Systemic lupus erythematosus presenting with atypical hemolytic uremic syndrome: a case report and review of the literature

Smith, Justin; Hans, Varinder; Yacyshyn, Elaine; Rouhi, Azin; Oliver, Monika

doi:10.1007/s00296-024-05558-9

Rheumatol Int

2024

DOI: 10.1007/s00296-024-05558-9

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Systemic lupus erythematosus presenting with atypical hemolytic uremic syndrome: a case report and review of the literature

Justin Smith,

Varinder Hans,

Elaine Yacyshyn

et al.

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Cited by 2 publications

References 47 publications

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2024

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Vascular injury in glomerulopathies: the role of the endothelium

Barbosa,

Câmara,

Ledesma

et al. 2024

Front. Nephrol.

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In glomerulopathies, endothelial dysfunction and the presence of histological vascular lesions such as thrombotic microangiopathy, arteriolar hyalinosis, and arteriosclerosis are related to a severe clinical course and worse renal prognosis. The endothelial cell, which naturally has anti-inflammatory and anti-thrombotic regulatory mechanisms, is particularly susceptible to damage caused by various etiologies and can become dysfunctional due to direct/indirect injury or a deficiency of protective factors. In addition, endothelial regulation and protection involve participation of the complement system, factors related to angiogenesis, the renin–angiotensin system (RAS), endothelin, the glycocalyx, the coagulation cascade, interaction between these pathways, interactions between glomerular structures (the endothelium, mesangium, podocyte, and basement membrane) and interstitial structures (tubules, arterioles and small vessels). Dysregulation of those components is also associated with the progression of renal fibrosis, since endothelial cell damage promotes endothelial-to-mesenchymal transition. Although the potential mechanisms of vascular injury have been widely described in diabetic kidney disease, hypertensive nephrosclerosis, and hemolytic uremic syndrome, they require further elucidation in other glomerulopathies. A better understanding of the pathogenesis of vascular injury in patients with glomerular diseases could contribute to the development of specific treatments for such injury.

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Systemic lupus erythematosus presenting with atypical hemolytic uremic syndrome: a case report and review of the literature

Cited by 2 publications

References 47 publications

Multiple drugs

Multiple drugs

Vascular injury in glomerulopathies: the role of the endothelium

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