Systemic Lupus Erythematosus in the Community

Wj, Fessel

doi:10.1001/archinte.1974.00320240061006

Cited by 339 publications

(33 citation statements)

References 17 publications

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“…The racial distribution in patients with olderonset SLE is even more interesting: only 20% of these patients were black, as compared with 59% of the younger patients, a highly significant difference (P < 0.001). The predisposition of black females for development of SLE was noted by Siegel et al (10,ll) in epidemiologic studies in New York City and Jefferson County, Alabama, and has been recently reemphasized by Fessel (12). It has not been widely appreciated, however, that this predominance is apparently largely restricted to younger patients, even though the data of Siegel et a1 (10) suggested that the propensity for SLE to occur in black females was more apparent in patients aged 15-44.…”

Section: Discussionmentioning

confidence: 91%

Clinical features of systemic lupus erythematosus

Ballou

Khan

Kushner

1982

Arthritis & Rheumatism

198

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We compared the frequency of clinical features of systemic lupus erythematosus (SLE) and determined survival in 113 patients with younger-onset lupus (age <55 at clinical diagnosis) and 25 patients with olderonset disease (age 155 at diagnosis). The most striking difference was in the racial distribution; 59% of the younger patients were black, compared with only 20% of the oldeponset patients (I' < 0.001). Major manifestations of lupus (including clinically evident renal disease, central nervous system involvement, cutaneous involvement, and hemocytopenia) occurred with similar frequency in both age groups. Antibodies to DNA were detectable equally often in both groups, but hypocomplementemia was more common in the younger patients. Five-year survival in the younger-onset group (79%) was similar to that of the older-onset group (72%); there was a tendency toward relatively improved survival in patients in the latter group when compared with the expected survival of appropriately matched control populations. Major significant differences in racial distribution included 1) a higher incidence of serositis in older whites and in blacks regardless of age, and 2 ) more frequent hypocomplementemia in younger patients ' within both racial groups.

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Section: Discussionmentioning

confidence: 91%

Clinical features of systemic lupus erythematosus

Ballou

Khan

Kushner

1982

Arthritis & Rheumatism

198

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“…SS is a common rheumatic disorder with a prevalence, compared with other rheumatic diseases, that has been estimated to be second only to RA (28), which affects between 1% (29) and 3% (30) of the world's population. Recent epidemiologic studies suggest that SS may be even more common than was thought previously (31,32), and thus is much more common than SLE (for which the reported prevalence is up to 0.05% [33,34]). Up to 25% of primary SS patients seen at our institution manifest nervous system disorders that are not attributable to other causes (2,4,6), and it is our growing impression that neuropsychiatric disease may be a common, previously unrecognized complication of this disease.…”

Section: Discussionmentioning

confidence: 99%

Peripheral inflammatory vascular disease in Sjögren's syndrome. Association with nervous system complications

Molina

Provost

Alexander

1985

Arthritis & Rheumatism

103

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Two histopathologic types of inflammatory vascular disease (IVD) occur in Sjogren's syndrome (SS):mononuclear IVD (MIVD) and neutrophilic IVD (NIVD). We describe 50 SS patients with IVD (30 with NIVD and 20 with MIVD). Thirty-three (66%) of the SS patients with biopsy-documented IVD had nervous system disease unattributable to other causes. Nineteen patients (58%) had involvement of both the central and peripheral nervous systems, while 9 had peripheral and 5 had central nervous system dysfunction alone. Patients with both histopathologic types of IVD were at risk for the development of nervous system abnormalities (57 % of NIVD patients and 80% of MIVD patients). Indirect evidence is presented which suggests that IVD may play a role in the immunopathogenesis of nervous system disease, at least in a subset of SS patients.

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“…The overall survival rates were similar to those observed in San Francisco. 2 An explanation for these differences in prevalence is lacking. In particular the evidence from HLA tissue typing studies has been unhelpful.…”

Section: Discussionmentioning

confidence: 99%

“…In the United States8 from 1968 to 1972 the rates for white and black females were 5 2 and 14*8 per million person years respectively. The overall rate for blacks was 2 The prevalence of SLE was estimated by counting all patients found and subtracting deaths occurring during the period. These figures were related to the population estimates derived from the 1976 National Census.…”

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confidence: 99%