Systemic Lupus Erythematosus Presenting as Acute Posterior Multifocal Placoid Pigment Epitheliopathy - Case Report and Review of the Ocular Manifestations of Systemic Lupus Erythematosus

Chan, Si-Wa; Gottlieb, Chloe

doi:10.23937/2378-346x/1410038

Cited by 4 publications

(2 citation statements)

References 163 publications

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“…Generally characterized by serous detachments of the retina with or without detachment of the retinal pigment epithelium, choroidopathy may not be visually significant unless the macula is involved. Choroidopathy can also manifest as acute posterior multifocal placoid pigment epitheliopathy [46]. Like lupus retinopathy, immune complex deposition is thought to be involved [39], leading to inflammatory cell infiltration, vascular leakage, and subsequent choroidal thickening [47,48].…”

Section: Choroidmentioning

confidence: 99%

Update on ophthalmic manifestations of systemic lupus erythematosus: pathogenesis and precision medicine

Lee

Zickuhr

Hassman

2021

Current Opinion in Ophthalmology

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Purpose of reviewSystemic lupus erythematosus (SLE) is an autoimmune disease with manifestations in multiple organs including the eyes. Several ocular manifestations like dry eye, retinopathy, and choroidopathy have been linked with specific systemic manifestations like lupus nephritis or CNS disease. Furthermore, the presence of ocular manifesattions can correlated with the severity of SLE. Finally, some medications used in the treatment of uveitis can present with lupus-like disease. Therefore, communication between the ophthalmologist and rheumatologist is vital. Recent findingsOcular and systemic manifestations of SLE can be linked by common pathological processes including immune complex deposition, complement fixation, and vascular injury. Recent research correlating ophthalmic imaging with SLE disease has yielded heterogeneous results likely due to the clinical heterogeneity of SLE, but molecular technologies have and will continue to yield contributions to the emergence of new therapeutics for the treatment of SLE.

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Section: Choroidmentioning

confidence: 99%

Update on ophthalmic manifestations of systemic lupus erythematosus: pathogenesis and precision medicine

Lee

Zickuhr

Hassman

2021

Current Opinion in Ophthalmology

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“…Those patients may receive an adjunctive ocular treatment to preserve vision, such as plasmapheresis, focal laser and photodynamic therapy (PDT), and surgery. 40 Focal laser photocoagulation and PDT have been used in abnormal choroidal hyperpermeability or neovascularization. These procedures are successful treatment options, resolving subretinal fluid secondary to lupus choroidopathy.…”

Section: Clinical Manifestations and Diagnosismentioning

confidence: 99%

Neuro-ophthalmologic manifestations in systemic lupus erythematosus

Andrade

Balbi

Azevedo

et al. 2017

Lupus

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect different ocular structures, such as cornea, conjunctiva, episclera, sclera, uveal tract, retina, optic nerve and vessels. Neuro-ophthalmologic manifestations in SLE include different degrees of involvement of retina, choroid and optic nerve. Retinal changes are one of the most common ocular involvements and are frequently used as clinical criteria for activity, even if isolated. Studies show that up to 29% of patients with active SLE manifest retinal disease. The exact prevalence of choroidal disease is unknown, but is thought to be less common than retinopathy, due to under-diagnosis. Optic nerve disease, represented by optic neuritis and anterior/posterior ischaemic optic neuropathy, affects approximately 1% of SLE patients. These ocular manifestations have been associated with neurologic flares, antiphospholipid antibodies, nephropathy, and increased mortality. The aim of this paper is to review the different aspects of neuro-ophthalmologic involvement in SLE. Since these manifestations are frequent and potentially severe, a multi-professional team approach is needed to investigate properly and provide early aggressive treatment in order to avoid visual sequelae.

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A case of choroidal neovascularization as a first manifestaion of systemic lupus erythematosus

Jalkh,

Abi Doumit,

Schakal

et al. 2024

Int Ophthalmol

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Systemic Lupus Erythematosus Presenting as Acute Posterior Multifocal Placoid Pigment Epitheliopathy - Case Report and Review of the Ocular Manifestations of Systemic Lupus Erythematosus

Cited by 4 publications

References 163 publications

Update on ophthalmic manifestations of systemic lupus erythematosus: pathogenesis and precision medicine

Update on ophthalmic manifestations of systemic lupus erythematosus: pathogenesis and precision medicine

Neuro-ophthalmologic manifestations in systemic lupus erythematosus

A case of choroidal neovascularization as a first manifestaion of systemic lupus erythematosus

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