Systemic Lupus Erythematosus, Osteoporosis, and Fractures

Adachi, Jonathan D.; Lau, Arthur

doi:10.3899/jrheum.140919

Cited by 12 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Systemic lupus erythematosus (SLE) is a common autoimmune disease, which is characterized by the abnormal activation of self-reactive T and B cells and production of self-antibodies and immune complex, and can lead to irreversible damage to organ systems [ 1 ]. Complications such as osteoporosis, urinary system diseases, and pseudo obstruction that resulted from SLE have brought huge damage for patients' life [ 2 , 3 ]. Even though several diagnostic criteria have been made for SLE diagnosis in clinical and played certain significant roles in SLE treatment and diagnosis, the results for SLE diagnosis still remain unsatisfactory due to the diversity and hidden characteristics, serology indexes, and complicate pathogen mechanism [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation between TLR9 Expression and Cytokine Secretion in the Clinical Diagnosis of Systemic Lupus Erythematosus

Rao

Zeng

Liang

et al. 2015

Mediators of Inflammation

View full text Add to dashboard Cite

To investigate the correlation between TLR9 and cytokine secretion in SLE diagnosis and treatment. A total of 66 cases (39 SLE and 27 healthy donors) were enrolled in this study. The CD20+ labeled B cells were isolated from SLE patients. TLR9 mRNA expression from SLE tissues and B cells was detected using RT-PCR. The cytokine secretion in B cells were measured using ELISA. Correlation between TLR9 expression and cytokines secretion was analyzed using gene silencing method. Compared with the controls, TLR9 expression was significantly high in SLE patients tissues, as well as in B cells. Expressions of IL-6 and ds-DNA antibody were high in SLE patients serum and were positively correlated with TLR9 level in SLE patients (IL-6, R 2 = 0.768; ds-DNA antibody, R 2 = 0.730). The IL-6 and ds-DNA expression were significantly decreased by silencing TLR9 compared to the controls. Moreover, silencing TLR9 significantly decreased cytokines secretion including IL-6, IL-10, and IL-1rα, as well as the pathway-associated protein expression, including ICOS and Foxp3. The successful application of TLR9 silencing method in human SLE B cells may loan theatrical basis for the possibility of TLR9 genetic therapy in SLE diagnosis and treatment.

show abstract

Section: Introductionmentioning

confidence: 99%

Correlation between TLR9 Expression and Cytokine Secretion in the Clinical Diagnosis of Systemic Lupus Erythematosus

Rao

Zeng

Liang

et al. 2015

Mediators of Inflammation

View full text Add to dashboard Cite

show abstract

“…Osteoporosis is an common complication of lupus, [28] and mandibular bone can reflect systemic osteoporotic alterations [29][30][31], which can be analyzed by radiomorphometric indexes, such as MCI in panoramic radiographs. Moreover, MCI has been already significantly inversely correlated with DEXA results in several studies [11,12,14].…”

Section: Discussionmentioning

confidence: 99%

Periodontal disease defects and mandibular cortical index in lupus patients

Braga¹,

Morita²,

Munhoz³

et al. 2019

BDS

View full text Add to dashboard Cite

Objective:Systemic lupus erythematosus is an autoimmune disease that affects multiple organs. It is well known that lupus patients have higher risk of osteoporosis, but if the disease affects mandibular cortical bone and alveolar bone is not fully established. The objective of this study was to evaluate periodontal disease defects and mandibular osteoporotic alterations in patients with lupus as compared to healthy patients using panoramic radiographs.Material and Methods:The panoramic radiographs of 72 patients with lupus and 360 healthy patients were evaluated for the presence of bone loss secondary to periodontal disease, classified as horizontal and vertical bone loss. We also assessed mandibular osteoporotic alterations by using the mandibular cortical index. Logistic regression analysis was applied to estimate the risk of mandibular osteoporotic alterations as well as horizontal and vertical bone loss in patients with lupus as compared to healthy patients.Results:There were no statistically significant differences between groups in the presence of horizontal bone defects and mandibular cortical indexes. However, patients with lupus demonstrated that patients with lupus were 2.17 more likely to present vertical bone loss than healthy patients.Conclusions:Patients with lupus might have higher risk of vertical bone loss than healthy patients due to pathophysiology of their disease. Further larger prospective studies should be performed to confirm our findings.

show abstract

“…Neben der allgemeinen entzündlichen Aktivität ist bei SLE die Steroidtherapie ein wichtiger Faktor. Patienten mit Nierenbeteiligung entwickeln zudem oft einen sekundären Hyperparathyreoidismus mit entsprechenden osteologischen Folgen [1,3,17,29,30].…”

Section: Lupus Erythematosusunclassified

Entzündlich-rheumatische Erkrankungen als Risikofaktoren für Osteoporose

Frey¹

2014

Gynäkologische Endokrinologie

View full text Add to dashboard Cite

Systemic Lupus Erythematosus, Osteoporosis, and Fractures

Cited by 12 publications

References 17 publications

Correlation between TLR9 Expression and Cytokine Secretion in the Clinical Diagnosis of Systemic Lupus Erythematosus

Correlation between TLR9 Expression and Cytokine Secretion in the Clinical Diagnosis of Systemic Lupus Erythematosus

Periodontal disease defects and mandibular cortical index in lupus patients

Entzündlich-rheumatische Erkrankungen als Risikofaktoren für Osteoporose

Contact Info

Product

Resources

About