in patients with sickle cell hemoglobinopathies [1,[3][4][5]. In fact, a MEDLINE search of the literature, from 1970 to 2004 revealed only 19 cases of coexisting SLE and SCD, from which only 14 fulfilled the 1997 revised criteria of the ACR, which highlights the rarity of the overlap between these entities [1] and since both conditions have a high prevalence in blacks, a protective effect of SCD in preventing SLE has been speculated [1,7].…”

Section: Discussionmentioning

confidence: 99%

“…The classification of SLE is made when a patient fulfills at least four of the 11 revised criteria established by the American College of Rheumatology (ACR) in 1997. Fever, ar-Year 2012 Volume:1 Issue:1 71-76 thralgia/arthritis and myalgia are common in both conditions [3,4]. Additionally, both diseases commonly affect the renal, cardiovascular and central nervous systems [4].…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, both diseases commonly affect the renal, cardiovascular and central nervous systems [4]. Although the etiology of this two conditions is different, their coexistence has been rarely reported [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Parvovirus B19 Associated Systemic Lupus Erythematosus in a Child with Sickle Cell Disease; a Diagnostic and Therapeutic Challenge

Cabral¹,

Dias²,

Abadesso³

et al. 2012

Ann Paediatr Rheum

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Although sickle cell disease (SCD) and systemic lupus erythematosus (SLE) are two distinct and relatively common chronic diseases, coexistence of these two conditions in the same patient appears to be rare. The authors report an eight-year-old child with SCD who developed a severe form of parvovirus B19-associated SLE, with secondary severe immune hemolytic anemia related to drugs, Libman-Sacks endocarditis complicated by severe aortic regurgitation, dilated left ventricle with impaired function and myocardial ischemia, with further decompensation culminating in cardiac arrest during an infectious intercurrence, which led to death. This patient displayed a broad spectrum of musculoskeletal, hematologic and cardiovascular complications, which could be associated with either SCD or SLE. Because of a substantial overlap between the clinical manifestations of these two disorders, the diagnosis of SLE in a patient with a previously known diagnosis of SCD may be difficult and is often delayed. Our report illustrates the importance of considering other disease processes, like autoimmune diseases when clinical features or its evolution are atypical of SCD and emphasizes some of the diagnostic difficulties encountered during the diagnosis and management of these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Parvovirus B19 Associated Systemic Lupus Erythematosus in a Child with Sickle Cell Disease; a Diagnostic and Therapeutic Challenge

Cabral¹,

Dias²,

Abadesso³

et al. 2012

Ann Paediatr Rheum

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show abstract

“…5,6,[9][10][11][13][14][15][16][17][18][19][20][21][22] A dificuldade diagnóstica de se pensar na coexistência entre essas duas doenças deve-se ao fato de ambas cursarem com manifestaç ões articulares. Dessa forma, as queixas articulares do paciente com DF são interpretadas como crises vaso-oclusivas atrasando o diagnóstico do LES.…”

Section: Desordens Articularesunclassified

Coexistência de lúpus eritematoso sistêmico e doença falciforme: relato de caso e revisão da literatura

Robazzi

Alves

Abreu

et al. 2015

Revista Brasileira de Reumatologia

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“…This may suggest an etiopathological link between these two phenomena. Coexistence of SCD and SLE has been reported by several authors, and due to their overlapping clinical features, making the diagnosis of CTD in the presence of SCD is somewhat difficult [2,4,[9][10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Clinical and laboratory characteristics of patients with sickle-cell and autoimmune/connective tissue diseases

2010

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Patients with sickle-cell disease who develop autoimmune connective tissue disorders can present with similar clinical manifestations and/or complications making them indistinguishable. We report here a single-institution study on a cohort of 24 patients, with the above combination. The results suggest that there is often a significant delay in making the second diagnosis because of the overlapping clinical profile. It is emphasized that the clinician should be aware of and vigilant about such cases and should diligently follow up such cases to make an early diagnosis and start the appropriate treatment.

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Systemic Lupus Erythematosus in a Child With Sickle Cell Disease

Cited by 17 publications

References 0 publications

Parvovirus B19 Associated Systemic Lupus Erythematosus in a Child with Sickle Cell Disease; a Diagnostic and Therapeutic Challenge

Parvovirus B19 Associated Systemic Lupus Erythematosus in a Child with Sickle Cell Disease; a Diagnostic and Therapeutic Challenge

Coexistência de lúpus eritematoso sistêmico e doença falciforme: relato de caso e revisão da literatura

Clinical and laboratory characteristics of patients with sickle-cell and autoimmune/connective tissue diseases

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